Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth UA]SCOP2B SuperfamilyUTPB complex component-like8056020 3002330 SCOP2B (2022-02-25)
J [auth UM]SCOP2B SuperfamilyUTPB complex component-like8056022 3002330 SCOP2B (2022-02-25)
O [auth UU]SCOP2B SuperfamilyUTPB complex component-like8056021 3002330 SCOP2B (2022-02-25)
R [auth CA]SCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases8065682 3000118 SCOP2B (2022-02-25)
S [auth CB]SCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases8065682 3000118 SCOP2B (2022-02-25)
V [auth CE]SCOP2B SuperfamilyL30e-like8063954 3001739 SCOP2B (2022-02-25)
W [auth CF]SCOP2B SuperfamilyL30e-like8063954 3001739 SCOP2B (2022-02-25)
BA [auth CK]SCOP2B SuperfamilyClass II aaRS ABD-related8095989 3000465 SCOP2B (2022-02-25)
BA [auth CK]SCOP2B SuperfamilyClass II aaRS ABD-related8095988 3000465 SCOP2B (2022-02-25)
EA [auth CN]SCOP2B Superfamilyalpha/beta knot8094639 3001122 SCOP2B (2022-02-25)
FA [auth CO]SCOP2B Superfamilyalpha/beta knot8094639 3001122 SCOP2B (2022-02-25)
LA [auth Cc]SCOP2B SuperfamilyRibosomal protein S78095683 3000799 SCOP2B (2022-02-25)
PA [auth Ci]SCOP2B SuperfamilyTranslational machinery components8095757 3000571 SCOP2B (2022-02-25)
QA [auth Cj]SCOP2B SuperfamilyRibosomal protein S5 domain 2-like8097794 3000100 SCOP2B (2022-02-25)
RA [auth Cm]SCOP2B SuperfamilyRibosomal protein S88095563 3000709 SCOP2B (2022-02-25)
TA [auth Cp]SCOP2B SuperfamilyNucleic acid-binding proteins8095187 3000135 SCOP2B (2022-02-25)
I [auth UL]SCOP2B SuperfamilyUTPB complex component-like8056019 3002330 SCOP2B (2022-02-25)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth UA]ANAPC4_WD40_6e6rxyUA3 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_6ECOD (1.6)
A [auth UA]ANAPC4_WD40_4e6rxyUA2 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_4ECOD (1.6)
A [auth UA]Utp12e6rxyUA1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: Utp12ECOD (1.6)
J [auth UM]ANAPC4_WD40_7e6rxyUM2 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_7ECOD (1.6)
J [auth UM]ANAPC4_WD40_9e6rxyUM3 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_9ECOD (1.6)
J [auth UM]Utp13e6rxyUM1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: Utp13ECOD (1.6)
M [auth UQ]ANAPC4_WD40_1e6rxyUQ1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 8-bladedF: ANAPC4_WD40_1ECOD (1.6)
O [auth UU]ANAPC4_WD40_9e6rxyUU1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_9ECOD (1.6)
O [auth UU]Utp21e6rxyUU3 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: Utp21ECOD (1.6)
Q [auth UZ]Ribosomal_L1_2nde6rxyUZ2 A: a+b two layersX: a+b domain in Ribosomal protein L1 (From Topology)H: a+b domain in Ribosomal protein L1 (From Topology)T: a+b domain in Ribosomal protein L1F: Ribosomal_L1_2ndECOD (1.6)
Q [auth UZ]Ribosomal_L1_1st_2e6rxyUZ3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Rossmann-like domain in Ribosomal protein L1 (From Topology)T: Rossmann-like domain in Ribosomal protein L1F: Ribosomal_L1_1st_2ECOD (1.6)
R [auth CA]Fibrillarine6rxyCA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: FibrillarinECOD (1.6)
S [auth CB]Fibrillarine6rxyCB1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: FibrillarinECOD (1.6)
T [auth CC]Nop_Ce6rxyCC1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: Nop C-terminal domainF: Nop_CECOD (1.6)
T [auth CC]Nop_Ne6rxyCC3 A: alpha complex topologyX: Nop N-terminal domain (From Topology)H: Nop N-terminal domain (From Topology)T: Nop N-terminal domainF: Nop_NECOD (1.6)
T [auth CC]NOP5NTe6rxyCC2 A: mixed a+b and a/bX: Nop N-terminal domain (From Topology)H: Nop N-terminal domain (From Topology)T: Nop N-terminal domainF: NOP5NTECOD (1.6)
