5LKX

Crystal structure of the p300 acetyltransferase catalytic core with propionyl-coenzyme A.


ChainDomainClassArchitectureTopologyHomology
A1.20.920.10 Mainly Alpha Up-down Bundle Histone Acetyltransferase Chain A
A2.10.110.40 Mainly Beta Ribbon Cysteine Rich Protein CREB-binding protein/p300 RING domain
A3.30.40.10 Alpha Beta 2-Layer Sandwich Herpes Virus-1 Zinc/RING finger domain, C3HC4 (zinc finger)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionIdentifierDescriptionCommentsSource
APF00569Zinc finger, ZZ type (ZZ)Zinc finger, ZZ typeZinc finger present in dystrophin, CBP/p300. ZZ in dystrophin binds calmodulin. Putative zinc finger; binding not yet shown. Four to six cysteine residues in its sequence are responsible for coordinating zinc ions, to reinforce the structure [2].Domain
APF08214Histone acetylation protein (HAT_KAT11)Histone acetylation proteinHistone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation. Loss of KAT11 ...Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation. Loss of KAT11 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin [1]. KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast [1]. This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11 [3].
Domain
APF00439Bromodomain (Bromodomain)BromodomainBromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].Domain
APF02172KIX domain (KIX)KIX domainCBP and P300 bind to the CREB via a domain known as KIX [1]. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.Domain
APF06001Domain of Unknown Function (DUF902) (DUF902)Domain of Unknown Function (DUF902)This domain of unknown function is found in several transcriptional co-activators including the CREB-binding protein, which is an acetyltransferase that acetylates histones, giving a specific tag for transcriptional activation. This short domain is f ...This domain of unknown function is found in several transcriptional co-activators including the CREB-binding protein, which is an acetyltransferase that acetylates histones, giving a specific tag for transcriptional activation. This short domain is found to the C-terminus of bromodomains. The 40 residue domain contains four conserved cysteines suggesting that it may be stabilised by a zinc ion. In CREB this domain is to the N-terminus of another zinc binding PHD domain.
Domain
APF09030Creb binding (Creb_binding)Creb bindingThe Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and ...The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery [1].
Domain
APF02135TAZ zinc finger (zf-TAZ)TAZ zinc finger- Family

Gene Product Annotation Gene Product Annotation

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
AHistone acetyltransferase p300,Histone acetyltransferase p300