6RXV

Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B2

Present annotations:

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Product Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth UA]	SCOP2B Superfamily	UTPB complex component-like	8056020	3002330	SCOP2B (2022-06-29)
I [auth UL]	SCOP2B Superfamily	UTPB complex component-like	8056019	3002330	SCOP2B (2022-06-29)
J [auth UM]	SCOP2B Superfamily	UTPB complex component-like	8056022	3002330	SCOP2B (2022-06-29)
O [auth UU]	SCOP2B Superfamily	UTPB complex component-like	8056021	3002330	SCOP2B (2022-06-29)
R [auth CA]	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8065682	3000118	SCOP2B (2022-06-29)
S [auth CB]	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8065682	3000118	SCOP2B (2022-06-29)
V [auth CE]	SCOP2B Superfamily	L30e-like	8063954	3001739	SCOP2B (2022-06-29)
W [auth CF]	SCOP2B Superfamily	L30e-like	8063954	3001739	SCOP2B (2022-06-29)
BA [auth CK]	SCOP2B Superfamily	Class II aaRS ABD-related	8095989	3000465	SCOP2B (2022-06-29)
BA [auth CK]	SCOP2B Superfamily	Class II aaRS ABD-related	8095988	3000465	SCOP2B (2022-06-29)
EA [auth CN]	SCOP2B Superfamily	alpha/beta knot	8094639	3001122	SCOP2B (2022-06-29)
FA [auth CO]	SCOP2B Superfamily	alpha/beta knot	8094639	3001122	SCOP2B (2022-06-29)
LA [auth Ca]	SCOP2B Superfamily	Ribosomal S3Ae-like	8094667	3002166	SCOP2B (2022-06-29)
NA [auth Cc]	SCOP2B Superfamily	Ribosomal protein S7	8095683	3000799	SCOP2B (2022-06-29)
TA [auth Ci]	SCOP2 Family	Ribosomal protein L18p and S11	8095756	4000555	SCOP2 (2022-06-29)
TA [auth Ci]	SCOP2 Superfamily	Translational machinery components	8095757	3000571	SCOP2 (2022-06-29)
UA [auth Cj]	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8097794	3000100	SCOP2B (2022-06-29)
WA [auth Cm]	SCOP2 Family	Ribosomal protein S8	8095562	4002027	SCOP2 (2022-06-29)
WA [auth Cm]	SCOP2 Superfamily	Ribosomal protein S8	8095563	3000709	SCOP2 (2022-06-29)
YA [auth Co]	SCOP2B Superfamily	Ribosomal proteins S24e L23 and L15e	8098446	3000210	SCOP2B (2022-06-29)
ZA [auth Cp]	SCOP2B Superfamily	Nucleic acid-binding proteins	8095187	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth UA]	ANAPC4_WD40_6	e6rxvUA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_6	ECOD (1.6)
A [auth UA]	ANAPC4_WD40_4	e6rxvUA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_4	ECOD (1.6)
A [auth UA]	Utp12	e6rxvUA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)	T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13	F: Utp12	ECOD (1.6)
D [auth UD]	ANAPC4_WD40_9	e6rxvUD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_9	ECOD (1.6)
D [auth UD]	ANAPC4_WD40_4	e6rxvUD2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_4	ECOD (1.6)
E [auth UF]	TPR_11_6	e6rxvUF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_6	ECOD (1.6)
J [auth UM]	ANAPC4_WD40_7	e6rxvUM3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_7	ECOD (1.6)
J [auth UM]	ANAPC4_WD40_10	e6rxvUM2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
J [auth UM]	Utp13	e6rxvUM1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)	T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13	F: Utp13	ECOD (1.6)
O [auth UU]	ANAPC4_WD40_9	e6rxvUU3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_9	ECOD (1.6)
O [auth UU]	Utp21	e6rxvUU1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)	T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13	F: Utp21	ECOD (1.6)
Q [auth UZ]	Ribosomal_L1_2nd	e6rxvUZ1	A: a+b two layers	X: a+b domain in Ribosomal protein L1 (From Topology)	H: a+b domain in Ribosomal protein L1 (From Topology)	T: a+b domain in Ribosomal protein L1	F: Ribosomal_L1_2nd	ECOD (1.6)
Q [auth UZ]	Ribosomal_L1_1st_2	e6rxvUZ2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Rossmann-like domain in Ribosomal protein L1 (From Topology)	T: Rossmann-like domain in Ribosomal protein L1	F: Ribosomal_L1_1st_2	ECOD (1.6)
R [auth CA]	Fibrillarin	e6rxvCA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Fibrillarin	ECOD (1.6)
S [auth CB]	Fibrillarin	e6rxvCB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Fibrillarin	ECOD (1.6)
T [auth CC]	Nop_C	e6rxvCC3	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: Nop C-terminal domain	F: Nop_C	ECOD (1.6)
T [auth CC]	Nop_N	e6rxvCC1	A: alpha complex topology	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: Nop_N	ECOD (1.6)
