Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyOuter membrane efflux proteins (OEP)8037933 3000246 SCOP2B (2022-02-25)
BSCOP2B SuperfamilyOuter membrane efflux proteins (OEP)8037933 3000246 SCOP2B (2022-02-25)
CSCOP2B SuperfamilyOuter membrane efflux proteins (OEP)8037933 3000246 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains)8042531 3000526 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042529 3000503 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042534 3000769 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042535 3000769 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042529 3000503 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042534 3000769 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042525 3000503 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042525 3000503 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains)8042533 3000526 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042535 3000769 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042528 3000503 SCOP2B (2022-02-25)
JSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042523 3000503 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042534 3000769 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042523 3000503 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042534 3000769 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042529 3000503 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042528 3000503 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042535 3000769 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042529 3000503 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains)8042533 3000526 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042535 3000769 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains)8042531 3000526 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042525 3000503 SCOP2B (2022-02-25)
KSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042525 3000503 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042525 3000503 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042535 3000769 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042529 3000503 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains)8042533 3000526 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042535 3000769 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains)8042531 3000526 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042525 3000503 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042534 3000769 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042529 3000503 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain8042534 3000769 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042523 3000503 SCOP2B (2022-02-25)
LSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1 PN2 PC1 and PC2 subdomains8042528 3000503 SCOP2B (2022-02-25)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AOEPe5v5sA1 A: a+b duplicates or obligate multimersX: Outer membrane efflux proteins (OEP) (From Topology)H: Outer membrane efflux proteins (OEP) (From Topology)T: Outer membrane efflux proteins (OEP)F: OEPECOD (1.6)
BOEPe5v5sB1 A: a+b duplicates or obligate multimersX: Outer membrane efflux proteins (OEP) (From Topology)H: Outer membrane efflux proteins (OEP) (From Topology)T: Outer membrane efflux proteins (OEP)F: OEPECOD (1.6)
COEPe5v5sC1 A: a+b duplicates or obligate multimersX: Outer membrane efflux proteins (OEP) (From Topology)H: Outer membrane efflux proteins (OEP) (From Topology)T: Outer membrane efflux proteins (OEP)F: OEPECOD (1.6)
DPRK15030_2nde5v5sD1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
DHlyD_D23_C_1e5v5sD3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
DHlyD_2nde5v5sD2 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
DHlyD_1ste5v5sD4 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
EPRK15030_2nde5v5sE4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
EHlyD_D23_C_1e5v5sE1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
EHlyD_2nde5v5sE2 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
EHlyD_1ste5v5sE3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
FPRK15030_2nde5v5sF3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
FHlyD_D23_C_1e5v5sF1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
FHlyD_2nde5v5sF2 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
FHlyD_1ste5v5sF4 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
GPRK15030_2nde5v5sG3 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
GHlyD_D23_C_1e5v5sG1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
GHlyD_2nde5v5sG4 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
GHlyD_1ste5v5sG2 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
HPRK15030_2nde5v5sH2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
HHlyD_D23_C_1e5v5sH4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
HHlyD_2nde5v5sH1 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
HHlyD_1ste5v5sH3 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
IPRK15030_2nde5v5sI2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: PRK15030_2ndECOD (1.6)
IHlyD_D23_C_1e5v5sI4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: HlyD_D23_C_1ECOD (1.6)
IHlyD_2nde5v5sI3 A: alpha bundlesX: helical hairpin of HlyD-like secretion proteins (From Topology)H: helical hairpin of HlyD-like secretion proteins (From Topology)T: helical hairpin of HlyD-like secretion proteinsF: HlyD_2ndECOD (1.6)
IHlyD_1ste5v5sI1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: HlyD_1stECOD (1.6)
JACR_tran_4the5v5sJ6 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
JACR_tran_1ste5v5sJ5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
JACR_tran_5the5v5sJ3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
JACR_tran_3rde5v5sJ8 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
JACR_tran_6the5v5sJ4 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
JACR_tran_2nde5v5sJ1 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
JACR_tran_6th_1e5v5sJ2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
KACR_tran_4the5v5sK1 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
KACR_tran_1ste5v5sK4 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
KACR_tran_5the5v5sK8 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
KACR_tran_3rde5v5sK2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
KACR_tran_6the5v5sK7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
KACR_tran_2nde5v5sK6 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
KACR_tran_6th_1e5v5sK3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
LACR_tran_4the5v5sL2 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
LACR_tran_1ste5v5sL7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
LACR_tran_5the5v5sL5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
LACR_tran_3rde5v5sL1 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
LACR_tran_6the5v5sL6 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
LACR_tran_2nde5v5sL3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
LACR_tran_6th_1e5v5sL4 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionIdentifierDescriptionCommentsSource
A, B, C PF02321Outer membrane efflux protein (OEP)Outer membrane efflux protein- Family
D, E, F, G, H, I
PF00529Cation efflux system protein CusB domain 1 (CusB_dom_1)Cation efflux system protein CusB domain 1- Family
D, E, F, G, H, I
PF16576Barrel-sandwich domain of CusB or HlyD membrane-fusion (HlyD_D23)Barrel-sandwich domain of CusB or HlyD membrane-fusionHlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole ...HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Domain
J, K, L PF00873AcrB/AcrD/AcrF family (ACR_tran)AcrB/AcrD/AcrF family- Family

Gene Product Annotation Gene Product Annotation

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C Outer membrane protein TolC
D, E, F, G, H, I
Multidrug efflux pump subunit AcrA
J, K, L Multidrug efflux pump subunit AcrB

    Membrane Protein Annotation: OPM OPM Database Homepage

    ChainsExternal LinkTypeClassSuperfamilyFamily
    A, B, C, D, E, F, G, H
    OPMTransmembraneAlpha-helical polytopicResistance-nodulation-cell divisionHydrophobe/amphiphile efflux-1 family

    Membrane Protein Annotation: PDBTM PDBTM Database Homepage

    ChainsExternal LinkComment
    A, B, C, D, E, F, G, H
    PDBTMAnnotated as membrane protein by PDBTM