7LXT

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib

Present annotations:

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Product Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
O	SCOP2B Superfamily	Class II glutamine amidotransferases	8064070	3000131	SCOP2B (2022-02-25)
A	SCOP2B Superfamily	Class II glutamine amidotransferases	8064070	3000131	SCOP2B (2022-02-25)
B	SCOP2B Superfamily	Class II glutamine amidotransferases	8064034	3000131	SCOP2B (2022-02-25)
P	SCOP2B Superfamily	Class II glutamine amidotransferases	8064034	3000131	SCOP2B (2022-02-25)
C	SCOP2B Superfamily	Class II glutamine amidotransferases	8064028	3000131	SCOP2B (2022-02-25)
Q	SCOP2B Superfamily	Class II glutamine amidotransferases	8064028	3000131	SCOP2B (2022-02-25)
R	SCOP2B Superfamily	Class II glutamine amidotransferases	8064032	3000131	SCOP2B (2022-02-25)
D	SCOP2B Superfamily	Class II glutamine amidotransferases	8064032	3000131	SCOP2B (2022-02-25)
E	SCOP2B Superfamily	Class II glutamine amidotransferases	8064024	3000131	SCOP2B (2022-02-25)
S	SCOP2B Superfamily	Class II glutamine amidotransferases	8064024	3000131	SCOP2B (2022-02-25)
F	SCOP2B Superfamily	Class II glutamine amidotransferases	8064064	3000131	SCOP2B (2022-02-25)
T	SCOP2B Superfamily	Class II glutamine amidotransferases	8064064	3000131	SCOP2B (2022-02-25)
G	SCOP2B Superfamily	Class II glutamine amidotransferases	8064068	3000131	SCOP2B (2022-02-25)
U	SCOP2B Superfamily	Class II glutamine amidotransferases	8064068	3000131	SCOP2B (2022-02-25)
I	SCOP2B Superfamily	Class II glutamine amidotransferases	8064072	3000131	SCOP2B (2022-02-25)
W	SCOP2B Superfamily	Class II glutamine amidotransferases	8064072	3000131	SCOP2B (2022-02-25)
L	SCOP2B Superfamily	Class II glutamine amidotransferases	8079498	3000131	SCOP2B (2022-02-25)
Z	SCOP2B Superfamily	Class II glutamine amidotransferases	8079498	3000131	SCOP2B (2022-02-25)
AA [auth a]	SCOP2 Family	Proteasome subunits	8104220	4002254	SCOP2 (2022-02-25)
AA [auth a]	SCOP2 Superfamily	Class II glutamine amidotransferases	8104221	3000131	SCOP2 (2022-02-25)
M	SCOP2B Superfamily	Class II glutamine amidotransferases	8104221	3000131	SCOP2B (2022-02-25)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
O	F_UNCLASSIFIED	e7lxtO1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7lxtA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7lxtB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
P	F_UNCLASSIFIED	e7lxtP1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7lxtC1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
Q	F_UNCLASSIFIED	e7lxtQ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
R	F_UNCLASSIFIED	e7lxtR1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7lxtD1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e7lxtE1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
S	F_UNCLASSIFIED	e7lxtS1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e7lxtF1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
T	F_UNCLASSIFIED	e7lxtT1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e7lxtG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
U	F_UNCLASSIFIED	e7lxtU1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
H	F_UNCLASSIFIED	e7lxtH1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
V	F_UNCLASSIFIED	e7lxtV1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
I	F_UNCLASSIFIED	e7lxtI1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
W	F_UNCLASSIFIED	e7lxtW1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
J	F_UNCLASSIFIED	e7lxtJ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
X	F_UNCLASSIFIED	e7lxtX1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
K	F_UNCLASSIFIED	e7lxtK1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
Y	F_UNCLASSIFIED	e7lxtY1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
L	F_UNCLASSIFIED	e7lxtL1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
Z	F_UNCLASSIFIED	e7lxtZ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
AA [auth a]	F_UNCLASSIFIED	e7lxta1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
M	F_UNCLASSIFIED	e7lxtM1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
BA [auth b]	F_UNCLASSIFIED	e7lxtb1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)
N	F_UNCLASSIFIED	e7lxtN1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Cellular Component
A, O	20S proteasome alpha-1 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
B, P	20S proteasome alpha-2 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein
C, Q	20S proteasome alpha-3 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cytosol cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
D, R	20S proteasome alpha-4 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
E, S	20S proteasome alpha-5 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
F, T	20S proteasome alpha-6 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein
G, U	20S proteasome alpha-7 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
H, V	20S proteasome beta-1 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity
I, W	20S proteasome beta-2 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
J, X	20S proteasome beta-3 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
K, Y	20S proteasome beta-4 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
L, Z	20S proteasome beta-5 subunit	catalytic activity endopeptidase activity peptidase activity hydrolase activity catalytic activity, acting on a protein threonine-type endopeptidase activity threonine-type peptidase activity	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
AA [auth a], M	20S proteasome beta-6 subunit	catalytic activity hydrolase activity	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle
BA [auth b], N	20S proteasome beta-7 subunit	catalytic activity endopeptidase activity threonine-type endopeptidase activity peptidase activity hydrolase activity threonine-type peptidase activity catalytic activity, acting on a protein	intracellular anatomical structure cytoplasm cellular anatomical entity nucleus organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle

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7LXT

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib

Present annotations:

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Gene Product Annotation Gene Product Annotation