T [auth CC]	NOP5NT	e6rxvCC2	A: mixed a+b and a/b	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: NOP5NT	ECOD (1.6)
V [auth CE]	Ribosomal_L7Ae_1	e6rxvCE1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: Ribosomal_L7Ae_1	ECOD (1.6)
W [auth CF]	Ribosomal_L7Ae_1	e6rxvCF1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: Ribosomal_L7Ae_1	ECOD (1.6)
Y [auth CH]	RTC	e6rxvCH2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: RTC	ECOD (1.6)
Y [auth CH]	RTC_insert	e6rxvCH1	A: a+b three layers	X: Thioredoxin-like	H: RNA 3'-terminal phosphate cyclase, RPTC, insert domain (From Topology)	T: RNA 3'-terminal phosphate cyclase, RPTC, insert domain	F: RTC_insert	ECOD (1.6)
AA [auth CJ]	S4	e6rxvCJ1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Alpha-L RNA-binding motif	F: S4	ECOD (1.6)
EA [auth CN]	EMG1	e6rxvCN1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: EMG1	ECOD (1.6)
FA [auth CO]	EMG1	e6rxvCO1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: EMG1	ECOD (1.6)
HA [auth CQ]	KH_1	e6rxvCQ1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: KH-domains	T: Eukaryotic type KH-domain (KH-domain type I)	F: KH_1	ECOD (1.6)
HA [auth CQ]	KOG3273	e6rxvCQ2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: KH-domains	T: Eukaryotic type KH-domain (KH-domain type I)	F: KOG3273	ECOD (1.6)
IA [auth CR]	tRNA_bind_2	e6rxvCR4	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: tRNA_bind_2	ECOD (1.6)
IA [auth CR]	GNAT_acetyltr_2	e6rxvCR1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: GNAT_acetyltr_2	ECOD (1.6)
IA [auth CR]	DUF1726	e6rxvCR2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DUF1726	ECOD (1.6)
IA [auth CR]	Helicase_RecD	e6rxvCR3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_RecD	ECOD (1.6)
JA [auth CS]	tRNA_bind_2	e6rxvCS4	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: tRNA_bind_2	ECOD (1.6)
JA [auth CS]	GNAT_acetyltr_2	e6rxvCS1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: GNAT_acetyltr_2	ECOD (1.6)
JA [auth CS]	DUF1726	e6rxvCS2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DUF1726	ECOD (1.6)
JA [auth CS]	Helicase_RecD	e6rxvCS3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_RecD	ECOD (1.6)
LA [auth Ca]	Ribosomal_S3Ae_N	e6rxvCa2	A: beta barrels	X: Ribosomal protein L25-like	H: 40S ribosomal protein S3A N-terminal domain (From Topology)	T: 40S ribosomal protein S3A N-terminal domain	F: Ribosomal_S3Ae_N	ECOD (1.6)
LA [auth Ca]	Ribosomal_S3Ae_C	e6rxvCa1	A: a+b two layers	X: T-fold	H: 40S ribosomal protein S3A C-terminal domain (From Topology)	T: 40S ribosomal protein S3A C-terminal domain	F: Ribosomal_S3Ae_C	ECOD (1.6)
MA [auth Cb]	Ribosomal_S4e	e6rxvCb1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosomal_S4e	ECOD (1.6)
MA [auth Cb]	40S_S4_C	e6rxvCb2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: 40S_S4_C	ECOD (1.6)
MA [auth Cb]	RS4NT	e6rxvCb3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Alpha-L RNA-binding motif	F: RS4NT	ECOD (1.6)
NA [auth Cc]	Ribosomal_S7_1	e6rxvCc1	A: alpha arrays	X: Ribosomal protein S7 (From Topology)	H: Ribosomal protein S7 (From Topology)	T: Ribosomal protein S7	F: Ribosomal_S7_1	ECOD (1.6)
OA [auth Cd]	Ribosomal_S6e	e6rxvCd1	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: Ribosomal_S6e	ECOD (1.6)
PA [auth Ce]	Ribosomal_S7e_C	e6rxvCe1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: 40S ribosomal protein S7-A (From Topology)	T: 40S ribosomal protein S7-A	F: Ribosomal_S7e_C	ECOD (1.6)
PA [auth Ce]	Ribosomal_S7e_N	e6rxvCe2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: 40S ribosomal protein S7-A (From Topology)	T: 40S ribosomal protein S7-A	F: Ribosomal_S7e_N	ECOD (1.6)
QA [auth Cf]	Ribosomal_S8e	e6rxvCf1	A: beta barrels	X: Ribosomal protein L14-like	H: Ribosomal protein L14-related (From Topology)	T: Ribosomal protein L14-related	F: Ribosomal_S8e	ECOD (1.6)
RA [auth Cg]	S4	e6rxvCg1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Alpha-L RNA-binding motif	F: S4	ECOD (1.6)
SA [auth Ch]	Ribosomal_S15_2	e6rxvCh1	A: alpha arrays	X: S15/NS1 RNA-binding domain (From Topology)	H: S15/NS1 RNA-binding domain (From Topology)	T: S15/NS1 RNA-binding domain	F: Ribosomal_S15_2	ECOD (1.6)
TA [auth Ci]	Ribosomal_S11	e6rxvCi1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ribosomal_S11	ECOD (1.6)
