6E67

Structure of beta2 adrenergic receptor fused to a Gs peptide

Present annotations:

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Product Annotation
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lysozyme-like	8093428	3001879	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2B (2022-06-29)
B	SCOP2 Family	Phage lysozyme	8093427	4000895	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Lysozyme-like	8093428	3001879	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091150	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_3	e6e67A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
A	Phage_lysozyme_2	e6e67A2	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	7tm_1_3	e6e67B1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
B	Phage_lysozyme_2	e6e67B2	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A, B	PF00503	G-protein alpha subunit (G-alpha)	G-protein alpha subunit	G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ...	G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site [3]. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA [3].	Domain
A, B	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A, B	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera	lysozyme activity catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity enzyme activator activity cyclase regulator activity cyclase activator activity adenylate cyclase regulator activity adenylate cyclase activator activity enzyme regulator activity molecular function regulator activity molecular function activator activity binding G-protein beta/gamma-subunit complex binding protein-containing complex binding GTPase activity pyrophosphatase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ribonucleoside triphosphate phosphatase activity ion binding cation binding metal ion binding protein binding adenylate cyclase binding enzyme binding transmembrane signaling receptor activity G protein-coupled receptor activity adrenergic receptor activity beta-adrenergic receptor activity beta2-adrenergic receptor activity G protein-coupled amine receptor activity signaling receptor activity molecular transducer activity identical protein binding norepinephrine binding organic cyclic compound binding catecholamine binding potassium channel regulator activity channel regulator activity ion channel regulator activity protein homodimerization activity protein dimerization activity	metabolic process catabolic process macromolecule catabolic process cellular process cell wall macromolecule catabolic process macromolecule metabolic process cell wall macromolecule metabolic process cell wall organization or biogenesis organic substance metabolic process organic substance catabolic process cytolysis response to endogenous stimulus response to organic substance response to organonitrogen compound response to organic cyclic compound response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to organic substance cellular response to organic cyclic compound cellular response to organonitrogen compound cellular response to endogenous stimulus response to monoamine cellular response to monoamine stimulus response to catecholamine cellular response to catecholamine stimulus response to nitrogen compound cellular response to nitrogen compound response to oxygen-containing compound cellular response to oxygen-containing compound response to hormone cellular response to hormone stimulus response to lipid response to prostaglandin response to prostaglandin E cellular response to prostaglandin stimulus cellular response to prostaglandin E stimulus cellular response to lipid response to alcohol cellular response to alcohol response to ketone cellular response to ketone developmental process growth developmental growth positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity positive regulation of molecular function regulation of catalytic activity regulation of hydrolase activity positive regulation of hydrolase activity biological regulation regulation of molecular function cell differentiation fat cell differentiation cellular developmental process brown fat cell differentiation response to peptide cellular response to peptide response to amyloid-beta cellular response to amyloid-beta multicellular organismal process multicellular organism growth regulation of growth regulation of multicellular organism growth negative regulation of multicellular organism growth negative regulation of growth negative regulation of biological process regulation of developmental growth negative regulation of developmental growth regulation of biological process regulation of developmental process negative regulation of developmental process regulation of multicellular organismal process negative regulation of multicellular organismal process	host cellular component host cell cytoplasm host cell part host intracellular part host intracellular region host cell cellular anatomical entity intracellular anatomical structure cytoplasm cytosol extracellular region extracellular space vesicle organelle membrane-bounded organelle extracellular organelle extracellular membrane-bounded organelle extracellular exosome extracellular vesicle heterotrimeric G-protein complex plasma membrane cytoplasmic side of plasma membrane membrane extrinsic component of plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane protein-containing complex cell periphery side of membrane cytoplasmic side of membrane membrane protein complex plasma membrane protein complex catalytic complex GTPase complex Golgi apparatus trans-Golgi network endomembrane system organelle membrane organelle subcompartment trans-Golgi network membrane intracellular organelle intracellular membrane-bounded organelle Golgi apparatus subcompartment apical plasma membrane apical part of cell plasma membrane region vesicle membrane coated vesicle clathrin-coated vesicle endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane clathrin-coated vesicle membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane cytoplasmic vesicle clathrin-coated endocytic vesicle intracellular vesicle bounding membrane of organelle endosome early endosome endosome membrane nucleus receptor complex

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	β₂ adrenergic receptor fused to a Gs peptide

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.