6N48

Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator

Present annotations:

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Product Annotation
InterPro Annotation
Disease Associations: Pharos
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_3	e6n48A2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
A	Phage_lysozyme_2	e6n48A1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	V-set_1	e6n48B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_1	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	Antibody Fab Fragment	VH	Vicugna pacos (alpaca)	IGHV3S5301, IGHJ401	V-DOMAIN VH	IG	VH	IMGT (202346-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	endolysin,beta-2 adrenergic receptor,beta-2 adrenergicreceptor chimera	SAbDab (2023-11-24)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera	amide binding amyloid-beta binding binding peptide binding protein binding enzyme binding adenylate cyclase binding G protein-coupled amine receptor activity molecular transducer activity beta2-adrenergic receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity amide binding amyloid-beta binding binding peptide binding protein binding enzyme binding adenylate cyclase binding G protein-coupled amine receptor activity molecular transducer activity beta2-adrenergic receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity adrenergic receptor activity protein-containing complex binding potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity identical protein binding protein homodimerization activity protein dimerization activity cation binding ion binding catecholamine binding organic cyclic compound binding norepinephrine binding	response to extracellular stimulus multicellular organismal process response to nutrient levels response to stimulus homeostatic process response to external stimulus adaptive thermogenesis multicellular organismal-level homeostasis response to dietary excess diet induced thermogenesis metabolic process energy homeostasis cellular response to stimulus regulation of localization response to extracellular stimulus multicellular organismal process response to nutrient levels response to stimulus homeostatic process response to external stimulus adaptive thermogenesis multicellular organismal-level homeostasis response to dietary excess diet induced thermogenesis metabolic process energy homeostasis cellular response to stimulus regulation of localization regulation of cellular process signaling transport regulation of signaling receptor activity monoatomic ion transmembrane transport regulation of AMPA receptor activity positive regulation of biological process regulation of transmembrane transporter activity regulation of signal transduction regulation of monoatomic ion transmembrane transport cell communication regulation of transporter activity positive regulation of molecular function localization positive regulation of monoatomic ion transport positive regulation of transmembrane transport monoatomic ion transport positive regulation of monoatomic ion transmembrane transport signal transduction positive regulation of cellular process regulation of monoatomic ion transmembrane transporter activity regulation of biological process regulation of signaling regulation of transport positive regulation of signaling receptor activity regulation of monoatomic ion transport biological regulation establishment of localization transmembrane transport regulation of molecular function positive regulation of AMPA receptor activity regulation of transmembrane transport positive regulation of transport regulation of response to stimulus positive regulation of transporter activity regulation of neurotransmitter receptor activity positive regulation of ion transmembrane transporter activity regulation of cell communication cellular process response to stress response to abiotic stimulus response to cold response to temperature stimulus regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development regulation of multicellular organismal process developmental process regulation of multicellular organismal development bone mineralization animal organ development tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification regulation of multicellular organism growth regulation of growth regulation of developmental growth negative regulation of multicellular organism growth developmental growth negative regulation of developmental process growth negative regulation of biological process multicellular organism growth negative regulation of developmental growth negative regulation of growth negative regulation of multicellular organismal process adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway positive regulation of cell communication positive regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of intracellular signal transduction regulation of protein kinase A signaling protein kinase A signaling positive regulation of protein kinase A signaling positive regulation of signaling fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process regulation of nitrogen compound metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of protein modification process organic substance metabolic process nitrogen compound metabolic process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process positive regulation of nitrogen compound metabolic process regulation of phosphorylation positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of lyase activity activation of adenylate cyclase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity system process regulation of system process muscle contraction muscle system process regulation of muscle system process negative regulation of muscle contraction smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction negative regulation of smooth muscle contraction regulation of cAMP-dependent protein kinase activity positive regulation of cAMP-dependent protein kinase activity positive regulation of macromolecule biosynthetic process cellular nitrogen compound biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II heterocycle metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular nitrogen compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process aromatic compound biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process RNA biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process heterocycle biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular aromatic compound metabolic process positive regulation of cellular biosynthetic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption transmembrane receptor protein tyrosine kinase signaling pathway cellular component biogenesis cellular component assembly activation of transmembrane receptor protein tyrosine kinase activity activation of protein kinase activity cellular component organization protein-containing complex assembly cellular component organization or biogenesis enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway protein-containing complex organization import into cell receptor-mediated endocytosis endocytosis vesicle-mediated transport cellular localization endosome to lysosome transport intracellular transport lysosomal transport establishment of localization in cell vacuolar transport negative adaptation of signaling pathway negative regulation of signaling desensitization of G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication regulation of protein binding desensitization of G protein-coupled receptor signaling pathway by arrestin negative regulation of cellular process regulation of G protein-coupled receptor signaling pathway negative regulation of response to stimulus negative regulation of binding regulation of binding negative regulation of molecular function negative regulation of signal transduction negative regulation of protein binding adaptation of signaling pathway positive regulation of organelle organization catabolic process regulation of cellular component organization positive regulation of cellular component organization regulation of autophagosome maturation macroautophagy autophagy protein-containing complex disassembly regulation of autophagy regulation of protein-containing complex disassembly cellular catabolic process autophagosome maturation positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of protein-containing complex disassembly cellular component disassembly positive regulation of autophagy regulation of catabolic process positive regulation of autophagosome maturation regulation of organelle organization positive regulation of catabolic process organelle organization regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process lipophagy positive regulation of lipophagy regulation of lipophagy response to psychosocial stress regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade regulation of tube diameter regulation of systemic arterial blood pressure mediated by a chemical signal regulation of blood pressure regulation of tube size norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure negative regulation of blood pressure regulation of systemic arterial blood pressure by norepinephrine-epinephrine regulation of systemic arterial blood pressure circulatory system process negative regulation of systemic arterial blood pressure vascular process in circulatory system regulation of biological quality blood vessel diameter maintenance vasodilation blood circulation regulation of anatomical structure size cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to endogenous stimulus response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound response to peptide cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to peptide cellular response to organic substance response to amyloid-beta regulation of sodium ion transport metal ion transport monoatomic cation transport regulation of metal ion transport sodium ion transport heat generation regulation of postsynaptic membrane potential modulation of chemical synaptic transmission positive regulation of excitatory postsynaptic potential chemical synaptic transmission, postsynaptic synaptic signaling modulation of excitatory postsynaptic potential mini excitatory postsynaptic potential trans-synaptic signaling nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of mini excitatory postsynaptic potential positive regulation of mini excitatory postsynaptic potential regulation of trans-synaptic signaling anterograde trans-synaptic signaling excitatory postsynaptic potential regulation of membrane potential	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle neuronal dense core vesicle bounding membrane of organelle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle membrane protein-containing complex receptor complex Golgi apparatus endosome membrane endosome cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane lytic vacuole vacuole lysosome early endosome nucleus
B	Camelid Antibody Fragment	-	-	-

