Annotations: 3P0G

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8091149	4001858	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_3	e3p0gA1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
B	V-set_1	e3p0gB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.2.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.2.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	VHH, anti-gp5-ADRB2	VH	Lama glama (llama)	IGHV3S301, IGHJ401	V-DOMAIN VH	IG	(VH)	IMGT (202307-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	beta-2 adrenergic receptor, lysozyme	SAbDab (2023-03-01)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Beta-2 adrenergic receptor, Lysozyme	lysozyme activity catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity binding protein binding adenylate cyclase binding enzyme binding transmembrane signaling receptor activity G protein-coupled receptor activity adrenergic receptor activity beta-adrenergic receptor activity beta2-adrenergic receptor activity G protein-coupled amine receptor activity signaling receptor activity molecular transducer activity identical protein binding ion binding cation binding norepinephrine binding organic cyclic compound binding catecholamine binding potassium channel regulator activity channel regulator activity molecular function regulator activity ion channel regulator activity protein homodimerization activity protein dimerization activity protein-containing complex binding	metabolic process catabolic process macromolecule catabolic process cellular process cell wall macromolecule catabolic process macromolecule metabolic process cell wall macromolecule metabolic process cell wall organization or biogenesis organic substance metabolic process organic substance catabolic process cytolysis cell differentiation developmental process fat cell differentiation cellular developmental process brown fat cell differentiation response to endogenous stimulus response to organic substance response to organonitrogen compound response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to organic substance cellular response to organonitrogen compound cellular response to endogenous stimulus response to peptide cellular response to peptide response to nitrogen compound cellular response to nitrogen compound response to oxygen-containing compound cellular response to oxygen-containing compound response to amyloid-beta cellular response to amyloid-beta multicellular organismal process multicellular organism growth growth regulation of growth regulation of multicellular organism growth negative regulation of multicellular organism growth negative regulation of growth negative regulation of biological process developmental growth regulation of developmental growth negative regulation of developmental growth regulation of biological process regulation of developmental process negative regulation of developmental process regulation of multicellular organismal process negative regulation of multicellular organismal process biological regulation	host cellular component host cell cytoplasm host cell part host intracellular part host intracellular region host cell cellular anatomical entity plasma membrane membrane apical plasma membrane apical part of cell cell periphery plasma membrane region intracellular anatomical structure cytoplasm vesicle membrane coated vesicle clathrin-coated vesicle endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane clathrin-coated vesicle membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane organelle membrane cytoplasmic vesicle vesicle organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle clathrin-coated endocytic vesicle intracellular vesicle bounding membrane of organelle endosome early endosome endomembrane system endosome membrane Golgi apparatus nucleus protein-containing complex receptor complex
B	Camelid Antibody Fragment	none	none	none

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	β₂ adrenergic receptor (engineered) in nanobody-stabilized active state

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.