Germinal-center associated nuclear protein - O60318 (GANP_HUMAN)


Protein Feature View of PDB entries mapped to a UniProtKB sequence  

As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). UniProt
Catalytic Activity
acetyl-CoA + L-lysyl-[histone] = CoA + H+ + N6-acetyl-L-lysyl-[histone] UniProt
Pathway Maps
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Subunit Structure
Isoform GANP: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY (PubMed:23591820, PubMed:22307388). Interacts with RNA polymerase II subunit POLR2A and with the transcription elongation factor SUPT5H/SPT5 (PubMed:23652018, PubMed:22307388). Interacts (via FG-repeats) with NXF1; this interaction is not mediated by RNA (PubMed:20005110). Isoform GANP interacts with nuclear envelope proteins NUP62, NUP153 and RANBP2/NUP358; interaction with NUP153 is required for full localization at the nuclear pore complex (PubMed:20005110, PubMed:23652018). Interacts with several RNA helicases, including DHX9, DDX21, and DDX39A/DDX39, and with DNA topoisomerase TOP2A (PubMed:23652018). Directly interacts with AICDA/AID (PubMed:20507984). Interacts with the glucocorticoid receptor NR3C1 (PubMed:16914116). Isoform MCM3AP: Interacts with the glucocorticoid receptor NR3C1 (PubMed:16914116). Interacts with MCM3; this interaction leads to MCM3 acetylation (PubMed:9712829, PubMed:11258703, PubMed:12226073). UniProt
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