5IT7

Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2


Protein Family Annotation Pfam Database Homepage

ChainsAccessionIdentifierDescriptionCommentsSource
PF00297Ribosomal protein L3 (Ribosomal_L3)Ribosomal protein L3- Family
PF1437460S ribosomal protein L4 C-terminal domain (Ribos_L4_asso_C)60S ribosomal protein L4 C-terminal domainThis family is found at the very C-terminal of 60 ribosomal L4 proteins.Domain
PF00573Ribosomal protein L4/L1 family (Ribosomal_L4)Ribosomal protein L4/L1 family- Family
PF01159Ribosomal protein L6e (Ribosomal_L6e)Ribosomal protein L6e- Family
PF08079Ribosomal L30 N-terminal domain (Ribosomal_L30_N)Ribosomal L30 N-terminal domainThis presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018 [1].Domain
PF00327Ribosomal protein L30p/L7e (Ribosomal_L30)Ribosomal protein L30p/L7eThis family includes prokaryotic L30 and eukaryotic L7.Domain
PF01248Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)Ribosomal protein L7Ae/L30e/S12e/Gadd45 familyThis family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].
Domain
PF00252Ribosomal protein L16p/L10e (Ribosomal_L16)Ribosomal protein L16p/L10e- Domain
PF01929Ribosomal protein L14 (Ribosomal_L14e)Ribosomal protein L14- Family
PF00467KOW motif (KOW)KOW motif- Family
PF00827Ribosomal L15 (Ribosomal_L15e)Ribosomal L15- Family
PF17135Ribosomal protein 60S L18 and 50S L18e (Ribosomal_L18)Ribosomal protein 60S L18 and 50S L18e- Family
PF01280Ribosomal protein L19e (Ribosomal_L19e)Ribosomal protein L19e- Family
PF00238Ribosomal protein L14p/L23e (Ribosomal_L14)Ribosomal protein L14p/L23e- Domain
PF03939Ribosomal protein L23, N-terminal domain (Ribosomal_L23eN)Ribosomal protein L23, N-terminal domain- Family
PF00276Ribosomal protein L23 (Ribosomal_L23)Ribosomal protein L23- Family
PF16906Ribosomal proteins L26 eukaryotic, L24P archaeal (Ribosomal_L26)Ribosomal proteins L26 eukaryotic, L24P archaeal- Family
PF00467KOW motif (KOW)KOW motif- Family
PF01777Ribosomal L27e protein family (Ribosomal_L27e)Ribosomal L27e protein family- Family
PF00828Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A (Ribosomal_L27A)Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A- Family
PF01779Ribosomal L29e protein family (Ribosomal_L29e)Ribosomal L29e protein family- Family
PF01199Ribosomal protein L34e (Ribosomal_L34e)Ribosomal protein L34e- Family
PF00831Ribosomal L29 protein (Ribosomal_L29)Ribosomal L29 protein- Family
PF01781Ribosomal L38e protein family (Ribosomal_L38e)Ribosomal L38e protein family- Family
PF01020Ribosomal L40e family (Ribosomal_L40e)Ribosomal L40e family- Family
PF00687Ribosomal protein L1p/L10e family (Ribosomal_L1)Ribosomal protein L1p/L10e familyThis family includes prokaryotic L1 and eukaryotic L10.Domain
PF00318Ribosomal protein S2 (Ribosomal_S2)Ribosomal protein S2- Family
PF00177Ribosomal protein S7p/S5e (Ribosomal_S7)Ribosomal protein S7p/S5eThis family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.Domain
PF01092Ribosomal protein S6e (Ribosomal_S6e)Ribosomal protein S6e- Family
PF01201Ribosomal protein S8e (Ribosomal_S8e)Ribosomal protein S8e- Family
PF00163Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)Ribosomal protein S4/S9 N-terminal domain- Family
PF01479S4 domain (S4)S4 domainThe S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.
