6PKF

Myocilin OLF mutant N428E/D478K


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 1.484 Å
  • R-Value Free: 0.181 
  • R-Value Work: 0.150 

wwPDB Validation 3D Report Full Report


This is version 1.0 of the entry. See complete history

Literature

Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices

Hill, S.E.Raut, P.Lieberman, R.L.

(2019) Acta Crystallogr.,Sect.D 75: 817-824


Macromolecules

Find similar proteins by: Sequence  |  Structure

Entity ID: 1
MoleculeChainsSequence LengthOrganismDetails
Myocilin
A
277Homo sapiensMutation(s): 2 
Gene Names: MYOC (GLC1A, TIGR)
Find proteins for Q99972 (Homo sapiens)
Go to Gene View: MYOC
Go to UniProtKB:  Q99972
Small Molecules
Ligands 1 Unique
IDChainsName / Formula / InChI Key2D Diagram3D Interactions
GOL
Query on GOL

Download SDF File 
Download CCD File 
A
GLYCEROL
GLYCERIN; PROPANE-1,2,3-TRIOL
C3 H8 O3
PEDCQBHIVMGVHV-UHFFFAOYSA-N
 Ligand Interaction
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 1.484 Å
  • R-Value Free: 0.181 
  • R-Value Work: 0.150 
  • Space Group: P 21 21 21
Unit Cell:
Length (Å)Angle (°)
a = 45.506α = 90.00
b = 58.688β = 90.00
c = 89.505γ = 90.00
Software Package:
Software NamePurpose
PDB_EXTRACTdata extraction
PHASERphasing
HKL-2000data scaling
HKL-2000data reduction
PHENIXrefinement

Structure Validation

View Full Validation Report or Ramachandran Plots



Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
National Institutes of Health/National Eye InstituteUnited StatesR01EY021205

Revision History 

  • Version 1.0: 2019-09-11
    Type: Initial release