5VEU

Human Cytochrome P450 3A5 (CYP3A5)

Present annotations:

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Product Annotation
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
G	d5veug_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5veua_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5veub_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5veuc_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5veud_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d5veue_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d5veuf_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d5veuh_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d5veui_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d5veuj_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d5veuk_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d5veul_	All alpha proteins	Cytochrome P450	Cytochrome P450	Cytochrome P450	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
A	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
B	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
C	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
D	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
E	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
F	SCOP2 Family	Cytochrome P450	8068662	4001206	SCOP2 (2022-02-25)
F	SCOP2 Superfamily	Cytochrome P450	8068663	3001061	SCOP2 (2022-02-25)
H	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
I	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
J	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
K	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)
L	SCOP2B Superfamily	Cytochrome P450	8068663	3001061	SCOP2B (2022-02-25)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G	p450	e5veuG1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
A	p450	e5veuA1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
B	p450	e5veuB1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
C	p450	e5veuC1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
D	p450	e5veuD1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
E	p450	e5veuE1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
F	p450	e5veuF1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
H	p450	e5veuH1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
I	p450	e5veuI1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
J	p450	e5veuJ1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
K	p450	e5veuK1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)
L	p450	e5veuL1	A: alpha arrays	X: Cytochrome P450 (From Topology)	H: Cytochrome P450 (From Topology)	T: Cytochrome P450	F: p450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
A	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
B	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
C	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
D	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
E	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
F	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
H	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
I	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
J	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
K	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)
L	1.10.630.10	Mainly Alpha	Orthogonal Bundle	Cytochrome p450	Cytochrome P450	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A, B, C, D, E, F, G, H, I, J, K, L A, B, C, D, E, F, G, H, I, J, K, L	PF00067	Cytochrome P450 (p450)	Cytochrome P450	Cytochrome P450s are haem-thiolate proteins [6] involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, a ...	Cytochrome P450s are haem-thiolate proteins [6] involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures [6].	DomainDomain

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E, F, G, H, I, J, K, L A, B, C, D, E, F, G, H, I, J, K, L	Cytochrome P450 3A5	catalytic activity monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen aromatase activity steroid hydroxylase activity estrogen 16-alpha-hydroxylase activity binding heme binding tetrapyrrole binding organic cyclic compound binding heterocyclic compound binding iron ion binding ion binding cation binding metal ion binding transition metal ion binding oxygen binding small molecule binding retinoic acid 4-hydroxylase activity	metabolic process toxin metabolic process cellular process secondary metabolic process mycotoxin metabolic process cellular metabolic process aflatoxin metabolic process heterocycle metabolic process organic substance metabolic process organic cyclic compound metabolic process organic heteropentacyclic compound metabolic process demethylation oxidative demethylation	intracellular anatomical structure cytoplasm endoplasmic reticulum endoplasmic reticulum membrane endomembrane system membrane organelle membrane organelle subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle endoplasmic reticulum subcompartment cellular anatomical entity

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E, F, G, H A, B, C, D, E, F, G, H, I, J, K, L	OPM				Cytochrome P450

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.