Domain
PF03501Plectin/S10 domain (S10_plectin)Plectin/S10 domainThis presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.Domain
PF08069Ribosomal S13/S15 N-terminal domain (Ribosomal_S13_N)Ribosomal S13/S15 N-terminal domainThis domain is found at the N-terminus of ribosomal S13 and S15 proteins. This domain is also identified as NUC021 [1].Domain
PF00312Ribosomal protein S15 (Ribosomal_S15)Ribosomal protein S15- Domain
PF00203Ribosomal protein S19 (Ribosomal_S19)Ribosomal protein S19- Domain
PF00416Ribosomal protein S13/S18 (Ribosomal_S13)Ribosomal protein S13/S18- Family
PF00338Ribosomal protein S10p/S20e (Ribosomal_S10)Ribosomal protein S10p/S20eThis family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.Domain
PF01249Ribosomal protein S21e (Ribosomal_S21e)Ribosomal protein S21e- Family
PF00410Ribosomal protein S8 (Ribosomal_S8)Ribosomal protein S8- Domain
PF00164Ribosomal protein S12/S23 (Ribosom_S12_S23)Ribosomal protein S12/S23- Family
PF01282Ribosomal protein S24e (Ribosomal_S24e)Ribosomal protein S24e- Family
PF01283Ribosomal protein S26e (Ribosomal_S26e)Ribosomal protein S26e- Family
PF04758Ribosomal protein S30 (Ribosomal_S30)Ribosomal protein S30- Family
PF01599Ribosomal protein S27a (Ribosomal_S27)Ribosomal protein S27aThis family of ribosomal proteins consists mainly of the 40S ribosomal protein S27a which is synthesised as a C-terminal extension of ubiquitin (CEP). The S27a domain compromises the C-terminal half of the protein. The synthesis of ribosomal proteins ...This family of ribosomal proteins consists mainly of the 40S ribosomal protein S27a which is synthesised as a C-terminal extension of ubiquitin (CEP). The S27a domain compromises the C-terminal half of the protein. The synthesis of ribosomal proteins as extensions of ubiquitin promotes their incorporation into nascent ribosomes by a transient metabolic stabilisation and is required for efficient ribosome biogenesis [3]. The ribosomal extension protein S27a contains a basic region that is proposed to form a zinc finger; its fusion gene is proposed as a mechanism to maintain a fixed ratio between ubiquitin necessary for degrading proteins and ribosomes a source of proteins [2].
Domain
PF00347Ribosomal protein L6 (Ribosomal_L6)Ribosomal protein L6- Domain
PF00281Ribosomal protein L5 (Ribosomal_L5)Ribosomal protein L5- Domain
PF00673ribosomal L5P family C-terminus (Ribosomal_L5_C)ribosomal L5P family C-terminusThis region is found associated with Pfam:PF00281.Domain
PF01294Ribosomal protein L13e (Ribosomal_L13e)Ribosomal protein L13e- Family
PF00572Ribosomal protein L13 (Ribosomal_L13)Ribosomal protein L13- Family
PF00237Ribosomal protein L22p/L17e (Ribosomal_L22)Ribosomal protein L22p/L17eThis family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.Domain
PF01157Ribosomal protein L21e (Ribosomal_L21e)Ribosomal protein L21e- Family
PF01776Ribosomal L22e protein family (Ribosomal_L22e)Ribosomal L22e protein family- Family
PF01246Ribosomal protein L24e (Ribosomal_L24e)Ribosomal protein L24e- Domain
PF01248Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)Ribosomal protein L7Ae/L30e/S12e/Gadd45 familyThis family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].