UA [auth Cj]	Ribosomal_S9	e6rxvCj1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: Ribosomal_S9	ECOD (1.6)
VA [auth Ck]	Ribosomal_S17_1	e6rxvCk1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosomal_S17_1	ECOD (1.6)
WA [auth Cm]	Ribosomal_S8_N_1	e6rxvCm1	A: a+b two layers	X: R3H domain-like	H: Ribosomal protein S8, N-terminal domain (From Topology)	T: Ribosomal protein S8, N-terminal domain	F: Ribosomal_S8_N_1	ECOD (1.6)
WA [auth Cm]	Ribosomal_S8_C_1	e6rxvCm2	A: a+b two layers	X: Ribosomal protein S8, C-terminal domain (From Topology)	H: Ribosomal protein S8, C-terminal domain (From Topology)	T: Ribosomal protein S8, C-terminal domain	F: Ribosomal_S8_C_1	ECOD (1.6)
XA [auth Cn]	Ribosom_S12_S23	e6rxvCn1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosom_S12_S23	ECOD (1.6)
YA [auth Co]	Ribosomal_S24e	e6rxvCo1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal proteins S24e, L23 and L15e (From Topology)	T: Ribosomal proteins S24e, L23 and L15e	F: Ribosomal_S24e	ECOD (1.6)
ZA [auth Cp]	Ribosomal_S28e	e6rxvCp1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: Ribosomal_S28e	ECOD (1.6)
DB [auth UV]	Nrap_D2	e6rxvUV5	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: PAP/OAS1 substrate-binding domain	F: Nrap_D2	ECOD (1.6)
DB [auth UV]	Nrap_D5	e6rxvUV6	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: PAP/OAS1 substrate-binding domain	F: Nrap_D5	ECOD (1.6)
DB [auth UV]	Nrap_D3	e6rxvUV1	A: a+b two layers	X: Alpha-beta plaits	H: PAP/Archaeal CCA-adding enzyme, C-terminal domain (From Topology)	T: PAP/Archaeal CCA-adding enzyme, C-terminal domain	F: Nrap_D3	ECOD (1.6)
DB [auth UV]	UNK_F_TYPE	e6rxvUV2	A: a+b two layers	X: Alpha-beta plaits	H: PAP/Archaeal CCA-adding enzyme, C-terminal domain (From Topology)	T: PAP/Archaeal CCA-adding enzyme, C-terminal domain	F: UNK_F_TYPE	ECOD (1.6)
DB [auth UV]	Nrap	e6rxvUV4	A: a+b three layers	X: Nucleotidyltransferase-like	H: Nucleotidyltransferase (From Topology)	T: Nucleotidyltransferase	F: Nrap	ECOD (1.6)
DB [auth UV]	Nrap_D4	e6rxvUV3	A: a+b three layers	X: Nucleotidyltransferase-like	H: Nucleotidyltransferase (From Topology)	T: Nucleotidyltransferase	F: Nrap_D4	ECOD (1.6)
EB [auth CV]	KOG4008,Peripla_BP_4_C	e6rxvCV1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: KOG4008,Peripla_BP_4_C	ECOD (1.6)
FB [auth CW]	ANAPC4_WD40_5	e6rxvCW1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_5	ECOD (1.6)
IB [auth UE]	UNK_F_TYPE	e6rxvUE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)	T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13	F: UNK_F_TYPE	ECOD (1.6)
OB [auth UI]	UNK_F_TYPE	e6rxvUI1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)	T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13	F: UNK_F_TYPE	ECOD (1.6)
KB [auth Cl]	Ribosomal_S13	e6rxvCl1	A: alpha arrays	X: HhH/H2TH	H: H2TH (From Topology)	T: H2TH	F: Ribosomal_S13	ECOD (1.6)
LB [auth CX]	Bystin	e6rxvCX1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Bystin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A [auth UA]	PF04003	Dip2/Utp12 Family (Utp12)	Dip2/Utp12 Family	-	Family
A [auth UA]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
B [auth UB]	PF04147	Nop14-like family (Nop14)	Nop14-like family	-	Family
C [auth UC]	PF09368	Sas10 C-terminal domain (Sas10)	Sas10 C-terminal domain	Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.	Domain
D [auth UD]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
E [auth UF]	PF08640	U3 small nucleolar RNA-associated protein 6 (U3_assoc_6)	U3 small nucleolar RNA-associated protein 6	-	Family
F [auth UG]	PF08149	BING4CT (NUC141) domain (BING4CT)	BING4CT (NUC141) domain	This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins [1].	Domain
G [auth UJ]	PF08146	BP28CT (NUC211) domain (BP28CT)	BP28CT (NUC211) domain	This C terminal domain is found in BAP28-like nucleolar proteins [1].	Domain
G [auth UJ]	PF12397	U3 small nucleolar RNA-associated protein 10 (U3snoRNP10)	U3 small nucleolar RNA-associated protein 10	-	Family
H [auth UK]	PF03998	Utp11 protein (Utp11)	Utp11 protein	-	Family
I [auth UL]	PF04003	Dip2/Utp12 Family (Utp12)	Dip2/Utp12 Family	-	Family
I [auth UL]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
J [auth UM]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
