Annotations: 1QX5

Domain Annotation: SCOP/SCOPe Classification SCOP Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth D]	d1qx5d_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth I]	d1qx5i_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C [auth B]	d1qx5b_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D [auth J]	d1qx5j_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
E [auth K]	d1qx5k_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
F [auth T]	d1qx5t_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
G [auth R]	d1qx5r_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
H [auth Y]	d1qx5y_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth D]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
B [auth I]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
D [auth J]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
E [auth K]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
F [auth T]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
G [auth R]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
H [auth Y]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	EF-hand_7_8	e1qx5D2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
A [auth D]	EF-hand_7_5	e1qx5D1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
B [auth I]	EF-hand_7_8	e1qx5I2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
B [auth I]	EF-hand_7_5	e1qx5I1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
C [auth B]	EF-hand_7_8	e1qx5B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
C [auth B]	EF-hand_7_5	e1qx5B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
D [auth J]	EF-hand_7_8	e1qx5J2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
D [auth J]	EF-hand_7_5	e1qx5J1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
E [auth K]	EF-hand_7_8	e1qx5K2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
E [auth K]	EF-hand_7_5	e1qx5K1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
F [auth T]	EF-hand_7_8	e1qx5T2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
F [auth T]	EF-hand_7_5	e1qx5T1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
G [auth R]	EF-hand_7_8	e1qx5R2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
G [auth R]	EF-hand_7_5	e1qx5R1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
H [auth Y]	EF-hand_7_8	e1qx5Y2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
H [auth Y]	EF-hand_7_5	e1qx5Y1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)
B [auth I]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)
C [auth B]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)
D [auth J]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)
E [auth K]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)
F [auth T]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)
G [auth R]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)
H [auth Y]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.2.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	Calmodulin	enzyme activator activity cyclase regulator activity cyclase activator activity adenylate cyclase regulator activity adenylate cyclase activator activity enzyme regulator activity molecular function regulator activity molecular function activator activity binding protein binding adenylate cyclase binding enzyme binding calcium channel regulator activity ion channel inhibitor activity channel regulator activity channel inhibitor activity calcium channel inhibitor activity ion channel regulator activity molecular function inhibitor activity calcium ion binding ion binding cation binding metal ion binding calcium-dependent protein binding protein domain specific binding disordered domain specific binding nitric-oxide synthase binding nitric-oxide synthase regulator activity phosphatidylinositol 3-kinase binding kinase binding protein kinase binding phosphatase regulator activity phosphatase activator activity protein phosphatase regulator activity protein phosphatase activator activity cytoskeletal protein binding titin binding transmembrane transporter binding	cellular process cellular component organization membrane docking localization organelle localization cellular component organization or biogenesis organelle localization by membrane tethering mitochondrion-endoplasmic reticulum membrane tethering cell death programmed cell death regulation of programmed cell death positive regulation of programmed cell death autophagic cell death positive regulation of biological process positive regulation of cellular process regulation of biological process regulation of cellular process biological regulation regulation of autophagic cell death positive regulation of autophagic cell death positive regulation of catalytic activity positive regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of cyclic-nucleotide phosphodiesterase activity positive regulation of cyclic-nucleotide phosphodiesterase activity positive regulation of hydrolase activity regulation of molecular function positive regulation of DNA binding regulation of binding positive regulation of binding regulation of DNA binding regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity response to organic substance response to inorganic substance response to metal ion response to chemical response to stimulus response to calcium ion response to oxygen-containing compound response to salt	membrane protein-containing complex monoatomic ion channel complex cation channel complex calcium channel complex membrane protein complex cellular anatomical entity transmembrane transporter complex transporter complex catalytic complex intracellular anatomical structure centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cytoplasm cytosol transferase complex, transferring phosphorus-containing groups serine/threonine protein kinase complex protein kinase complex transferase complex DAPK1-calmodulin complex axon growth cone site of polarized growth cell projection neuron projection plasma membrane bounded cell projection distal axon mitochondrion membrane-bounded organelle intracellular membrane-bounded organelle myelin sheath nucleus nucleoplasm membrane-enclosed lumen nuclear lumen organelle lumen intracellular organelle lumen plasma membrane cell periphery myofibril sarcomere contractile fiber supramolecular complex supramolecular polymer supramolecular fiber cilium motile cilium sperm flagellum sperm midpiece 9+2 motile cilium spindle microtubule spindle microtubule polymeric cytoskeletal fiber vesicle voltage-gated potassium channel complex potassium channel complex plasma membrane protein complex

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.