Domain
PF01198Ribosomal protein L31e (Ribosomal_L31e)Ribosomal protein L31e- Family
PF01655Ribosomal protein L32 (Ribosomal_L32e)Ribosomal protein L32- Family
PF01247Ribosomal protein L35Ae (Ribosomal_L35Ae)Ribosomal protein L35Ae- Domain
PF01158Ribosomal protein L36e (Ribosomal_L36e)Ribosomal protein L36e- Family
PF01907Ribosomal protein L37e (Ribosomal_L37e)Ribosomal protein L37e- Family
PF03947Ribosomal Proteins L2, C-terminal domain (Ribosomal_L2_C)Ribosomal Proteins L2, C-terminal domain- Domain
PF00181Ribosomal Proteins L2, RNA binding domain (Ribosomal_L2)Ribosomal Proteins L2, RNA binding domain- Domain
PF00832Ribosomal L39 protein (Ribosomal_L39)Ribosomal L39 protein- Family
PF05162Ribosomal protein L41 (Ribosomal_L41)Ribosomal protein L41- Family
PF00935Ribosomal protein L44 (Ribosomal_L44)Ribosomal protein L44- Family
PF01780Ribosomal L37ae protein family (Ribosomal_L37ae)Ribosomal L37ae protein family- Family
PF17777Insertion domain in 60S ribosomal protein L10P (RL10P_insert)Insertion domain in 60S ribosomal protein L10PThis domain is found in prokaryotic and archaeal ribosomal L10 protein [1].Domain
PF00466Ribosomal protein L10 (Ribosomal_L10)Ribosomal protein L10- Family
PF01015Ribosomal S3Ae family (Ribosomal_S3Ae)Ribosomal S3Ae family- Family
PF03719Ribosomal protein S5, C-terminal domain (Ribosomal_S5_C)Ribosomal protein S5, C-terminal domain- Domain
PF00333Ribosomal protein S5, N-terminal domain (Ribosomal_S5)Ribosomal protein S5, N-terminal domain- Domain
PF07650KH domain (KH_2)KH domain- Domain
PF00189Ribosomal protein S3, C-terminal domain (Ribosomal_S3_C)Ribosomal protein S3, C-terminal domainThis family contains a central domain Pfam:PF00013, hence the amino and carboxyl terminal domains are stored separately. This is a minimal carboxyl-terminal domain. Some are much longer.Domain
PF00900Ribosomal family S4e (Ribosomal_S4e)Ribosomal family S4e- Family
PF1612140S ribosomal protein S4 C-terminus (40S_S4_C)40S ribosomal protein S4 C-terminus- Family
PF08071RS4NT (NUC023) domain (RS4NT)RS4NT (NUC023) domainThis is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains [1].Domain
PF01479S4 domain (S4)S4 domainThe S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.
Domain
PF00467KOW motif (KOW)KOW motif- Family
PF01251Ribosomal protein S7e (Ribosomal_S7e)Ribosomal protein S7e- Family
PF16205Ribosomal_S17 N-terminal (Ribosomal_S17_N)Ribosomal_S17 N-terminal- Family
PF00366Ribosomal protein S17 (Ribosomal_S17)Ribosomal protein S17- Domain
PF01248Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)Ribosomal protein L7Ae/L30e/S12e/Gadd45 familyThis family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].