V [auth CE]Ribosomal_L7Ae_1e6rxyCE1 A: a+b three layersX: Bacillus chorismate mutase-likeH: L30e-like (From Topology)T: L30e-likeF: Ribosomal_L7Ae_1ECOD (1.6)
W [auth CF]Ribosomal_L7Ae_1e6rxyCF1 A: a+b three layersX: Bacillus chorismate mutase-likeH: L30e-like (From Topology)T: L30e-likeF: Ribosomal_L7Ae_1ECOD (1.6)
X [auth CG]ANAPC4_WD40_6e6rxyCG1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_6ECOD (1.6)
Y [auth CH]RTCe6rxyCH2 A: a+b two layersX: IF3-likeH: EPT/RTPC-like (From Topology)T: EPT/RTPC-likeF: RTCECOD (1.6)
Y [auth CH]RTC_inserte6rxyCH1 A: a+b three layersX: Thioredoxin-likeH: RNA 3'-terminal phosphate cyclase, RPTC, insert domain (From Topology)T: RNA 3'-terminal phosphate cyclase, RPTC, insert domainF: RTC_insertECOD (1.6)
AA [auth CJ]S4e6rxyCJ1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Alpha-L RNA-binding motifF: S4ECOD (1.6)
EA [auth CN]EMG1e6rxyCN1 A: a/b three-layered sandwichesX: alpha/beta knot (From Topology)H: alpha/beta knot (From Topology)T: alpha/beta knotF: EMG1ECOD (1.6)
FA [auth CO]EMG1e6rxyCO1 A: a/b three-layered sandwichesX: alpha/beta knot (From Topology)H: alpha/beta knot (From Topology)T: alpha/beta knotF: EMG1ECOD (1.6)
GA [auth CP]KOG3273e6rxyCP2 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: KOG3273ECOD (1.6)
GA [auth CP]KOG2874e6rxyCP1 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: KOG2874ECOD (1.6)
HA [auth CQ]KH_1e6rxyCQ1 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: KH_1ECOD (1.6)
HA [auth CQ]KOG3273e6rxyCQ2 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: KH-domainsT: Eukaryotic type KH-domain (KH-domain type I)F: KOG3273ECOD (1.6)
IA [auth CR]tRNA_bind_2e6rxyCR4 A: alpha arraysX: HTHH: HTHT: tri-helicalF: tRNA_bind_2ECOD (1.6)
IA [auth CR]GNAT_acetyltr_2e6rxyCR1 A: a+b three layersX: Nat/IvyH: Acyl-CoA N-acyltransferases (Nat) (From Topology)T: Acyl-CoA N-acyltransferases (Nat)F: GNAT_acetyltr_2ECOD (1.6)
IA [auth CR]DUF1726e6rxyCR2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: DUF1726ECOD (1.6)
IA [auth CR]Helicase_RecDe6rxyCR3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Helicase_RecDECOD (1.6)
JA [auth CS]tRNA_bind_2e6rxyCS4 A: alpha arraysX: HTHH: HTHT: tri-helicalF: tRNA_bind_2ECOD (1.6)
JA [auth CS]GNAT_acetyltr_2e6rxyCS1 A: a+b three layersX: Nat/IvyH: Acyl-CoA N-acyltransferases (Nat) (From Topology)T: Acyl-CoA N-acyltransferases (Nat)F: GNAT_acetyltr_2ECOD (1.6)
JA [auth CS]DUF1726e6rxyCS2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: DUF1726ECOD (1.6)
JA [auth CS]Helicase_RecDe6rxyCS3 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Helicase_RecDECOD (1.6)
LA [auth Cc]Ribosomal_S7_1e6rxyCc1 A: alpha arraysX: Ribosomal protein S7 (From Topology)H: Ribosomal protein S7 (From Topology)T: Ribosomal protein S7F: Ribosomal_S7_1ECOD (1.6)
MA [auth Ce]Ribosomal_S7e_Ce6rxyCe2 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: 40S ribosomal protein S7-A (From Topology)T: 40S ribosomal protein S7-AF: Ribosomal_S7e_CECOD (1.6)
MA [auth Ce]Ribosomal_S7e_Ne6rxyCe1 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: 40S ribosomal protein S7-A (From Topology)T: 40S ribosomal protein S7-AF: Ribosomal_S7e_NECOD (1.6)
NA [auth Cg]S4e6rxyCg1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Alpha-L RNA-binding motifF: S4ECOD (1.6)
OA [auth Ch]Ribosomal_S15_2e6rxyCh1 A: alpha arraysX: S15/NS1 RNA-binding domain (From Topology)H: S15/NS1 RNA-binding domain (From Topology)T: S15/NS1 RNA-binding domainF: Ribosomal_S15_2ECOD (1.6)
PA [auth Ci]Ribosomal_S11e6rxyCi1 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: Ribosomal_S11ECOD (1.6)
QA [auth Cj]Ribosomal_S9e6rxyCj1 A: a+b two layersX: Ribosomal protein S5 domain 2-like (From Topology)H: Ribosomal protein S5 domain 2-like (From Topology)T: Ribosomal protein S5 domain 2-likeF: Ribosomal_S9ECOD (1.6)
