Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.
Gradler, U., Schwarz, D., Blaesse, M., Leuthner, B., Johnson, T.L., Bernard, F., Jiang, X., Marx, A., Gilardone, M., Lemoine, H., Roche, D., Jorand-Lebrun, C.(2019) Bioorg.Med.Chem.Lett. 29: 126717-126717
- PubMed: 31635932 
- DOI: 10.1016/j.bmcl.2019.126717
- Primary Citation of Related Structures:  
- PubMed Abstract: 
Fragment-based screening by SPR enabled the discovery of chemical diverse fragment hits with millimolar binding affinities to the peptidyl-prolyl isomerase Cyclophilin D (CypD). The CypD protein crystal structures of 6 fragment hits provided the basi ...