6ORQ

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A, C, F	PF00516	Envelope glycoprotein GP120 (GP120)	Envelope glycoprotein GP120	-	Family
A, C, F	PF00517	Retroviral envelope protein (GP41)	Retroviral envelope protein	-	Family
B, G, I	PF00516	Envelope glycoprotein GP120 (GP120)	Envelope glycoprotein GP120	-	Family
B, G, I	PF00517	Retroviral envelope protein (GP41)	Retroviral envelope protein	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, F	RC1 variant of HIV-1 Env glycoprotein gp41	binding protein binding identical protein binding structural molecule activity	cellular process viral process cellular component organization viral life cycle fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiotic process entry into host interspecies interaction between organisms multi-organism cellular process multi-organism membrane fusion multi-organism membrane organization viral entry into host cell interaction with host multi-organism process movement in host environment membrane organization membrane fusion cellular component organization or biogenesis fusion of virus membrane with host plasma membrane response to external stimulus response to biotic stimulus modulation by virus of host process mitigation of host defenses by virus mitigation of host defenses by symbiont mitigation of host immune response by virus modulation of process of other organism response to external biotic stimulus modulation by symbiont of host process regulation of defense response to virus by virus response to stimulus response to other organism modulation of process of other organism involved in symbiotic interaction response to defenses of other organism response to host defenses response to host viral gene expression viral protein processing virion attachment to host cell biological adhesion adhesion of symbiont to host adhesion of symbiont to host cell	host cellular component host cell cytoplasm host cell part host cell membrane host intracellular part host intracellular organelle host intracellular membrane-bounded organelle host cell cytoplasm part host intracellular region host cell host cell endosome host cell endosome membrane cellular anatomical entity host cell plasma membrane membrane integral component of membrane intrinsic component of membrane virion viral envelope viral membrane virion part virion membrane
B, G, I	RC1 variant of HIV-1 Env glycoprotein gp120	binding protein binding identical protein binding structural molecule activity	cellular process viral process cellular component organization viral life cycle fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiotic process entry into host interspecies interaction between organisms multi-organism cellular process multi-organism membrane fusion multi-organism membrane organization viral entry into host cell interaction with host multi-organism process movement in host environment membrane organization membrane fusion cellular component organization or biogenesis fusion of virus membrane with host plasma membrane response to external stimulus response to biotic stimulus modulation by virus of host process mitigation of host defenses by virus mitigation of host defenses by symbiont mitigation of host immune response by virus modulation of process of other organism response to external biotic stimulus modulation by symbiont of host process regulation of defense response to virus by virus response to stimulus response to other organism modulation of process of other organism involved in symbiotic interaction response to defenses of other organism response to host defenses response to host viral gene expression viral protein processing virion attachment to host cell biological adhesion adhesion of symbiont to host adhesion of symbiont to host cell	host cellular component host cell cytoplasm host cell part host cell membrane host intracellular part host intracellular organelle host intracellular membrane-bounded organelle host cell cytoplasm part host intracellular region host cell host cell endosome host cell endosome membrane cellular anatomical entity host cell plasma membrane membrane integral component of membrane intrinsic component of membrane virion viral envelope viral membrane virion part virion membrane
D, H, J	Ab275MUR antibody Fab heavy chain	none	none	none
E, K, L	Ab275MUR antibody Fab light chain	none	none	none

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.