J [auth UM]	PF08625	Utp13 specific WD40 associated domain (Utp13)	Utp13 specific WD40 associated domain	Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable o ...	Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end [1].	Domain
K [auth UN]	PF04615	Utp14 protein (Utp14)	Utp14 protein	-	Family
L [auth UO]	PF09384	UTP15 C terminal (UTP15_C)	UTP15 C terminal	-	Family
L [auth UO]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
M [auth UQ]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
O [auth UU]	PF04192	Utp21 specific WD40 associated putative domain (Utp21)	Utp21 specific WD40 associated putative domain	Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.	Domain
O [auth UU]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
Q [auth UZ]	PF00687	Ribosomal protein L1p/L10e family (Ribosomal_L1)	Ribosomal protein L1p/L10e family	This family includes prokaryotic L1 and eukaryotic L10.	Domain
R [auth CA], S [auth CB]	PF01269	Fibrillarin (Fibrillarin)	Fibrillarin	-	Domain
T [auth CC]	PF08156	NOP5NT (NUC127) domain (NOP5NT)	NOP5NT (NUC127) domain	This N terminal domain is found in RNA-binding proteins of the NOP5 family [1].	Domain
T [auth CC]	PF01798	snoRNA binding domain, fibrillarin (Nop)	snoRNA binding domain, fibrillarin	-	Family
U [auth CD]	PF08156	NOP5NT (NUC127) domain (NOP5NT)	NOP5NT (NUC127) domain	This N terminal domain is found in RNA-binding proteins of the NOP5 family [1].	Domain
U [auth CD]	PF01798	snoRNA binding domain, fibrillarin (Nop)	snoRNA binding domain, fibrillarin	-	Family
V [auth CE], W [auth CF]	PF01248	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	Domain
X [auth CG]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
Y [auth CH]	PF05189	RNA 3'-terminal phosphate cyclase (RTC), insert domain (RTC_insert)	RNA 3'-terminal phosphate cyclase (RTC), insert domain	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation o ...	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].	Domain
Y [auth CH]	PF01137	RNA 3'-terminal phosphate cyclase (RTC)	RNA 3'-terminal phosphate cyclase	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation o ...	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].	Domain
Z [auth CI]	PF08142	AARP2CN (NUC121) domain (AARP2CN)	AARP2CN (NUC121) domain	This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU [1].	Domain
Z [auth CI]	PF04950	40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal (RIBIOP_C)	40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal	-	Family
AA [auth CJ]	PF00163	Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)	Ribosomal protein S4/S9 N-terminal domain	-	Family
AA [auth CJ]	PF01479	S4 domain (S4)	S4 domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.	Domain
BA [auth CK]	PF04427	Brix domain (Brix)	Brix domain	-	Domain
CA [auth CL]	PF04006	Mpp10 protein (Mpp10)	Mpp10 protein	-	Family
DA [auth CM]	PF04158	Sof1-like domain (Sof1)	Sof1-like domain	-	Family
DA [auth CM]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
EA [auth CN], FA [auth CO]	PF03587	EMG1/NEP1 methyltransferase (EMG1)	EMG1/NEP1 methyltransferase	-	Family
GA [auth CP]	PF17903	Krr1 KH1 domain (KH_8)	Krr1 KH1 domain	This entry represents the first KH domain in the KRR1 protein [1]. Krr1 is a ribosomal assembly factor. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif and is involved in binding another assembly factor, Kri1 [1].	Domain
IA [auth CR], JA [auth CS]	PF13725	Possible tRNA binding domain (tRNA_bind_2)	Possible tRNA binding domain	-	Family
IA [auth CR], JA [auth CS]	PF08351	tRNA(Met) cytidine acetyltransferase TmcA, N-terminal (TmcA_N)	tRNA(Met) cytidine acetyltransferase TmcA, N-terminal	-	Family
IA [auth CR], JA [auth CS]	PF13718	GNAT acetyltransferase 2 (GNAT_acetyltr_2)	GNAT acetyltransferase 2	-	Family
IA [auth CR], JA [auth CS]	PF05127	Helicase (Helicase_RecD)	Helicase	This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble ...	This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [1]. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [2].	Domain
KA [auth CT]	PF08698	Fcf2 pre-rRNA processing (Fcf2)	Fcf2 pre-rRNA processing	-	Family
LA [auth Ca]	PF01015	Ribosomal S3Ae family (Ribosomal_S3Ae)	Ribosomal S3Ae family	-	Family
MA [auth Cb]	PF00900	Ribosomal family S4e (Ribosomal_S4e)	Ribosomal family S4e	-	Family
MA [auth Cb]	PF16121	40S ribosomal protein S4 C-terminus (40S_S4_C)	40S ribosomal protein S4 C-terminus	-	Family
