Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth C]SCOP2B SuperfamilyVirus ectodomain8085614 3001628 SCOP2B (2022-02-25)
C [auth J]SCOP2B SuperfamilyVirus ectodomain8085614 3001628 SCOP2B (2022-02-25)
E [auth Q]SCOP2B SuperfamilyVirus ectodomain8085614 3001628 SCOP2B (2022-02-25)
B [auth G]SCOP2B Superfamilygp120 core8080371 3001390 SCOP2B (2022-02-25)
D [auth K]SCOP2B Superfamilygp120 core8080371 3001390 SCOP2B (2022-02-25)
F [auth R]SCOP2B Superfamilygp120 core8080371 3001390 SCOP2B (2022-02-25)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth C]GP41_1ste6ornC1 A: a+b duplicates or obligate multimersX: MPER trimer (From Topology)H: MPER trimer (From Topology)T: MPER trimerF: GP41_1stECOD (1.6)
C [auth J]GP41_1ste6ornJ1 A: a+b duplicates or obligate multimersX: MPER trimer (From Topology)H: MPER trimer (From Topology)T: MPER trimerF: GP41_1stECOD (1.6)
E [auth Q]GP41_1ste6ornQ1 A: a+b duplicates or obligate multimersX: MPER trimer (From Topology)H: MPER trimer (From Topology)T: MPER trimerF: GP41_1stECOD (1.6)
B [auth G]GP120_2nde6ornG3 A: beta barrelsX: V1/V2 domain in HIV gp120 (From Topology)H: V1/V2 domain in HIV gp120 (From Topology)T: V1/V2 domain in HIV gp120F: GP120_2ndECOD (1.6)
B [auth G]GP120_3rde6ornG1 A: a+b two layersX: Ribosomal protein L31e-likeH: Ribosomal protein L31e/gp120 outer domain (From Topology)T: Ribosomal protein L31e/gp120 outer domainF: GP120_3rdECOD (1.6)
B [auth G]GP120_1ste6ornG2 A: a+b two layersX: gp120 inner domain (From Topology)H: gp120 inner domain (From Topology)T: gp120 inner domainF: GP120_1stECOD (1.6)
D [auth K]GP120_2nde6ornK3 A: beta barrelsX: V1/V2 domain in HIV gp120 (From Topology)H: V1/V2 domain in HIV gp120 (From Topology)T: V1/V2 domain in HIV gp120F: GP120_2ndECOD (1.6)
D [auth K]GP120_3rde6ornK1 A: a+b two layersX: Ribosomal protein L31e-likeH: Ribosomal protein L31e/gp120 outer domain (From Topology)T: Ribosomal protein L31e/gp120 outer domainF: GP120_3rdECOD (1.6)
D [auth K]GP120_1ste6ornK2 A: a+b two layersX: gp120 inner domain (From Topology)H: gp120 inner domain (From Topology)T: gp120 inner domainF: GP120_1stECOD (1.6)
F [auth R]GP120_2nde6ornR2 A: beta barrelsX: V1/V2 domain in HIV gp120 (From Topology)H: V1/V2 domain in HIV gp120 (From Topology)T: V1/V2 domain in HIV gp120F: GP120_2ndECOD (1.6)
F [auth R]GP120_3rde6ornR1 A: a+b two layersX: Ribosomal protein L31e-likeH: Ribosomal protein L31e/gp120 outer domain (From Topology)T: Ribosomal protein L31e/gp120 outer domainF: GP120_3rdECOD (1.6)
F [auth R]GP120_1ste6ornR3 A: a+b two layersX: gp120 inner domain (From Topology)H: gp120 inner domain (From Topology)T: gp120 inner domainF: GP120_1stECOD (1.6)
G [auth A]V-set_8e6ornA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
H [auth F]V-set_8e6ornF1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
I [auth O]V-set_8e6ornO1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
J [auth B]V-set_3e6ornB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
K [auth I]V-set_3e6ornI1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
L [auth P]V-set_3e6ornP1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
G [auth A],
H [auth F],
I [auth O]
Fab 10-1074, broadly neutralizing antibody VH Homo sapiens (human) IGHV4-59*01, IGHV4-59*02, IGHV4-59*08, IGHV4-4*08 V-DOMAIN VH IG FAB-GAMMA-1_KAPPA IMGT (202140-0)
J [auth B],
K [auth I],
L [auth P]
Fab 10-1074, broadly neutralizing antibody L-LAMBDA Homo sapiens (human) IGLV3-21*01, IGLJ2*01, IGLJ7*01, IGLJ3*01, IGLC2*01, IGLC2*02, IGLC3*04 V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA IG FAB-GAMMA-1_KAPPA IMGT (202140-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
G [auth A],
H [auth F],
I [auth O]
Heavy ChainIGHV4 -rc1 variant of hiv-1 env glycoprotein gp120SAbDab (2021-10-13)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionIdentifierDescriptionCommentsSource
A [auth C],
C [auth J],
E [auth Q]
PF00517Retroviral envelope protein (GP41)Retroviral envelope protein- Family
B [auth G],
D [auth K],
F [auth R]
PF00516Envelope glycoprotein GP120 (GP120)Envelope glycoprotein GP120- Family

Gene Product Annotation Gene Product Annotation

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth C],
C [auth J],
E [auth Q]
RC1 variant of HIV-1 Env glycoprotein gp41
B [auth G],
D [auth K],
F [auth R]
RC1 variant of HIV-1 Env glycoprotein gp120
G [auth A],
H [auth F],
I [auth O]
10-1074 antibody Fab heavy chainnonenonenone
J [auth B],
K [auth I],
L [auth P]
10-1074 antibody Fab light chainnonenonenone