4HHB

THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION

Domain Annotation: SCOP Classification SCOP Database (version: 2.0) Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species
A	d4hhba_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	Human (Homo sapiens ) [TaxId: 9606 ]
C	d4hhbc_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	Human (Homo sapiens ) [TaxId: 9606 ]
B	d4hhbb_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	Human (Homo sapiens ) [TaxId: 9606 ]
D	d4hhbd_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	Human (Homo sapiens ) [TaxId: 9606 ]

Domain Annotation: CATH CATH Database (version 4.2.0) Homepage

Chain	Domain	Class	Architecture	Topology	Homology
A	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins
C	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins
B	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins
D	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A, C	PF00042	Globin (Globin)	Globin	-	Domain
B, D	PF00042	Globin (Globin)	Globin	-	Domain

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Hemoglobin subunit alpha	binding heme binding tetrapyrrole binding organic cyclic compound binding heterocyclic compound binding iron ion binding ion binding cation binding metal ion binding transition metal ion binding small molecule binding organic acid binding oxygen binding transporter activity oxygen carrier activity	response to toxic substance cellular process response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to toxic substance detoxification cellular oxidant detoxification cellular detoxification metabolic process catabolic process hydrogen peroxide metabolic process hydrogen peroxide catabolic process cellular metabolic process cellular catabolic process reactive oxygen species metabolic process cell death regulation of cell death positive regulation of cell death positive regulation of biological process positive regulation of cellular process regulation of biological process regulation of cellular process biological regulation	extracellular region extracellular space blood microparticle cellular anatomical entity intracellular cytoplasm cytosol ribosome small ribosomal subunit cytosolic ribosome cytosolic small ribosomal subunit protein-containing complex organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle ribosomal subunit ribonucleoprotein complex endocytic vesicle cytoplasmic vesicle membrane-enclosed lumen vesicle membrane-bounded organelle organelle lumen intracellular organelle lumen endocytic vesicle lumen intracellular vesicle extracellular organelle extracellular exosome extracellular vesicle haptoglobin-hemoglobin complex hemoglobin complex membrane
B, D	Hemoglobin subunit beta	binding heme binding tetrapyrrole binding organic cyclic compound binding heterocyclic compound binding protein binding hemoglobin binding hemoglobin alpha binding ion binding cation binding metal ion binding small molecule binding organic acid binding oxygen binding transporter activity oxygen carrier activity	response to toxic substance cellular process response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to toxic substance detoxification cellular oxidant detoxification cellular detoxification metabolic process catabolic process hydrogen peroxide metabolic process hydrogen peroxide catabolic process cellular metabolic process cellular catabolic process reactive oxygen species metabolic process cell death regulation of cell death positive regulation of cell death positive regulation of biological process positive regulation of cellular process regulation of biological process regulation of cellular process biological regulation	extracellular region extracellular space blood microparticle cellular anatomical entity intracellular cytoplasm cytosol endocytic vesicle cytoplasmic vesicle membrane-enclosed lumen vesicle organelle membrane-bounded organelle intracellular organelle organelle lumen intracellular organelle lumen endocytic vesicle lumen intracellular vesicle extracellular organelle extracellular exosome extracellular vesicle endomembrane system secretory granule secretory vesicle ficolin-1-rich granule ficolin-1-rich granule lumen haptoglobin-hemoglobin complex protein-containing complex hemoglobin complex tertiary granule tertiary granule lumen

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.