MA [auth Cb]	PF08071	RS4NT (NUC023) domain (RS4NT)	RS4NT (NUC023) domain	This is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains [1].	Domain
MA [auth Cb]	PF01479	S4 domain (S4)	S4 domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.	Domain
NA [auth Cc]	PF00177	Ribosomal protein S7p/S5e (Ribosomal_S7)	Ribosomal protein S7p/S5e	This family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.	Domain
OA [auth Cd]	PF01092	Ribosomal protein S6e (Ribosomal_S6e)	Ribosomal protein S6e	-	Family
PA [auth Ce]	PF01251	Ribosomal protein S7e (Ribosomal_S7e)	Ribosomal protein S7e	-	Family
QA [auth Cf]	PF01201	Ribosomal protein S8e (Ribosomal_S8e)	Ribosomal protein S8e	-	Family
RA [auth Cg]	PF00163	Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)	Ribosomal protein S4/S9 N-terminal domain	-	Family
RA [auth Cg]	PF01479	S4 domain (S4)	S4 domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.	Domain
SA [auth Ch]	PF00312	Ribosomal protein S15 (Ribosomal_S15)	Ribosomal protein S15	-	Domain
TA [auth Ci]	PF00411	Ribosomal protein S11 (Ribosomal_S11)	Ribosomal protein S11	-	Family
UA [auth Cj]	PF00380	Ribosomal protein S9/S16 (Ribosomal_S9)	Ribosomal protein S9/S16	-	Family
VA [auth Ck]	PF16205	Ribosomal_S17 N-terminal (Ribosomal_S17_N)	Ribosomal_S17 N-terminal	-	Family
VA [auth Ck]	PF00366	Ribosomal protein S17 (Ribosomal_S17)	Ribosomal protein S17	-	Domain
WA [auth Cm]	PF00410	Ribosomal protein S8 (Ribosomal_S8)	Ribosomal protein S8	-	Domain
XA [auth Cn]	PF00164	Ribosomal protein S12/S23 (Ribosom_S12_S23)	Ribosomal protein S12/S23	-	Family
YA [auth Co]	PF01282	Ribosomal protein S24e (Ribosomal_S24e)	Ribosomal protein S24e	-	Family
ZA [auth Cp]	PF01200	Ribosomal protein S28e (Ribosomal_S28e)	Ribosomal protein S28e	-	Family
AB [auth CU]	PF15375	Domain of unknown function (DUF4602) (DUF4602)	Domain of unknown function (DUF4602)	-	Family
DB [auth UV]	PF03813	Nrap protein domain 1 (Nrap)	Nrap protein domain 1	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1]. This domain has a nucleotidyltransferase structure.	Domain
DB [auth UV]	PF17403	Nrap protein PAP/OAS-like domain (Nrap_D2)	Nrap protein PAP/OAS-like domain	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].	Domain
DB [auth UV]	PF17406	Nrap protein PAP/OAS1-like domain 5 (Nrap_D5)	Nrap protein PAP/OAS1-like domain 5	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].	Domain
DB [auth UV]	PF17407	Nrap protein domain 6 (Nrap_D6)	Nrap protein domain 6	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].	Domain
DB [auth UV]	PF17404	Nrap protein domain 3 (Nrap_D3)	Nrap protein domain 3	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].	Domain
DB [auth UV]	PF17405	Nrap protein nucleotidyltransferase domain 4 (Nrap_D4)	Nrap protein nucleotidyltransferase domain 4	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].	Domain
EB [auth CV]	PF17799	Rrp7 RRM-like N-terminal domain (RRM_Rrp7)	Rrp7 RRM-like N-terminal domain	This domain corresponds to the N-terminal RNA-binding domain found in the Rrp7 protein. It has an RRM-like fold with a circular permutation [1].	Domain
EB [auth CV]	PF12923	Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain (RRP7)	Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain	RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly [1]. It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle [1-2].	Domain
GB [auth UT]	PF20416	Domain of unknown function (DUF6700) (DUF6700)	Domain of unknown function (DUF6700)	This putative domain is found in the UTP20 protein which associated with the U3 snRNA.	Domain
GB [auth UT]	PF07539	Down-regulated in metastasis (DRIM)	Down-regulated in metastasis	-	Family
IB [auth UE], OB [auth UI]	PF04003	Dip2/Utp12 Family (Utp12)	Dip2/Utp12 Family	-	Family
JB [auth US]	PF03914	CBF/Mak21 family (CBF)	CBF/Mak21 family	-	Family
KB [auth Cl]	PF00416	Ribosomal protein S13/S18 (Ribosomal_S13)	Ribosomal protein S13/S18	-	Family
LB [auth CX]	PF05291	Bystin (Bystin)	Bystin	-	Family
NB [auth CZ]	PF08164	Apoptosis-antagonizing transcription factor, C-terminal (TRAUB)	Apoptosis-antagonizing transcription factor, C-terminal	This C terminal domain is found in traube proteins [1]. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcripti ...	This C terminal domain is found in traube proteins [1]. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.	Domain
