6I9B

NMR structure of the La module from human LARP4A


Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Calculated: 300 
  • Conformers Submitted: 20 
  • Selection Criteria: structures with the lowest energy 

wwPDB Validation 3D Report Full Report


This is version 1.0 of the entry. See complete history

Literature

LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.

Cruz-Gallardo, I.Martino, L.Kelly, G.Atkinson, R.A.Trotta, R.De Tito, S.Coleman, P.Ahdash, Z.Gu, Y.Bui, T.T.T.Conte, M.R.

(2019) Nucleic Acids Res. --: --


Macromolecules

Find similar proteins by: Sequence  |  Structure

Entity ID: 1
MoleculeChainsSequence LengthOrganismDetails
La-related protein 4
A
177Homo sapiensMutation(s): 0 
Gene Names: LARP4
Find proteins for Q71RC2 (Homo sapiens)
Go to Gene View: LARP4
Go to UniProtKB:  Q71RC2
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Calculated: 300 
  • Conformers Submitted: 20 
  • Selection Criteria: structures with the lowest energy 

Structure Validation

View Full Validation Report or Ramachandran Plots



Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
Royal SocietyUnited KingdomNF140482
European Molecular Biology OrganizationUnited KingdomALT400-2010
European CommissionUnited Kingdom655341

Revision History 

  • Version 1.0: 2019-03-13
    Type: Initial release