Annotations: 7BU7

Domain Annotation: SCOP/SCOPe Classification SCOP Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d7bu7b1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Camelidae mixed library ) [TaxId: 1579311 ],	SCOPe (2.08)
B	d7bu7b3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Camelidae mixed library ) [TaxId: 1579311 ],	SCOPe (2.08)
B	d7bu7b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Camelidae mixed library ) [TaxId: 1579311 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8103350	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_2	e7bu7A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
A	Phage_lysozyme_2	e7bu7A2	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	V-set_1	e7bu7B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_1	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	nAb 6B9	VH	Vicugna pacos (alpaca)	IGHV3S5301, IGHJ401	V-DOMAIN VH	IG	VH	IMGT (202307-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	endolysin,endolysin,beta-1 adrenergic receptor chimera	SAbDab (2023-03-01)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Identifier	Description	Comments	Source
A	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Endolysin,Endolysin,Beta-1 adrenergic receptor chimera	transmembrane signaling receptor activity G protein-coupled receptor activity adrenergic receptor activity beta-adrenergic receptor activity G protein-coupled amine receptor activity signaling receptor activity molecular transducer activity beta1-adrenergic receptor activity neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity G protein-coupled neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential guanyl-nucleotide exchange factor activity enzyme regulator activity GTPase regulator activity nucleoside-triphosphatase regulator activity molecular function regulator activity binding protein binding protein domain specific binding PDZ domain binding protein heterodimerization activity protein dimerization activity lysozyme activity catalytic activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity	cellular process cell differentiation developmental process fat cell differentiation cellular developmental process brown fat cell differentiation multicellular organismal process multicellular organism growth growth regulation of growth regulation of multicellular organism growth negative regulation of multicellular organism growth negative regulation of growth negative regulation of biological process developmental growth regulation of developmental growth negative regulation of developmental growth regulation of biological process regulation of developmental process negative regulation of developmental process regulation of multicellular organismal process negative regulation of multicellular organismal process biological regulation positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity positive regulation of molecular function regulation of catalytic activity regulation of hydrolase activity positive regulation of hydrolase activity regulation of molecular function metabolic process catabolic process macromolecule catabolic process cell wall macromolecule catabolic process macromolecule metabolic process cell wall macromolecule metabolic process cell wall organization or biogenesis organic substance metabolic process organic substance catabolic process cytolysis	intracellular anatomical structure cytoplasm endosome early endosome endomembrane system cytoplasmic vesicle vesicle organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular vesicle cellular anatomical entity plasma membrane membrane cell periphery cell junction synapse Schaffer collateral - CA1 synapse host cellular component host cell cytoplasm host cell part host intracellular part host intracellular region host cell
B	camelid antibody fragment	none	none	none

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	β₁ adrenergic receptor bound to carazolol

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.