PB [auth UP]	PF08297	U3 snoRNA associated (U3_snoRNA_assoc)	U3 snoRNA associated	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth UA]	Periodic tryptophan protein 2-like protein			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
B [auth UB]	Utp2		cellular process ribonucleoprotein complex biogenesis ribosome biogenesis cellular component biogenesis cellular component organization or biogenesis	intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome protein-containing complex ribonucleoprotein complex
C [auth UC]	Utp3
D [auth UD]	Utp4			preribosome 90S preribosome protein-containing complex ribonucleoprotein complex
E [auth UF]	Utp6	nucleic acid binding RNA binding binding snoRNA binding organic cyclic compound binding heterocyclic compound binding		intracellular anatomical structure nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle cellular anatomical entity
F [auth UG]	Utp7			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
G [auth UJ]	UTP10			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
H [auth UK]	U3 small nucleolar RNA-associated protein 11			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome protein-containing complex ribonucleoprotein complex
I [auth UL]	Utp12			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
J [auth UM]	Utp13			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome protein-containing complex ribonucleoprotein complex
K [auth UN]	Utp14			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome protein-containing complex ribonucleoprotein complex
L [auth UO]	Utp15			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
M [auth UQ]	Utp17
N [auth UR]	Utp18			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
O [auth UU]	Utp21			preribosome small-subunit processome protein-containing complex ribonucleoprotein complex
P [auth UX]	Utp24	none	none	none
Q [auth UZ]	Utp30			protein-containing complex ribonucleoprotein complex
R [auth CA], S [auth CB]	Nop1	catalytic activity methyltransferase activity transferase activity transferase activity, transferring one-carbon groups nucleic acid binding RNA binding binding organic cyclic compound binding heterocyclic compound binding	metabolic process methylation
T [auth CC]	Nop56	nucleic acid binding RNA binding binding snoRNA binding organic cyclic compound binding heterocyclic compound binding		sno(s)RNA-containing ribonucleoprotein complex box C/D RNP complex protein-containing complex ribonucleoprotein complex intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome
U [auth CD]	Nop58	nucleic acid binding RNA binding binding snoRNA binding organic cyclic compound binding heterocyclic compound binding snRNA binding		sno(s)RNA-containing ribonucleoprotein complex box C/D RNP complex protein-containing complex ribonucleoprotein complex intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome
V [auth CE], W [auth CF]	Snu13	nucleic acid binding RNA binding binding organic cyclic compound binding heterocyclic compound binding		intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity protein-containing complex ribonucleoprotein complex
X [auth CG]	Rrp9	nucleic acid binding RNA binding binding snoRNA binding U3 snoRNA binding organic cyclic compound binding heterocyclic compound binding
Y [auth CH]	RNA 3'-terminal phosphate cyclase-like protein	catalytic activity	cellular process ribonucleoprotein complex biogenesis ribosome biogenesis cellular component biogenesis cellular component organization or biogenesis	intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
Z [auth CI]	Bms1	catalytic activity GTPase activity pyrophosphatase activity hydrolase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ribonucleoside triphosphate phosphatase activity nucleic acid binding RNA binding binding snoRNA binding U3 snoRNA binding organic cyclic compound binding heterocyclic compound binding		preribosome 90S preribosome protein-containing complex ribonucleoprotein complex intracellular anatomical structure cytoplasm cellular anatomical entity nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen small-subunit processome
AA [auth CJ]	Imp3	nucleic acid binding RNA binding binding rRNA binding organic cyclic compound binding heterocyclic compound binding
BA [auth CK]	Imp4	nucleic acid binding RNA binding binding rRNA binding rRNA primary transcript binding organic cyclic compound binding heterocyclic compound binding