InterPro Annotation InterPro: Classification of protein families

Chains	Accession	Name	Type
A	IPR000332	Beta 2 adrenoceptor	Family
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR002233	Adrenoceptor family	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Disease Associations: Pharos Pharos: Illuminating the Druggable Genome

Chains	Drug Target	Associated Disease
A	Pharos: P07550	asthma cardiomyopathy dilated cardiomyopathy Ventricular Dysfunction, Left prostate cancer HIV infectious disease nervous system disorder AIDS dementia complex chronic obstructive pulmonary disease potassium deficiency disease lung disease obesity disorder ovarian cancer essential tremor bipolar disorder asthma cardiomyopathy dilated cardiomyopathy Ventricular Dysfunction, Left prostate cancer HIV infectious disease nervous system disorder AIDS dementia complex chronic obstructive pulmonary disease potassium deficiency disease lung disease obesity disorder ovarian cancer essential tremor bipolar disorder peripheral nervous system disease familial hyperlipidemia breast fibroadenoma lung adenocarcinoma glaucoma cardiac arrest hereditary diffuse gastric adenocarcinoma pulmonary emphysema hypertensive disorder inherited susceptibility to asthma dilated cardiomyopathy 1A atrial fibrillation ocular hypertension Parkinson disease breast cancer peripheral neuropathy fibromyalgia vasomotor rhinitis bronchiectasis gastric cancer viral encephalitis lung cancer malignant colon neoplasm seasonal allergic rhinitis hypertrophic cardiomyopathy allergic rhinitis myocardial ischemia non-small cell lung carcinoma dry eye syndrome intrinsic asthma atrioventricular block open-angle glaucoma osteosarcoma B-cell chronic lymphocytic leukemia breast carcinoma bronchitis gastric neoplasm hemangioma malignant ependymoma psoriasis medulloblastoma rhinitis hyperlipidemia allergic asthma monogenic obesity common cold anaphylaxis coronary artery disease atopic conjunctivitis ductal breast carcinoma in situ invasive ductal breast carcinoma autism

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	β₂ adrenergic receptor with a bound positive allosteric modulator

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.