7BU7

Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9

Present annotations:

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Product Annotation
InterPro Annotation
Disease Associations: Pharos
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d7bu7b1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Camelidae mixed library ) [TaxId: 1579311 ],	SCOPe (2.08)
B	d7bu7b3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Camelidae mixed library ) [TaxId: 1579311 ],	SCOPe (2.08)
B	d7bu7b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Camelidae mixed library ) [TaxId: 1579311 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8103350	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	V-set_1	e7bu7B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_1	ECOD (1.6)
A	7tm_1_2	e7bu7A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
A	Phage_lysozyme_2	e7bu7A2	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B	nAb 6B9	VH	Vicugna pacos (alpaca)	IGHV3S5301, IGHJ401	V-DOMAIN VH	IG	VH	IMGT (202346-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	endolysin,endolysin,beta-1 adrenergic receptor chimera	SAbDab (2023-11-24)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	camelid antibody fragment	-	-	-
A	Endolysin,Endolysin,Beta-1 adrenergic receptor chimera	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity G protein-coupled amine receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity adrenergic receptor activity neurotransmitter receptor activity hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity G protein-coupled amine receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity adrenergic receptor activity neurotransmitter receptor activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled neurotransmitter receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential protein binding binding PDZ domain binding protein domain specific binding protein heterodimerization activity protein dimerization activity beta1-adrenergic receptor activity adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding alpha-2A adrenergic receptor binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process organic substance metabolic process aminoglycan metabolic process peptidoglycan metabolic process nitrogen compound metabolic process metabolic process macromolecule metabolic process organic substance catabolic process viral life cycle disruption of cell in another organism biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis movement in host disruption of cellular anatomical structure in another organism exit from host cell killing by symbiont of host cells viral process cellular process viral release from host cell disruption of anatomical structure in another organism killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cytolysis by symbiont of host cells cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process response to extracellular stimulus multicellular organismal process response to nutrient levels homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis response to dietary excess diet induced thermogenesis energy homeostasis response to abiotic stimulus response to cold response to temperature stimulus heart process system process regulation of systemic arterial blood pressure mediated by a chemical signal regulation of heart contraction regulation of system process positive regulation of biological process positive regulation of blood pressure positive regulation of blood circulation regulation of systemic arterial blood pressure by norepinephrine-epinephrine circulatory system process positive regulation of blood pressure by epinephrine-norepinephrine regulation of multicellular organismal process regulation of biological quality blood circulation regulation of heart rate regulation of biological process regulation of blood pressure biological regulation positive regulation of heart rate positive regulation of heart rate by epinephrine-norepinephrine positive regulation of heart contraction regulation of blood circulation regulation of systemic arterial blood pressure positive regulation of multicellular organismal process heart contraction rhythmic process circadian sleep/wake cycle, sleep circadian sleep/wake cycle rhythmic behavior regulation of circadian sleep/wake cycle circadian rhythm regulation of circadian rhythm regulation of behavior behavior circadian behavior sleep regulation of circadian sleep/wake cycle, sleep circadian sleep/wake cycle process positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity fear response multicellular organismal response to stress developmental process regulation of multicellular organism growth regulation of growth regulation of developmental growth negative regulation of multicellular organism growth regulation of developmental process developmental growth negative regulation of developmental process growth negative regulation of biological process multicellular organism growth negative regulation of developmental growth negative regulation of growth negative regulation of multicellular organismal process positive regulation of metabolic process regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis regulation of metabolic process cellular response to stimulus adenylate cyclase-activating adrenergic receptor signaling pathway regulation of cellular process signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation regulation of the force of heart contraction by chemical signal regulation of the force of heart contraction positive regulation of the force of heart contraction by chemical signal positive regulation of the force of heart contraction by epinephrine-norepinephrine regulation of tube diameter regulation of tube size norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure negative regulation of blood pressure negative regulation of systemic arterial blood pressure vascular process in circulatory system blood vessel diameter maintenance vasodilation regulation of anatomical structure size heat generation	host cellular component host intracellular part host cell cytoplasm host cell part host cell host intracellular region cellular anatomical entity membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell host intracellular region cellular anatomical entity membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle neuronal dense core vesicle cell periphery plasma membrane membrane early endosome endosome Schaffer collateral - CA1 synapse synapse cell junction

InterPro Annotation InterPro: Classification of protein families

Chains	Accession	Name	Type
A	IPR001165	T4-type lysozyme	Family
A	IPR034690	Endolysin T4 type	Family
A	IPR002196	Glycoside hydrolase, family 24	Family
A	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR002233	Adrenoceptor family	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A	IPR000507	Beta 1 adrenoceptor	Family

Disease Associations: Pharos Pharos: Illuminating the Druggable Genome

Chains	Drug Target	Associated Disease
A	Pharos: P08588	hypertensive disorder dilated cardiomyopathy endomyocardial fibrosis congestive heart failure Ventricular Dysfunction obesity disorder cardiovascular disease diabetes mellitus interstitial lung disease pilocytic astrocytoma lung carcinoma pulmonary emphysema sinusitis asthma gastric cancer hypertensive disorder dilated cardiomyopathy endomyocardial fibrosis congestive heart failure Ventricular Dysfunction obesity disorder cardiovascular disease diabetes mellitus interstitial lung disease pilocytic astrocytoma lung carcinoma pulmonary emphysema sinusitis asthma gastric cancer atopic eczema tuberculosis glioblastoma atrioventricular block heart failure bronchiectasis open-angle glaucoma osteosarcoma chronic obstructive pulmonary disease invasive ductal breast carcinoma coronary artery disease primitive neuroectodermal tumor depressive disorder malignant ependymoma acute coronary syndrome dilated cardiomyopathy 1A malignant pancreatic neoplasm essential tremor gastric neoplasm myocardial infarction atrial fibrillation head and neck cancer atypical teratoid rhabdoid tumor ventricular fibrillation ocular hypertension bronchitis hereditary diffuse gastric adenocarcinoma hypertrophic cardiomyopathy Parkinson disease interstitial cystitis common cold large cell medulloblastoma Crohn disease lung adenocarcinoma psoriasis malignant glioma ductal breast carcinoma in situ medulloblastoma exocrine pancreatic carcinoma astrocytic tumor glaucoma myocardial ischemia non-small cell lung carcinoma hemangioma oligodendroglioma cardiac arrest

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	β₁ adrenergic receptor bound to carazolol

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.