CA [auth CL]	Mpp10			intracellular anatomical structure nucleus nucleolus preribosome 90S preribosome membrane-enclosed lumen nuclear lumen protein-containing complex Mpp10 complex organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity nuclear protein-containing complex ribonucleoprotein complex sno(s)RNA-containing ribonucleoprotein complex
DA [auth CM]	Sof1			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome protein-containing complex ribonucleoprotein complex
EA [auth CN], FA [auth CO]	Emg1	binding protein binding identical protein binding catalytic activity methyltransferase activity RNA methyltransferase activity rRNA methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity transferase activity transferase activity, transferring one-carbon groups rRNA (pseudouridine) methyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a rRNA catalytic activity, acting on a nucleic acid nucleic acid binding RNA binding rRNA binding organic cyclic compound binding heterocyclic compound binding		preribosome 90S preribosome protein-containing complex ribonucleoprotein complex intracellular anatomical structure cytoplasm cellular anatomical entity nucleus cytoskeleton microtubule nuclear microtubule microtubule cytoskeleton organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle supramolecular complex supramolecular polymer supramolecular fiber polymeric cytoskeletal fiber membrane-enclosed lumen nuclear lumen nuclear periphery organelle lumen intracellular organelle lumen nucleolus small-subunit processome
GA [auth CP]	KRR1 small subunit processome component	nucleic acid binding RNA binding binding organic cyclic compound binding heterocyclic compound binding		intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome preribosome, small subunit precursor protein-containing complex ribonucleoprotein complex small-subunit processome
HA [auth CQ]	Pre-rRNA-processing protein PNO1	nucleic acid binding RNA binding binding organic cyclic compound binding heterocyclic compound binding	cellular process ribonucleoprotein complex biogenesis ribosome biogenesis cellular component biogenesis cellular component organization or biogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen
IA [auth CR], JA [auth CS]	Kre33	catalytic activity N-acetyltransferase activity acetyltransferase activity N-acyltransferase activity transferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups rRNA cytidine N-acetyltransferase activity nucleic acid binding RNA binding binding snoRNA binding organic cyclic compound binding heterocyclic compound binding	cellular process ribonucleoprotein complex biogenesis ribosome biogenesis ribosomal small subunit biogenesis cellular component biogenesis cellular component organization or biogenesis	intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome preribosome, small subunit precursor protein-containing complex ribonucleoprotein complex small-subunit processome
KA [auth CT]	Fcf2			intracellular anatomical structure nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle cellular anatomical entity
LA [auth Ca]	40S ribosomal protein S1	structural constituent of ribosome structural molecule activity		intracellular anatomical structure cytoplasm cytosol ribosome small ribosomal subunit cytosolic ribosome cytosolic small ribosomal subunit protein-containing complex organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle ribosomal subunit cellular anatomical entity ribonucleoprotein complex
MA [auth Cb]	40S ribosomal protein S4	nucleic acid binding RNA binding binding rRNA binding organic cyclic compound binding heterocyclic compound binding structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
NA [auth Cc]	40S ribosomal protein s5-like protein	nucleic acid binding RNA binding binding organic cyclic compound binding heterocyclic compound binding structural constituent of ribosome structural molecule activity		intracellular anatomical structure cytoplasm cytosol ribosome small ribosomal subunit cytosolic ribosome cytosolic small ribosomal subunit protein-containing complex organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle ribosomal subunit cellular anatomical entity ribonucleoprotein complex
OA [auth Cd]	40S ribosomal protein S6	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