D [auth UD]ANAPC4_WD40_9e6rxyUD1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_9ECOD (1.6)
D [auth UD]ANAPC4_WD40_4e6rxyUD2 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_4ECOD (1.6)
RA [auth Cm]Ribosomal_S8_N_1e6rxyCm1 A: a+b two layersX: R3H domain-likeH: Ribosomal protein S8, N-terminal domain (From Topology)T: Ribosomal protein S8, N-terminal domainF: Ribosomal_S8_N_1ECOD (1.6)
RA [auth Cm]Ribosomal_S8_C_1e6rxyCm2 A: a+b two layersX: Ribosomal protein S8, C-terminal domain (From Topology)H: Ribosomal protein S8, C-terminal domain (From Topology)T: Ribosomal protein S8, C-terminal domainF: Ribosomal_S8_C_1ECOD (1.6)
SA [auth Cn]Ribosom_S12_S23e6rxyCn1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: Ribosom_S12_S23ECOD (1.6)
TA [auth Cp]Ribosomal_S28ee6rxyCp1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: Ribosomal_S28eECOD (1.6)
XA [auth UV]Nrap_D2e6rxyUV6 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: PAP/OAS1 substrate-binding domainF: Nrap_D2ECOD (1.6)
XA [auth UV]Nrap_D5e6rxyUV2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: PAP/OAS1 substrate-binding domainF: Nrap_D5ECOD (1.6)
XA [auth UV]Nrap_D3e6rxyUV4 A: a+b two layersX: Alpha-beta plaitsH: PAP/Archaeal CCA-adding enzyme, C-terminal domain (From Topology)T: PAP/Archaeal CCA-adding enzyme, C-terminal domainF: Nrap_D3ECOD (1.6)
XA [auth UV]UNK_F_TYPEe6rxyUV1 A: a+b two layersX: Alpha-beta plaitsH: PAP/Archaeal CCA-adding enzyme, C-terminal domain (From Topology)T: PAP/Archaeal CCA-adding enzyme, C-terminal domainF: UNK_F_TYPEECOD (1.6)
XA [auth UV]Nrape6rxyUV3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NrapECOD (1.6)
XA [auth UV]Nrap_D4e6rxyUV5 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: Nrap_D4ECOD (1.6)
YA [auth CV]KOG4008,Peripla_BP_4_Ce6rxyCV1 A: a+b two layersX: Alpha-beta plaitsH: RNA-binding domain, RBD (From Topology)T: RNA-binding domain, RBDF: KOG4008,Peripla_BP_4_CECOD (1.6)
EB [auth UI]UNK_F_TYPEe6rxyUI1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: UNK_F_TYPEECOD (1.6)
AB [auth UE]UNK_F_TYPEe6rxyUE1 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: UNK_F_TYPEECOD (1.6)
E [auth UF]TPR_11_6e6rxyUF1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: TPR_11_6ECOD (1.6)
CB [auth Cl]Ribosomal_S13e6rxyCl1 A: alpha arraysX: HhH/H2THH: H2TH (From Topology)T: H2THF: Ribosomal_S13ECOD (1.6)
DB [auth CX]Bystine6rxyCX1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: BystinECOD (1.6)
GB [auth Cz]TPR_11_6e6rxyCz1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: TPR_11_6ECOD (1.6)
G [auth UJ]UNK_F_TYPEe6rxyUJ2 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: UNK_F_TYPEECOD (1.6)
I [auth UL]ANAPC4_WD40_2e6rxyUL3 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_2ECOD (1.6)
I [auth UL]ANAPC4_WD40_14e6rxyUL1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_14ECOD (1.6)
I [auth UL]Utp12e6rxyUL2 A: alpha superhelicesX: Repetitive alpha hairpinsH: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 (From Topology)T: C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13F: Utp12ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionIdentifierDescriptionCommentsSource
A [auth UA]PF04003Dip2/Utp12 Family (Utp12)Dip2/Utp12 Family- FamilyFamily
A [auth UA]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
J [auth UM]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
J [auth UM]PF08625Utp13 specific WD40 associated domain (Utp13)Utp13 specific WD40 associated domainUtp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable o ...Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end [1].
