Annotations: 6YBA

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
M	Adeno_Penton_B_2nd	e6ybaM1	A: beta sandwiches	X: jelly-roll	H: Jelly-roll domain in Adenovirus penton base protein (From Topology)	T: Jelly-roll domain in Adenovirus penton base protein	F: Adeno_Penton_B_2nd	ECOD (1.6)
M	Adeno_Penton_B_1st	e6ybaM2	A: a+b complex topology	X: Insertion domain in Adenovirus penton base protein (From Topology)	H: Insertion domain in Adenovirus penton base protein (From Topology)	T: Insertion domain in Adenovirus penton base protein	F: Adeno_Penton_B_1st	ECOD (1.6)
A	Adeno_hexon	e6ybaA1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
A	Adeno_hexon_C	e6ybaA2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
B	Adeno_hexon	e6ybaB2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
B	Adeno_hexon_C	e6ybaB1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
C	Adeno_hexon	e6ybaC2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
C	Adeno_hexon_C	e6ybaC1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
D	Adeno_hexon	e6ybaD1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
D	Adeno_hexon_C	e6ybaD2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
E	Adeno_hexon	e6ybaE2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
E	Adeno_hexon_C	e6ybaE1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
F	Adeno_hexon	e6ybaF1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
F	Adeno_hexon_C	e6ybaF2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
G	Adeno_hexon	e6ybaG2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
G	Adeno_hexon_C	e6ybaG1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
H	Adeno_hexon	e6ybaH2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
H	Adeno_hexon_C	e6ybaH1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
J	Adeno_hexon	e6ybaJ1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
J	Adeno_hexon_C	e6ybaJ2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
K	Adeno_hexon	e6ybaK1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
K	Adeno_hexon_C	e6ybaK2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
L	Adeno_hexon	e6ybaL2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
L	Adeno_hexon_C	e6ybaL1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
I	Adeno_hexon	e6ybaI1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon	ECOD (1.6)
I	Adeno_hexon_C	e6ybaI2	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Adeno_hexon_C	ECOD (1.6)
N	Hex_IIIa	e6ybaN1	A: alpha arrays	X: N-terminal domain of hexon-associated protein (IIIa) (From Topology)	H: N-terminal domain of hexon-associated protein (IIIa) (From Topology)	T: N-terminal domain of hexon-associated protein (IIIa)	F: Hex_IIIa	ECOD (1.6)
N	Hex_IIIa	e6ybaN2	A: alpha bundles	X: Middle domain of hexon-associated protein (IIIa) (From Topology)	H: Middle domain of hexon-associated protein (IIIa) (From Topology)	T: Middle domain of hexon-associated protein (IIIa)	F: Hex_IIIa	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
M	PF01686	Adenovirus penton base protein (Adeno_Penton_B)	Adenovirus penton base protein	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF01065	Hexon, adenovirus major coat protein, N-terminal domain (Adeno_hexon)	Hexon, adenovirus major coat protein, N-terminal domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polype ...	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF03678	Hexon, adenovirus major coat protein, C-terminal domain (Adeno_hexon_C)	Hexon, adenovirus major coat protein, C-terminal domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polype ...	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer. The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	Domain
N	PF02455	Hexon-associated protein (IIIa) (Hex_IIIa)	Hexon-associated protein (IIIa)	-	Family
O, P	PF01310	Adenovirus hexon associated protein, protein VIII (Adeno_PVIII)	Adenovirus hexon associated protein, protein VIII	-	Family
Q, R, S, T	PF03955	Adenovirus hexon-associated protein (IX) (Adeno_PIX)	Adenovirus hexon-associated protein (IX)	-	Family
U, V, X [auth Y], Y [auth u]	PF02993	Minor capsid protein VI (MCPVI)	Minor capsid protein VI	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
M	Penton protein	structural molecule activity	virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction import into cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction import into cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell symbiont entry into host cellular process endocytosis involved in viral entry into host cell endocytosis transport of virus	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle viral capsid icosahedral viral capsid virion component T=25 icosahedral viral capsid
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Hexon protein	structural molecule activity	microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host biological process involved in interaction with host biological process involved in symbiotic interaction	host cellular component cellular anatomical structure host cell host intracellular membrane-bounded organelle host intracellular part host cell part host intracellular region host cell nucleus host intracellular organelle viral capsid icosahedral viral capsid virion component T=25 icosahedral viral capsid
N	Pre-hexon-linking protein IIIa	-	-	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle viral capsid virion component viral capsid, decoration
O, P	Pre-hexon-linking protein VIII	hexon binding protein binding binding	-	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle
Q, R, S, T	Hexon-interlacing protein	hexon binding protein binding binding	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle viral capsid virion component viral capsid, decoration
U, V, X [auth Y], Y [auth u]	Pre-protein VI	-	microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host lysis of host organelle involved in viral entry into host cell biological process involved in interaction with host biological process involved in symbiotic interaction exit from host cell microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host lysis of host organelle involved in viral entry into host cell biological process involved in interaction with host biological process involved in symbiotic interaction exit from host cell viral release from host cell	host cellular component cellular anatomical structure host cell viral capsid virion component viral procapsid host intracellular membrane-bounded organelle host intracellular part host cell part host intracellular region host cell nucleus host intracellular organelle host cell cytoplasm
W, Z [auth w]	Pre-histone-like nucleoprotein	DNA binding binding organic cyclic compound binding nucleic acid binding	viral penetration into host nucleus intracellular transport of virus viral process viral life cycle transport of virus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host biological process involved in interaction with host biological process involved in symbiotic interaction	host cellular component cellular anatomical structure host cell viral capsid virion component host intracellular membrane-bounded organelle host intracellular part host cell part host intracellular region host cell nucleus host cell nucleolus host cell nuclear part host intracellular organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
M	IPR002605	Adenovirus penton base protein	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR044942	Adenovirus Pll, hexon, subdomain 2	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR016110	Adenovirus Pll, hexon, subdomain 3	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR016107	Adenovirus Pll, hexon, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR016108	Adenovirus Pll, hexon, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR016112	Group II dsDNA virus coat/capsid protein	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR037542	Adenovirus hexon protein	Family
N	IPR003479	Pre-hexon-linking protein IIIa	Family
N	IPR043053	Pre-hexon-linking protein IIIa, N-terminal	Homologous Superfamily
O, P	IPR000646	Pre-hexon-linking protein VIII	Family
Q, R, S, T	IPR005641	Hexon-associated protein IX	Family
U, V, X [auth Y], Y [auth u]	IPR004243	Minor capsid protein VI	Family
W, Z [auth w]	IPR004912	Adenoviral core protein VII	Family