PA [auth Ce]	40S ribosomal protein S7	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
QA [auth Cf]	40S ribosomal protein S8	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
RA [auth Cg]	40S ribosomal protein s9-like protein	nucleic acid binding RNA binding binding rRNA binding organic cyclic compound binding heterocyclic compound binding structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome small ribosomal subunit protein-containing complex organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle ribosomal subunit cellular anatomical entity ribonucleoprotein complex
SA [auth Ch]	40S ribosomal protein S13-like protein	nucleic acid binding RNA binding binding rRNA binding small ribosomal subunit rRNA binding organic cyclic compound binding heterocyclic compound binding structural constituent of ribosome structural molecule activity		intracellular anatomical structure cytoplasm cytosol ribosome small ribosomal subunit cytosolic ribosome cytosolic small ribosomal subunit protein-containing complex organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle ribosomal subunit cellular anatomical entity ribonucleoprotein complex
TA [auth Ci]	40S ribosomal protein S14-like protein	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
UA [auth Cj]	40S ribosomal protein S16-like protein	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
VA [auth Ck]	40S ribosomal protein S11-like protein	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
WA [auth Cm]	40S ribosomal protein S22-like protein	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
XA [auth Cn]	40S ribosomal protein s23-like protein	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome small ribosomal subunit protein-containing complex organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle ribosomal subunit cellular anatomical entity ribonucleoprotein complex
YA [auth Co]	40S ribosomal protein S24	catalytic activity methyltransferase activity transferase activity transferase activity, transferring one-carbon groups structural constituent of ribosome structural molecule activity	metabolic process methylation	intracellular anatomical structure cytoplasm cellular anatomical entity ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle
ZA [auth Cp]	40S ribosomal protein S28-like protein	structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
AB [auth CU]	Faf1
BB [auth C1]	35S ribosomal RNA	none	none	none
CB [auth C2]	U3 snoRNA	none	none	none
DB [auth UV]	U3 small nucleolar RNA-associated protein 22	nucleic acid binding RNA binding binding organic cyclic compound binding heterocyclic compound binding		intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity
EB [auth CV]	Rrp7
FB [auth CW]	Ribosome biogenesis protein ENP2			intracellular anatomical structure nucleus nucleolus membrane-enclosed lumen nuclear lumen organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen intracellular organelle lumen cellular anatomical entity preribosome small-subunit processome protein-containing complex ribonucleoprotein complex
GB [auth UT]	Utp20
HB [auth UH]	Utp8			intracellular anatomical structure nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle cellular anatomical entity
IB [auth UE], OB [auth UI]	Utp5
JB [auth US]	Noc4		cellular process ribonucleoprotein complex biogenesis ribosome biogenesis cellular component biogenesis cellular component organization or biogenesis	intracellular anatomical structure nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle cellular anatomical entity
KB [auth Cl]	Rps18	nucleic acid binding RNA binding binding organic cyclic compound binding heterocyclic compound binding structural constituent of ribosome structural molecule activity		intracellular anatomical structure ribosome organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle cellular anatomical entity
LB [auth CX]	Enp1			intracellular anatomical structure organelle intracellular organelle cellular anatomical entity
MB [auth CY]	U3 small nucleolar ribonucleoprotein protein lcp5-like protein
NB [auth CZ]	Bfr2			intracellular anatomical structure nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle cellular anatomical entity
PB [auth UP]	Utp16	nucleic acid binding RNA binding binding snoRNA binding organic cyclic compound binding heterocyclic compound binding