DomainDomain
K [auth UN]PF04615Utp14 protein (Utp14)Utp14 protein- FamilyFamily
L [auth UO]PF09384UTP15 C terminal (UTP15_C)UTP15 C terminal- FamilyFamily
L [auth UO]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
M [auth UQ]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
O [auth UU]PF04192Utp21 specific WD40 associated putative domain (Utp21)Utp21 specific WD40 associated putative domainUtp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.DomainDomain
O [auth UU]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
Q [auth UZ]PF00687Ribosomal protein L1p/L10e family (Ribosomal_L1)Ribosomal protein L1p/L10e familyThis family includes prokaryotic L1 and eukaryotic L10.DomainDomain
R [auth CA],
S [auth CB]
PF01269Fibrillarin (Fibrillarin)Fibrillarin- DomainDomain
T [auth CC]PF08156NOP5NT (NUC127) domain (NOP5NT)NOP5NT (NUC127) domainThis N terminal domain is found in RNA-binding proteins of the NOP5 family [1].DomainDomain
T [auth CC]PF01798snoRNA binding domain, fibrillarin (Nop)snoRNA binding domain, fibrillarin- FamilyFamily
B [auth UB]PF04147Nop14-like family (Nop14)Nop14-like family- FamilyFamily
U [auth CD]PF08156NOP5NT (NUC127) domain (NOP5NT)NOP5NT (NUC127) domainThis N terminal domain is found in RNA-binding proteins of the NOP5 family [1].DomainDomain
U [auth CD]PF01798snoRNA binding domain, fibrillarin (Nop)snoRNA binding domain, fibrillarin- FamilyFamily
V [auth CE],
W [auth CF]
PF01248Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)Ribosomal protein L7Ae/L30e/S12e/Gadd45 familyThis family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].
DomainDomain
X [auth CG]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
Y [auth CH]PF05189RNA 3'-terminal phosphate cyclase (RTC), insert domain (RTC_insert)RNA 3'-terminal phosphate cyclase (RTC), insert domainRNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation o ...RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].
DomainDomain
Y [auth CH]PF01137RNA 3'-terminal phosphate cyclase (RTC)RNA 3'-terminal phosphate cyclaseRNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation o ...RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].
DomainDomain
Z [auth CI]PF08142AARP2CN (NUC121) domain (AARP2CN)AARP2CN (NUC121) domainThis domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU [1].DomainDomain
Z [auth CI]PF0495040S ribosome biogenesis protein Tsr1 and BMS1 C-terminal (RIBIOP_C)40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal- FamilyFamily
AA [auth CJ]PF00163Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)Ribosomal protein S4/S9 N-terminal domain- FamilyFamily
AA [auth CJ]PF01479S4 domain (S4)S4 domainThe S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.
DomainDomain
BA [auth CK]PF04427Brix domain (Brix)Brix domain- DomainDomain
CA [auth CL]PF04006Mpp10 protein (Mpp10)Mpp10 protein- FamilyFamily
DA [auth CM]PF04158Sof1-like domain (Sof1)Sof1-like domain- FamilyFamily
DA [auth CM]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
EA [auth CN],
FA [auth CO]
PF03587EMG1/NEP1 methyltransferase (EMG1)EMG1/NEP1 methyltransferase- FamilyFamily
C [auth UC]PF09368Sas10 C-terminal domain (Sas10)Sas10 C-terminal domainSas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.DomainDomain
GA [auth CP]PF17903Krr1 KH1 domain (KH_8)Krr1 KH1 domainThis entry represents the first KH domain in the KRR1 protein [1]. Krr1 is a ribosomal assembly factor. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif and is involved in binding another assembly factor, Kri1 [1].DomainDomain
IA [auth CR],
JA [auth CS]
PF13725Possible tRNA binding domain (tRNA_bind_2)Possible tRNA binding domain- FamilyFamily
IA [auth CR],
JA [auth CS]
PF08351tRNA(Met) cytidine acetyltransferase TmcA, N-terminal (TmcA_N)tRNA(Met) cytidine acetyltransferase TmcA, N-terminal- FamilyFamily
IA [auth CR],
JA [auth CS]
PF13718GNAT acetyltransferase 2 (GNAT_acetyltr_2)GNAT acetyltransferase 2- FamilyFamily
IA [auth CR],
JA [auth CS]
PF05127Helicase (Helicase_RecD)HelicaseThis domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble ...This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [1]. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [2].
