Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyMacro domain-like8036145 3000458 SCOP2B (2022-02-25)
CSCOP2B SuperfamilyMacro domain-like8036145 3000458 SCOP2B (2022-02-25)
DSCOP2B SuperfamilyMacro domain-like8036145 3000458 SCOP2B (2022-02-25)
BSCOP2B SuperfamilyMacro domain-like8036145 3000458 SCOP2B (2022-02-25)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASPXe5iitA2 A: alpha bundlesX: SPX domain (From Topology)H: SPX domain (From Topology)T: SPX domainF: SPXECOD (1.6)
AMacroe5iitA1 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: MacroECOD (1.6)
CSPXe5iitC2 A: alpha bundlesX: SPX domain (From Topology)H: SPX domain (From Topology)T: SPX domainF: SPXECOD (1.6)
CMacroe5iitC1 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: MacroECOD (1.6)
DSPXe5iitD2 A: alpha bundlesX: SPX domain (From Topology)H: SPX domain (From Topology)T: SPX domainF: SPXECOD (1.6)
DMacroe5iitD1 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: MacroECOD (1.6)
BSPXe5iitB2 A: alpha bundlesX: SPX domain (From Topology)H: SPX domain (From Topology)T: SPX domainF: SPXECOD (1.6)
BMacroe5iitB1 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: MacroECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionIdentifierDescriptionCommentsSource
A, B, C, D PF01661Macro domain (Macro)Macro domainThe Macro or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose (an NAD metabolite) or related ligands. Binding to ADP-ribose could be either covalent or non-covalent [1]: in certain cases it is believed to bind non-covalently ...The Macro or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose (an NAD metabolite) or related ligands. Binding to ADP-ribose could be either covalent or non-covalent [1]: in certain cases it is believed to bind non-covalently [2]; while in other cases (such as Aprataxin) it appears to bind both non-covalently through a zinc finger motif, and covalently through a separate region of the protein [3]. This domain is found in a number of otherwise unrelated proteins. It is found at the C-terminus of the macro-H2A histone protein 4 and also in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alpha-viruses and coronaviruses. This domain is also found on its own in a family of proteins from bacteria, archaebacteria and eukaryotes. The 3D structure of the SARS-CoV Macro domain has a mixed alpha/beta fold consisting of a central seven-stranded twisted mixed beta sheet sandwiched between two alpha helices on one face, and three on the other. The final alpha-helix, located on the edge of the central beta-sheet, forms the C terminus of the protein [4]. The crystal structure of AF1521 (a Macro domain-only protein from Archaeoglobus fulgidus) has also been reported and compared with other Macro domain containing proteins. Several Macro domain only proteins are shorter than AF1521, and appear to lack either the first strand of the beta-sheet or the C-terminal helix 5. Well conserved residues form a hydrophobic cleft and cluster around the AF1521-ADP-ribose binding site [5].
Domain

Gene Product Annotation Gene Product Annotation

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D Vacuolar transporter chaperone 4,Core histone macro-H2A.1