1QX5 | pdb_00001qx5

Crystal structure of apoCalmodulin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth D]	d1qx5d_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth I]	d1qx5i_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C [auth B]	d1qx5b_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D [auth J]	d1qx5j_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
E [auth K]	d1qx5k_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
F [auth T]	d1qx5t_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
G [auth R]	d1qx5r_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
H [auth Y]	d1qx5y_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth D]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
B [auth I]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
D [auth J]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
E [auth K]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
F [auth T]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
G [auth R]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)
H [auth Y]	SCOP2B Superfamily	EF-hand	8032568	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	EF-hand_7_8	e1qx5D2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
A [auth D]	EF-hand_7_5	e1qx5D1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
B [auth I]	EF-hand_7_8	e1qx5I2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
B [auth I]	EF-hand_7_5	e1qx5I1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
C [auth B]	EF-hand_7_8	e1qx5B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
C [auth B]	EF-hand_7_5	e1qx5B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
D [auth J]	EF-hand_7_8	e1qx5J2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
D [auth J]	EF-hand_7_5	e1qx5J1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
E [auth K]	EF-hand_7_8	e1qx5K2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
E [auth K]	EF-hand_7_5	e1qx5K1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
F [auth T]	EF-hand_7_8	e1qx5T2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
F [auth T]	EF-hand_7_5	e1qx5T1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
G [auth R]	EF-hand_7_8	e1qx5R2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
G [auth R]	EF-hand_7_5	e1qx5R1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)
H [auth Y]	EF-hand_7_8	e1qx5Y2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
H [auth Y]	EF-hand_7_5	e1qx5Y1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B [auth I]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C [auth B]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D [auth J]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
E [auth K]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
F [auth T]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
G [auth R]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
H [auth Y]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	Calmodulin	cytoskeletal protein binding titin binding protein binding binding phosphoric ester hydrolase activity enzyme regulator activity protein phosphatase activator activity catalytic activity, acting on a protein phosphatase activator activity molecular function activator activity phosphatase activity phosphatase regulator activity hydrolase activity phosphoprotein phosphatase activity cytoskeletal protein binding titin binding protein binding binding phosphoric ester hydrolase activity enzyme regulator activity protein phosphatase activator activity catalytic activity, acting on a protein phosphatase activator activity molecular function activator activity phosphatase activity phosphatase regulator activity hydrolase activity phosphoprotein phosphatase activity enzyme activator activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity enzyme binding adenylate cyclase binding phosphatidylinositol 3-kinase binding calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transporter regulator activity transmembrane transporter activity oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen nitric-oxide synthase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen nitric-oxide synthase regulator activity molecular function inhibitor activity transporter inhibitor activity calcium channel inhibitor activity channel inhibitor activity ion channel inhibitor activity phosphorus-oxygen lyase activity cyclase regulator activity cyclase activator activity cyclase activity adenylate cyclase regulator activity lyase activity adenylate cyclase activator activity adenylate cyclase activity protein serine/threonine kinase activity protein serine/threonine kinase activator activity kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups kinase activator activity protein kinase activator activity kinase regulator activity nitric-oxide synthase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein domain specific binding signaling receptor binding type 3 metabotropic glutamate receptor binding glutamate receptor binding G protein-coupled receptor binding G protein-coupled glutamate receptor binding transmembrane transporter binding kinase binding protein kinase binding calcium-dependent protein binding	organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity intracellular calcium ion homeostasis negative regulation of biological process negative regulation of ryanodine-sensitive calcium-release channel activity negative regulation of transport calcium ion transport negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport regulation of molecular function release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis transport negative regulation of cation channel activity homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport positive regulation of biological process regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport regulation of transporter activity maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis negative regulation of cellular process monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion positive regulation of cellular process regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion negative regulation of transporter activity negative regulation of molecular function negative regulation of calcium ion transport cellular homeostasis regulation of ryanodine-sensitive calcium-release channel activity regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport response to stimulus response to metal ion response to chemical response to calcium ion protein localization establishment of protein localization establishment of protein localization to mitochondrial membrane mitochondrial membrane organization cellular component organization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis mitochondrion organization membrane organization establishment of protein localization to membrane localization within membrane protein localization to membrane organelle organization establishment of protein localization to organelle macromolecule localization protein localization to organelle protein localization to mitochondrion establishment of protein localization to mitochondrion sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cellular component disassembly catabolic process protein-containing complex organization macroautophagy autophagy protein-containing complex disassembly autophagosome maturation autophagosome membrane docking metabolic process process utilizing autophagic mechanism import into cell regulation of cellular component organization synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling regulation of synaptic vesicle endocytosis regulation of endocytosis synaptic vesicle endocytosis regulation of vesicle-mediated transport endocytosis cellular response to interferon-beta response to peptide response to interferon-beta response to cytokine cellular response to cytokine stimulus regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process mitochondrion-endoplasmic reticulum membrane tethering cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition mitotic cell cycle mitotic cell cycle phase transition regulated exocytosis modulation of chemical synaptic transmission signaling synaptic vesicle exocytosis cell communication regulation of regulated secretory pathway synaptic signaling regulation of secretion by cell secretion by cell signal release trans-synaptic signaling regulation of signaling neurotransmitter secretion secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis export from cell cell-cell signaling neurotransmitter transport regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling exocytosis regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of exocytosis regulation of cell communication regulation of cardiac muscle contraction cardiac muscle contraction muscle contraction muscle system process regulation of muscle system process striated muscle contraction regulation of striated muscle contraction regulation of muscle contraction biological process involved in interspecies interaction between organisms immune response response to other organism defense response response to type II interferon defense response to symbiont response to external stimulus cellular response to type II interferon response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus cellular response to stimulus positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT regulation of signal transduction positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT signal transduction cell surface receptor signaling pathway regulation of response to stimulus regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling regulation of action potential regulation of cardiac muscle cell action potential action potential cardiac muscle cell action potential regulation of membrane potential response to amine response to nitrogen compound response to amphetamine detection of stimulus detection of chemical stimulus detection of calcium ion	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cytoplasm cytosol membrane-bounded organelle cell projection intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton cytoplasm cytosol membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection protein-containing complex transmembrane transporter complex membrane membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex axon synapse neuron projection axon terminus presynapse distal axon calyx of Held cell junction neuron projection terminus sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex mitochondrion intracellular membrane-bounded organelle myelin sheath centrosome microtubule organizing center cytosolic region presynaptic cytosol catalytic complex growth cone site of polarized growth nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen voltage-gated potassium channel complex plasma membrane protein complex plasma membrane potassium channel complex cell periphery Schaffer collateral - CA1 synapse polymeric cytoskeletal fiber spindle microtubule microtubule postsynapse postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	IPR002048	EF-hand domain	Domain
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	IPR050230	Calmodulin/Myosin light chain/Troponin C-like	Family
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], A [auth D], B [auth I], C [auth B], D [auth J], E [auth K], F [auth T], G [auth R], H [auth Y]	IPR011992	EF-hand domain pair	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.