Exploring the influence of the protein environment on metal-binding pharmacophores.
Martin, D.P., Blachly, P.G., McCammon, J.A., Cohen, S.M.(2014) J.Med.Chem. 57: 7126-7135
- PubMed: 25116076 
- DOI: 10.1021/jm500984b
- Primary Citation of Related Structures:  
- PubMed Abstract: 
The binding of a series of metal-binding pharmacophores (MBPs) related to the ligand 1-hydroxypyridine-2-(1H)-thione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated. The presence and/or position of a single ...