A Structural View of Biology
This resource is powered by the Protein Data Bank archive-information about the 3D shapes of proteins, nucleic acids, and complex assemblies that helps students and researchers understand all aspects of biomedicine and agriculture, from protein synthesis to health and disease.
The RCSB PDB builds upon the data by creating tools and resources for research and education in molecular biology, structural biology, computational biology, and beyond.
Deposition Preparation Tools
- pdb_extract: Extract and harvest data in PDBx/mmCIF format from structure determination programs
- SF-Tool: Convert structure factor files among various formats
- Ligand Expo: Search the Chemical Component Dictionary for the IDs of released ligands
Data Format Conversion
Validation reports contain an assessment of the quality of a structure and highlight specific concerns by considering the coordinates of the model, the experimental data and the fit between the two. Easily interpretable summary information that compares the quality of a model with that of other models in the archive will help users of PDB data to critically assess archived entries and to select the most appropriate structural models for their needs. These reports are developed using the recommendations of thewwPDB Validation Task Forces.
Reports for released entries are available from Structure Summary pages.
Validation reports for manuscript reviewers are created during annotation of deposited structures.
Information and example Validation Reports (at wwpdb.org).
Check your X-ray, NMR, or EM structures before depositing (standalone server).
Have non-atomic coordinates, multi-scale structures obtained through integrative/hybrid (I/H) methods? Deposit at PDB-Dev which is a prototype deposition and archiving system for structural models obtained through integrative/hybrid (I/H) methods.
Questions about your deposition?
From any page on the site, a Basic Search can be run by entering a search term in the top Search Bar.
As you enter a term, you will see suggestions appearing in the dropdown menu that appears below the search bar. The suggestions are grouped by attribute name, indicating in the specific field or fields in which the search term was found.You can click on an item in the dropdown menu to see results matching only that particular attribute, or click the
The Advanced Search Query Builder tool allows you to construct complex boolean queries by specifying values for a wide range of structure attributes.
Text-based queries can be combined with sequence and structure similarity searches.
Search results can be returned at the structure, entity, or assembly level, and viewed in a variety of formats, for example, as a summary view, an images only gallery view, or in a Tabular Report format.
Any query and its results can be further refined by selecting additional criteria from the 'Refinements' panel.
Search by Sequences
Search protein and nucleic acid sequences using the mmseqs2 method to find similar protein or nucleic acid chains in the PDB.
The new Advanced Search Query Builder tool can be used to run sequence searches, and to combine the results with the other search criteria that are available.
Search by Unreleased & Access New Entries
The PDB archive is updated weekly in two phases
Phase I: Every Saturday by 3:00 UTC, for every new entry, wwPDB website provides sequence(s) (amino acid or nucleotide) for each distinct polymer and, where appropriate, the InChI string(s) for each distinct ligand and the crystallization pH value(s).
Phase II: Every Wednesday by 00:00 UTC, all new and modified data entries will be updated at each of the wwPDB FTP sites.
Next data entry update in:
Browse by Annotation
PDB entries have been annotated by various ontologies and hierarchical classification schemes.
- Anatomical Therapeutic Chemical Classification System
- Biological Process
- Cellular Component
- Enzyme Classification
- Genome Location
- Membrane Protein
- MeSH (Medical Subject Headings)
- Molecular Function
- Protein Symmetry
- Source Organism
Explore the PDB Archive
Search ligands bound to macromolecules in the PDB by:
- SMILES String, InChI
- Chemical Formula
Search by Drugs & Drug Targets
Drugs & Drug Targets in the PDB have been mapped to DrugBank. They have been made available through the integrated search system. You can find some search examples under the help examples page.
Drug-Target Complex: Atorvastatin bound to its target HMG-CoA reductase
Drug: Atorvastatin (Lipitor)
3D Structure Viewers
View PDB structures in 3D using Mol* from any entry's Structure Summary page.A 3D View (Mol*) User Guide is available.
RCSB Protein Feature View
Provides a graphical summary of biological and structural protein features of PDB entities and how they correspond to UniProtKB  sequences. It loads features from RCSB PDB webservices and third party resources such as UniProtKB, CATH or SCOPe.
Learn more about RCSB Protein Feature View.
This feature is available in Structure Summary pages and Instance Sequence pages.
Genome ViewIllustrates the correspondences between PDB Entity sequences and genomes. When the relationships between PDB Entities and genes are available, PDB Entity sequences are mapped to their genome positions to show which regions of a gene are available in the Entity coordinates.
Learn more about Genome View.
This feature is available from the Structure Summary page Genome tab.
Pairwise Structure Alignment
The standalone Mol* viewer application allows for calculating pairwise structure alignments.
Comparisons can be made for any protein in the PDB archive and for customized or local files not in the PDB.
See detailed instructions on how to superpose structures at the Mol* help page.
The Mol* symmetry display mode (select the Assembly Symmetry button) highlights global, local, and helical symmetry among subunits. The view displays the symmetry axes, a polyhedron that reflects the symmetry, and a color scheme that emphasizes the symmetry.
Structure Summary pages provide access to information about structure quality.
The slider graphic compares important global quality indicators for a given structure with the PDB archive. Global percentile ranks (black vertical boxes) are calculated with respect to all X-ray structures available prior to 2011. Resolution-specific percentile ranks (white vertical boxes) are calculated considering entries with similar resolution.
