Chemical Component Summary

NamePHYLLOQUINONE
Identifiers2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
FormulaC31 H46 O2
Molecular Weight450.70
TypeNON-POLYMER
Isomeric SMILESCC(C)CCC[C@@H](C)CCC[C@@H](C)CCCC(/C)=C/CC1=C(C)C(=O)c2ccccc2C1=O
InChIInChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
InChIKeyMBWXNTAXLNYFJB-NKFFZRIASA-N

Chemical Details

Formal Charge0
Atom Count79
Chiral Atom Count2
Bond Count80
Aromatic Bond Count6

Drug Info: DrugBank

DrugBank IDDB01022 
NamePhylloquinone
Groups
  • approved
  • investigational
DescriptionPhylloquinone is often called vitamin K1. Phylloquinone is fat soluble and stable in air and moisture. However, it degrades in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.
Synonyms
  • Phyllochinonum
  • Phytomenadione
  • 2-Methyl-3-phytyl-1,4-naphthochinon
  • Phytonadione
  • Fitomenadiona
Brand Names
  • M.V.I. Adult
  • Pediatric Infuvite Multiple Vitamins for Infusion
  • Mephyton
  • Pro Pcos Citrus
  • Phytonadione Inj 2mg/ml
IndicationFor the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia.
Categories
  • Blood and Blood Forming Organs
  • Coagulants
  • Diet, Food, and Nutrition
  • Diterpenes
  • Drugs that are Mainly Renally Excreted
ATC-CodeB02BA01
CAS number84-80-0

Drug Targets

NameTarget SequencePharmacological ActionActions
Vitamin K-dependent gamma-carboxylaseMAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRR...unknowninducer
OsteocalcinMRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPR...unknownagonist
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682