Domain
PF00411Ribosomal protein S11 (Ribosomal_S11)Ribosomal protein S11- Family
PF00380Ribosomal protein S9/S16 (Ribosomal_S9)Ribosomal protein S9/S16- Family
PF00833Ribosomal S17 (Ribosomal_S17e)Ribosomal S17- Family
PF01090Ribosomal protein S19e (Ribosomal_S19e)Ribosomal protein S19e- Family
PF17144Ribosomal large subunit proteins 60S L5, and 50S L18 (Ribosomal_L5e)Ribosomal large subunit proteins 60S L5, and 50S L18- Family
PF14204Ribosomal L18 C-terminal region (Ribosomal_L18_c)Ribosomal L18 C-terminal regionThis domain is the C-terminal end of ribosomal L18/L5 proteins.Domain
PF03297S25 ribosomal protein (Ribosomal_S25)S25 ribosomal protein- Family
PF01667Ribosomal protein S27 (Ribosomal_S27e)Ribosomal protein S27- Family
PF01200Ribosomal protein S28e (Ribosomal_S28e)Ribosomal protein S28e- Family
PF00253Ribosomal protein S14p/S29e (Ribosomal_S14)Ribosomal protein S14p/S29e- Family
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat

Gene Product Annotation Gene Product Annotation

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
25S ribosomal RNAnonenonenone
5S ribosomal RNAnonenonenone
60S ribosomal protein L3
    KLLA0B07139p
      KLLA0B04686p
        KLLA0D03410p
          KLLA0E00573p
          KLLA0D05643p
            KLLA0B13409p
              Ribosomal protein L15
                KLLA0A07227p
                  KLLA0E12453p
                    60S ribosomal protein L20nonenonenone
                    KLLA0E06997p
                      60S ribosomal protein L25
                        KLLA0B05742p
                          KLLA0E03455p
                            RPL28
                              KLLA0D16071p
                                KLLA0C08371p
                                  KLLA0F05247p
                                    KLLA0C18216p
                                      Ubiquitin fusion protein
                                        Ribosomal protein
                                          40S ribosomal protein S0
                                            KLLA0D10659p
                                              40S ribosomal protein S6
                                                40S ribosomal protein S8
                                                  KLLA0E23673p
                                                    KLLA0B08173p
                                                        KLLA0F18040p
                                                          KLLA0F07843p
                                                            KLLA0B01562p
                                                              KLLA0F25542p
                                                                40S ribosomal protein S21
                                                                  40S ribosomal protein S22
                                                                    RPS23
                                                                      40S ribosomal protein S24
                                                                        KLLA0D05115p
                                                                          KLLA0C04809p
                                                                            Ubiquitin-40S ribosomal protein S27a
                                                                              18S ribosomal RNAnonenonenone
                                                                              Eft2pnonenonenone
                                                                              KLLA0F04499p
                                                                                KLLA0F08261p
                                                                                  60S ribosomal protein L13
                                                                                    KLLA0F04675p
                                                                                      KLLA0A06336p
                                                                                        KLLA0E23651p
                                                                                          KLLA0D05181p
                                                                                            60S ribosomal protein L24
                                                                                                5.8S ribosomal RNAnonenonenone
                                                                                                60S ribosomal protein L30
                                                                                                  KLLA0B02937p
                                                                                                    KLLA0E06843p
                                                                                                      KLLA0D07405p
                                                                                                        60S ribosomal protein L36
                                                                                                          Ribosomal protein L37
                                                                                                            KLLA0D16027p
                                                                                                              60S ribosomal protein L39
                                                                                                                60S ribosomal protein L41-A
                                                                                                                  60S ribosomal protein L44
                                                                                                                  KLLA0E05941p
                                                                                                                    60S acidic ribosomal protein P0
                                                                                                                      uL11nonenonenone
                                                                                                                      40S ribosomal protein S1
                                                                                                                        KLLA0F09812p
                                                                                                                          KLLA0D08305p
                                                                                                                            40S ribosomal protein S4
                                                                                                                              KLLA0C13519p
                                                                                                                                KLLA0A10483p
                                                                                                                                  40S ribosomal protein S12
                                                                                                                                    40S ribosomal protein S14
                                                                                                                                      40S ribosomal protein S16
                                                                                                                                        KLLA0B01474p
                                                                                                                                          KLLA0A07194p
                                                                                                                                            KLLA0D06941p
                                                                                                                                              KLLA0B06182p
                                                                                                                                                  40S ribosomal protein S27
                                                                                                                                                    40S ribosomal protein S28
                                                                                                                                                      40S ribosomal protein S29
                                                                                                                                                        KLLA0E12277p
                                                                                                                                                        cricket paralysis virus IRESnonenonenone