DomainDomain
KA [auth CT]PF08698Fcf2 pre-rRNA processing (Fcf2)Fcf2 pre-rRNA processing- FamilyFamily
LA [auth Cc]PF00177Ribosomal protein S7p/S5e (Ribosomal_S7)Ribosomal protein S7p/S5eThis family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.DomainDomain
MA [auth Ce]PF01251Ribosomal protein S7e (Ribosomal_S7e)Ribosomal protein S7e- FamilyFamily
NA [auth Cg]PF00163Ribosomal protein S4/S9 N-terminal domain (Ribosomal_S4)Ribosomal protein S4/S9 N-terminal domain- FamilyFamily
NA [auth Cg]PF01479S4 domain (S4)S4 domainThe S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast pro ...The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.
DomainDomain
OA [auth Ch]PF00312Ribosomal protein S15 (Ribosomal_S15)Ribosomal protein S15- DomainDomain
PA [auth Ci]PF00411Ribosomal protein S11 (Ribosomal_S11)Ribosomal protein S11- FamilyFamily
QA [auth Cj]PF00380Ribosomal protein S9/S16 (Ribosomal_S9)Ribosomal protein S9/S16- FamilyFamily
D [auth UD]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat
RA [auth Cm]PF00410Ribosomal protein S8 (Ribosomal_S8)Ribosomal protein S8- DomainDomain
SA [auth Cn]PF00164Ribosomal protein S12/S23 (Ribosom_S12_S23)Ribosomal protein S12/S23- FamilyFamily
TA [auth Cp]PF01200Ribosomal protein S28e (Ribosomal_S28e)Ribosomal protein S28e- FamilyFamily
UA [auth CU]PF15375Domain of unknown function (DUF4602) (DUF4602)Domain of unknown function (DUF4602)- FamilyFamily
XA [auth UV]PF03813Nrap protein domain 1 (Nrap)Nrap protein domain 1Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1]. This domain has a nucleotidyltransferase structure.
DomainDomain
XA [auth UV]PF17403Nrap protein PAP/OAS-like domain (Nrap_D2)Nrap protein PAP/OAS-like domainMembers of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].
DomainDomain
XA [auth UV]PF17406Nrap protein PAP/OAS1-like domain 5 (Nrap_D5)Nrap protein PAP/OAS1-like domain 5Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].
DomainDomain
XA [auth UV]PF17407Nrap protein domain 6 (Nrap_D6)Nrap protein domain 6Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].
DomainDomain
XA [auth UV]PF17404Nrap protein domain 3 (Nrap_D3)Nrap protein domain 3Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].
DomainDomain
XA [auth UV]PF17405Nrap protein nucleotidyltransferase domain 4 (Nrap_D4)Nrap protein nucleotidyltransferase domain 4Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a ...Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].
