7LXT

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib

Present annotations:

Gene Product Annotation

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, O	20S proteasome alpha-1 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
B, P	20S proteasome alpha-2 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
C, Q	20S proteasome alpha-3 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
D, R	20S proteasome alpha-4 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
E, S	20S proteasome alpha-5 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
F, T	20S proteasome alpha-6 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
G, U	20S proteasome alpha-7 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
H, V	20S proteasome beta-1 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
I, W	20S proteasome beta-2 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
J, X	20S proteasome beta-3 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
K, Y	20S proteasome beta-4 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
L, Z	20S proteasome beta-5 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
AA [auth a], M	20S proteasome beta-6 subunit	catalytic activity endopeptidase activity threonine-type endopeptidase activity peptidase activity hydrolase activity threonine-type peptidase activity catalytic activity, acting on a protein		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
BA [auth b], N	20S proteasome beta-7 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity		intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.