6N48

Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator

Present annotations:

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Product Annotation
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_3	e6n48A2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
A	Phage_lysozyme_2	e6n48A1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	V-set_1	e6n48B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_1	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	Antibody Fab Fragment	VH	Vicugna pacos (alpaca)	IGHV3S5301, IGHJ401	V-DOMAIN VH	IG	VH	IMGT (202307-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	endolysin,beta-2 adrenergic receptor,beta-2 adrenergicreceptor chimera	SAbDab (2023-03-01)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera	binding protein binding adenylate cyclase binding enzyme binding transmembrane signaling receptor activity G protein-coupled receptor activity adrenergic receptor activity beta-adrenergic receptor activity beta2-adrenergic receptor activity G protein-coupled amine receptor activity signaling receptor activity molecular transducer activity identical protein binding ion binding cation binding norepinephrine binding organic cyclic compound binding catecholamine binding potassium channel regulator activity channel regulator activity molecular function regulator activity ion channel regulator activity protein homodimerization activity protein dimerization activity protein-containing complex binding	cellular process cell differentiation developmental process fat cell differentiation cellular developmental process brown fat cell differentiation response to endogenous stimulus response to organic substance response to organonitrogen compound response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to organic substance cellular response to organonitrogen compound cellular response to endogenous stimulus response to peptide cellular response to peptide response to nitrogen compound cellular response to nitrogen compound response to oxygen-containing compound cellular response to oxygen-containing compound response to amyloid-beta cellular response to amyloid-beta multicellular organismal process multicellular organism growth growth regulation of growth regulation of multicellular organism growth negative regulation of multicellular organism growth negative regulation of growth negative regulation of biological process developmental growth regulation of developmental growth negative regulation of developmental growth regulation of biological process regulation of developmental process negative regulation of developmental process regulation of multicellular organismal process negative regulation of multicellular organismal process biological regulation	plasma membrane membrane apical plasma membrane apical part of cell cell periphery plasma membrane region cellular anatomical entity intracellular anatomical structure cytoplasm vesicle membrane coated vesicle clathrin-coated vesicle endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane clathrin-coated vesicle membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane organelle membrane cytoplasmic vesicle vesicle organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle clathrin-coated endocytic vesicle intracellular vesicle bounding membrane of organelle endosome early endosome endomembrane system endosome membrane Golgi apparatus nucleus protein-containing complex receptor complex
B	Camelid Antibody Fragment	none	none	none

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	β₂ adrenergic receptor with a bound positive allosteric modulator

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.