6I5F

Crystal structure of DNA-free E.coli MutS P839E dimer mutant


Domain Annotation: SCOP Classification SCOP Database (version: 2.0) Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpecies
Ad6i5fa1 Alpha and beta proteins (a+b) MutS N-terminal domain-like DNA repair protein MutS, domain I automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
Ad6i5fa2 Alpha and beta proteins (a/b) Ribonuclease H-like motif DNA repair protein MutS, domain II automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
Ad6i5fa3 All alpha proteins DNA repair protein MutS, domain III DNA repair protein MutS, domain III automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
Ad6i5fa4 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
Bd6i5fb1 Alpha and beta proteins (a+b) MutS N-terminal domain-like DNA repair protein MutS, domain I automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
Bd6i5fb2 Alpha and beta proteins (a/b) Ribonuclease H-like motif DNA repair protein MutS, domain II automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
Bd6i5fb3 All alpha proteins DNA repair protein MutS, domain III DNA repair protein MutS, domain III automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
Bd6i5fb4 Alpha and beta proteins (a/b) P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases automated matches automated matches (Escherichia coli ) [TaxId: 562 ]
ChainDomainClassArchitectureTopologyHomology
A3.40.1170.10 Alpha Beta 3-Layer(aba) Sandwich MutS, DNA mismatch repair protein, domain I DNA repair protein MutS, domain I
A3.30.420.110 Alpha Beta 2-Layer Sandwich Nucleotidyltransferase domain 5
A1.10.1420.10 Mainly Alpha Orthogonal Bundle MutS, DNA mismatch repair protein Chain A, domain 3
A1.10.1420.10 Mainly Alpha Orthogonal Bundle MutS, DNA mismatch repair protein Chain A, domain 3
A1.10.1420.10 Mainly Alpha Orthogonal Bundle MutS, DNA mismatch repair protein Chain A, domain 3
A3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases
B3.40.1170.10 Alpha Beta 3-Layer(aba) Sandwich MutS, DNA mismatch repair protein, domain I DNA repair protein MutS, domain I
B3.30.420.110 Alpha Beta 2-Layer Sandwich Nucleotidyltransferase domain 5
B1.10.1420.10 Mainly Alpha Orthogonal Bundle MutS, DNA mismatch repair protein Chain A, domain 3
B1.10.1420.10 Mainly Alpha Orthogonal Bundle MutS, DNA mismatch repair protein Chain A, domain 3
B1.10.1420.10 Mainly Alpha Orthogonal Bundle MutS, DNA mismatch repair protein Chain A, domain 3
B3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases

Protein Family Annotation Pfam Database Homepage

ChainsAccessionIdentifierDescriptionCommentsSource
A, BPF01624MutS domain I (MutS_I)MutS domain IThis domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].
Domain
A, BPF05188MutS domain II (MutS_II)MutS domain IIThis domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. This domain corresponds to domain II in Thermus aquaticus MutS as characterised in [4], and has similarity resembles RNAse-H-like domains (see Pfam:PF00075).
Domain
A, BPF05192MutS domain III (MutS_III)MutS domain IIIThis domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterised in [4].
Domain
A, BPF00488MutS domain V (MutS_V)MutS domain VThis domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS prot ...This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterised in [4], which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.
Domain
A, BPF05190MutS family domain IV (MutS_IV)MutS family domain IVThis domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS prot ...This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds in part with globular domain IV, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].
Domain