5YK2

The complex structure of Rv3197-erythromycin from Mycobacterium tuberculosis


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.807 Å
  • R-Value Free: 0.274 
  • R-Value Work: 0.229 

wwPDB Validation 3D Report Full Report


This is version 1.0 of the entry. See complete history

Literature

Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target.

Zhang, Q.Liu, H.Liu, X.Jiang, D.Zhang, B.Tian, H.Yang, C.Guddat, L.W.Yang, H.Mi, K.Rao, Z.

(2018) Protein Cell --: --


Macromolecules

Find similar proteins by: Sequence  |  Structure

Entity ID: 1
MoleculeChainsSequence LengthOrganismDetails
Probable conserved ATP-binding protein ABC transporter
A
452Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Find proteins for O53343 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Go to UniProtKB:  O53343
Small Molecules
Ligands 1 Unique
IDChainsName / Formula / InChI Key2D Diagram3D Interactions
ERY
Query on ERY

Download SDF File 
Download CCD File 
A
ERYTHROMYCIN A
C37 H67 N O13
ULGZDMOVFRHVEP-RWJQBGPGSA-N
 Ligand Interaction
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.807 Å
  • R-Value Free: 0.274 
  • R-Value Work: 0.229 
  • Space Group: P 63 2 2
Unit Cell:
Length (Å)Angle (°)
a = 187.238α = 90.00
b = 187.238β = 90.00
c = 67.205γ = 120.00
Software Package:
Software NamePurpose
PHASERphasing
HKL-3000data reduction
PHENIXrefinement
HKL-3000data scaling

Structure Validation

View Full Validation Report or Ramachandran Plots



Entry History & Funding Information

Deposition Data

  • Deposited Date: 2017-10-11 
  • Released Date: 2018-02-07 
  • Deposition Author(s): Rao, Z.H., Zhang, Q.Q.

Funding OrganizationCountryGrant Number
State Key Development Program for Basic Research of the Ministry of Science and Technology of ChinaChina2014CB542800
National Natural Science Foundation of ChinaChina81330036
National Natural Science Foundation of ChinaChina81520108019

Revision History 

  • Version 1.0: 2018-02-07
    Type: Initial release