This graphic is from the wwPDB Validation Report , which provides a more detailed assessment of the quality of a structure and highlights specific concerns. These reports were created using the recommendations of wwPDB Validation Task Forces.The full wwPDB Validation Report PDF is available for download. PDFs of Ramachandran plots (created by MolProbity) are provided to offer an independent method to evaluate the conformational quality of protein structures.
Map Genomic Locations to/from PDB
The 1D-coordinates API provides means to map between genomic coordinates and PDB positions. Find more information about this and other APIs in the webservices page.1D-coordinates API tutorial
EPPIC Biological Assemblies
EPPIC (Evolutionary Protein-Protein Interface Classifier) provides value-added information about biological assemblies in the PDB. This web server classifies interfaces present in protein crystals to distinguish biological interfaces from crystal contacts. EPPIC Version 3 enumerates all possible symmetric assemblies with a prediction of the most likely assembly based on probabilistic scores from pairwise evolutionary scoring.
Download Coordinate & Experimental Data Files
By entering PDB IDs, multiple files can be downloaded in batches containg one or more file formats.
Coordinate Data Files can be downloaded in the following formats:
- PDBML/XML (Header only)
- Biological Assemblies in PDB
- Biological Assemblies in PDBx/mmCIF
Experimental Data Files can be downloaded in the following formats:
- Structure Factors
- NMR Restraints
- Chemical Shifts
- NMR Restraints v2
By entering PDB IDs, sequences can be downloaded in FASTA format.
Sequences can be provided for any of these identifiers:
- Entry IDs
- Entity IDs
- Asym IDs
By entering chemical component IDs, SDF files with ligand coordinates can be downloaded.
Downloads are provided for:
- Coordinates of first chemical component instance from each PDB entry
- Coordinates of all chemical component instances from each PDB entry
- Ideal coordinates from Chemical Component Dictionary
Searches and reports performed on this RCSB PDB website utilize data from the PDB archive. The PDB archive is maintained by the wwPDB at at FTP archive, ftp.wwpdb.org (data download details) and Versioned FTP, ftp-versioned.wwpdb.org (Versioning details).
- The directory pub/pdb is the entry directory for the ftp site.
- The directory pub/pdb/data/structures/divided contains the current PDB contents including PDB, mmCIF, and PDBML/XML formatted coordinate files, structure factors and NMR restraints
Annual snapshots of PDB Archive are available. Read More on FTP Services
PDB structure files, chemical component files, and several other files are available for download via http/https. These URLs are useful in scripted downloads using utilities such as wget.
- PDB Structure Files
- Ligand Files
- Secondary Structure Files
- SIFTS Files
Programmatic access to individual structures and/or specific data items is provided through Web Service Application Program Interfaces (APIs).
New Web Service APIs are being developed; users should register with the RCSB PDB API electronic list for announcements.
Contact RCSB PDB with questions suggestions for specific services.More
De novo TIM barrel-ferredoxin fold fusion homodimer with 4-glutamate centre TFD-EE
Cryo-EM structure of a chromatosome containing human linker histone H1.4
Crystal structure of the RLIP76 Ral binding domain mutant (E427S/L429M/Q433L/K440R) in complex with RalB-GMPPNP
Crystal structure of Echistatin, an RGD-containing short disintegrin
Cryo-EM structure of a chromatosome containing chimeric linker histone gH1.10-ncH1.4
Cryo-EM structure of the nonameric EscV cytosolic domain from the type III secretion system
Crystal structure of JAK2 with Compound 11
Influenza C virus polymerase in complex with human ANP32A - Subclass 1
Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H3 Hemagglutinin
Influenza C virus polymerase in complex with chicken ANP32A - Subclass 1
Features & Highlights
Explore Improved Carbohydrate Data
Search, visualize, and analyze carbohydrates in the PDB with new tools and features
Building Advanced Searches
Attribute options are now searchable to help users build a query.
Sequence Alignments in Search Results
For Sequence Similarity searches, display search results as "Polymer Entities" to view amino acid mismatches.
Build Customize Tabular Reports of PDB Data
After searching for a set of structures, create a table of information by selecting the columns of your choice. Tables can be saved in CSV or JSON formats.
Documentation for New and Improved APIs
Learn the concepts and syntax behind these new services. Legacy APIs will be discontinued November 2020
Search by Chemical Formula or Descriptor
Use Advanced Search>Chemical Search for small-molecule searching by formulae or descriptors (SMILES, InChI)
Updated Validation Reports for Released PDB Structures
Reports now include recalculated percentiles, 2D diagrams highlighting ligand quality, map and model fit for EM entries, and calculated map coefficients used for X-ray data validation.
Announcement: Legacy MyPDB Will Be Discontinued October 2020
Users should migrate to the new and improved version that uses third-party authentication
Explore Sequence-Structure Relationships
Protein Feature View maps PDB structures and corresponding UniProtKB sequences and other annotations in an updated interface
Real Time Structural Search of the PDB
A new paper describes a novel method that detects similarity between protein shapes and that works equally fast for any size of proteins or assemblies
See new feature archive
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Celebrate Geis' birthday (October 18, 1908) with a tour of the Tour the Geis Digital Archive developed in collaboration with HHMI. » 10/18/2020
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Molecule of the Month
Quarterly News (see archive)
New publications; updated validation reports; exploring sequence-structure relationships; from Boot Camp to Poster Prize; and more. Fall 2020 Issue