Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic - P25858 (G3PC1_ARATH)


Protein Feature View of PDB entries mapped to a UniProtKB sequence  

Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility (PubMed:18820081). Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants (PubMed:22589465). Associates with FBA6 to the outer mitochondrial membrane, in a redox-dependent manner, leading to binding and bundling of actin. Actin binding and bundling occurs under oxidizing conditions and is reversible under reducing conditions. May be part of a redox-dependent retrograde signal transduction network for adaptation upon oxidative stress (PubMed:23316205). Binds DNA in vitro. UniProt
Catalytic Activity
D-glyceraldehyde 3-phosphate + NAD+ + phosphate = 2R-3-phospho-glyceroyl phosphate + H+ + NADH UniProt
Pathway Maps
      ESCHER  BiGG
Subunit Structure
Homotetramer (By similarity). Interacts with PLDDELTA (PubMed:22589465). Interacts with FBA6 and VDAC3 (PubMed:23316205). UniProt
  • Organism: Mouse-ear cress
  • Length:
  • UniProt
  • Other Gene names: GAPC1, GAPC, GAPDH, At3g04120, T6K12.26
This protein in other organisms (by gene name):
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Data in yellow originates from Pfam  , by interacting with the HMMER3 web site  
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  • Red: potentially disorderd region
  • Blue: probably ordered region.
Hydropathy has been calculated using a sliding window of 15 residues and summing up scores from standard hydrophobicity tables.
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  • Blue: hydrophilic.
Data in lilac represent the genomic exon structure projected onto the UniProt sequence.
Data in blue originates from PDB
  • Secstruc: Secondary structure projected from representative PDB entries onto the UniProt sequence.
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Validation Track

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Data in red indicates combined ranges of Homology Models from the SWISS-MODEL Repository  
The PDB to UniProt mapping is based on the data provided by the EBI SIFTS project. See also Velankar et al., Nucleic Acids Research 33, D262-265 (2005).
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