5SBL

CD44 PanDDA analysis group deposition -- The hyaluronan-binding domain of CD44 in complex with Z126932614

Present annotations:

Domain Annotation: ECOD Classification
Gene Product Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5sblA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CD44 antigen	signaling receptor binding epidermal growth factor receptor binding binding protein binding growth factor receptor binding glycosaminoglycan binding hyaluronic acid binding carbohydrate derivative binding phosphoprotein binding enzyme binding kinase binding protein kinase binding transmembrane signaling receptor activity signaling receptor activity molecular transducer activity type II transforming growth factor beta receptor binding cytokine receptor binding transforming growth factor beta receptor binding	response to endogenous stimulus cellular process response to organic substance response to chemical cellular response to fibroblast growth factor stimulus response to stimulus cellular response to stimulus response to growth factor cellular response to chemical stimulus cellular response to organic substance cellular response to growth factor stimulus cellular response to endogenous stimulus response to fibroblast growth factor metabolic process positive regulation of metabolic process gene expression regulation of gene expression positive regulation of macromolecule metabolic process positive regulation of gene expression regulation of metabolic process macromolecule metabolic process positive regulation of biological process regulation of biological process regulation of macromolecule metabolic process biological regulation organic substance metabolic process	plasma membrane membrane apical plasma membrane apical part of cell cell periphery plasma membrane region cellular anatomical entity basal plasma membrane basolateral plasma membrane basal part of cell cell projection cell surface intracellular anatomical structure cytoplasm cytosol external side of plasma membrane side of membrane Golgi apparatus endomembrane system organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle integral component of membrane intrinsic component of membrane lamellipodium cell leading edge cell projection membrane leading edge membrane lamellipodium membrane plasma membrane bounded cell projection protein-containing complex macrophage migration inhibitory factor receptor complex receptor complex microvillus actin-based cell projection nucleus

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.