DomainDomain
YA [auth CV]PF17799Rrp7 RRM-like N-terminal domain (RRM_Rrp7)Rrp7 RRM-like N-terminal domainThis domain corresponds to the N-terminal RNA-binding domain found in the Rrp7 protein. It has an RRM-like fold with a circular permutation [1].DomainDomain
YA [auth CV]PF12923Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain (RRP7)Ribosomal RNA-processing protein 7 (RRP7) C-terminal domainRRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly [1]. It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle [1-2].DomainDomain
AB [auth UE],
EB [auth UI]
PF04003Dip2/Utp12 Family (Utp12)Dip2/Utp12 Family- FamilyFamily
E [auth UF]PF08640U3 small nucleolar RNA-associated protein 6 (U3_assoc_6)U3 small nucleolar RNA-associated protein 6- FamilyFamily
BB [auth US]PF03914CBF/Mak21 family (CBF)CBF/Mak21 family- FamilyFamily
CB [auth Cl]PF00416Ribosomal protein S13/S18 (Ribosomal_S13)Ribosomal protein S13/S18- FamilyFamily
DB [auth CX]PF05291Bystin (Bystin)Bystin- FamilyFamily
FB [auth UP]PF08297U3 snoRNA associated (U3_snoRNA_assoc)U3 snoRNA associated- FamilyFamily
F [auth UG]PF08149BING4CT (NUC141) domain (BING4CT)BING4CT (NUC141) domainThis C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins [1].DomainDomain
G [auth UJ]PF12397U3 small nucleolar RNA-associated protein 10 (U3snoRNP10)U3 small nucleolar RNA-associated protein 10- FamilyFamily
H [auth UK]PF03998Utp11 protein (Utp11)Utp11 protein- FamilyFamily
I [auth UL]PF04003Dip2/Utp12 Family (Utp12)Dip2/Utp12 Family- FamilyFamily
I [auth UL]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- RepeatRepeat

Gene Product Annotation Gene Product Annotation

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth UA]Periodic tryptophan protein 2-like protein
      J [auth UM]Utp13
          K [auth UN]Utp14
              L [auth UO]Utp15
                  M [auth UQ]Utp17
                        N [auth UR]Utp18
                            O [auth UU]Utp21
                                P [auth UX]Utp24nonenonenone
                                Q [auth UZ]Utp30
                                    R [auth CA],
                                    S [auth CB]
                                    Nop1
                                      T [auth CC]Nop56
                                        B [auth UB]Utp2
                                          U [auth CD]Nop58
                                            V [auth CE],
                                            W [auth CF]
                                            Snu13
                                              X [auth CG]Rrp9
                                                  Y [auth CH]RNA 3'-terminal phosphate cyclase-like protein
                                                  Z [auth CI]Bms1
                                                    AA [auth CJ]Imp3
                                                        BA [auth CK]Imp4
                                                            CA [auth CL]Mpp10
                                                                DA [auth CM]Sof1
                                                                    EA [auth CN],
                                                                    FA [auth CO]
                                                                    Emg1
                                                                      C [auth UC]Utp3
                                                                            GA [auth CP]KRR1 small subunit processome component
                                                                              HA [auth CQ]Pre-rRNA-processing protein PNO1
                                                                              IA [auth CR],
                                                                              JA [auth CS]
                                                                              Kre33
                                                                              KA [auth CT]Fcf2
                                                                                  LA [auth Cc]40S ribosomal protein s5-like protein
                                                                                    MA [auth Ce]40S ribosomal protein S7
                                                                                      NA [auth Cg]40S ribosomal protein s9-like protein
                                                                                        OA [auth Ch]40S ribosomal protein S13-like protein
                                                                                          PA [auth Ci]40S ribosomal protein S14-like protein
                                                                                            QA [auth Cj]40S ribosomal protein S16-like protein
                                                                                              D [auth UD]Utp4
                                                                                                  RA [auth Cm]40S ribosomal protein S22-like protein
                                                                                                    SA [auth Cn]40S ribosomal protein s23-like protein
                                                                                                      TA [auth Cp]40S ribosomal protein S28-like protein
                                                                                                        UA [auth CU]Faf1
                                                                                                              VA [auth C1]35S rRNAnonenonenone
                                                                                                              WA [auth C2]U3 snoRNAnonenonenone
                                                                                                              XA [auth UV]U3 small nucleolar RNA-associated protein 22
                                                                                                                YA [auth CV]Rrp7
                                                                                                                      ZA [auth UH]Utp8
                                                                                                                          AB [auth UE],
                                                                                                                          EB [auth UI]
                                                                                                                          Utp5
                                                                                                                                E [auth UF]Utp6
                                                                                                                                  BB [auth US]Noc4
                                                                                                                                    CB [auth Cl]Rps18
                                                                                                                                      DB [auth CX]Enp1
                                                                                                                                          FB [auth UP]Utp16
                                                                                                                                              GB [auth Cz]Rrp5
                                                                                                                                                F [auth UG]Utp7
                                                                                                                                                    G [auth UJ]Utp10
                                                                                                                                                        H [auth UK]U3 small nucleolar RNA-associated protein 11
                                                                                                                                                            I [auth UL]Utp12