Protein INCA1 - Q0VD86 (INCA1_HUMAN)


Protein Feature View of PDB entries mapped to a UniProtKB sequence  

Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). UniProt
Pathway Maps
      ESCHER  BiGG
Subunit Structure
Interacts with CCNA1 (PubMed:21540187, PubMed:15159402). Interacts with CCNA2, CCNB1 and CCNE1 (PubMed:21540187). Found in a complex with CCNA1 and CDK2 (PubMed:15159402). Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process (PubMed:21874239). Interacts with SPACA9 (PubMed:18756329). Interacts with the CCNA1/CDK2 complex (PubMed:21540187). Interacts with ING5, DAZAP2, RNF26, USP15, SPOUT1, DPH7, TRIM26 and RAB5C (PubMed:21750715). UniProt
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The PDB to UniProt mapping is based on the data provided by the EBI SIFTS project. See also Velankar et al., Nucleic Acids Research 33, D262-265 (2005).
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