7OZ1

Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound

Present annotations:

Domain Annotation: ECOD Classification
Gene Product Annotation
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e7oz1A2	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type II ABC exporter transmembrane domain-related	T: ABCG5/ABCG8 transmembrane domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7oz1A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7oz1B2	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type II ABC exporter transmembrane domain-related	T: ABCG5/ABCG8 transmembrane domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7oz1B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Isoform 4 of ATP-binding cassette sub-family G member 1	transporter activity lipid transporter activity sterol transporter activity primary active transmembrane transporter activity active transmembrane transporter activity transmembrane transporter activity ATPase-coupled lipid transmembrane transporter activity ABC-type sterol transporter activity ATPase-coupled transmembrane transporter activity ABC-type transporter activity ATP-dependent activity organic hydroxy compound transmembrane transporter activity binding steroid binding lipid binding cholesterol binding sterol binding small molecule binding alcohol binding organic cyclic compound binding lipid transfer activity sterol transfer activity cholesterol transfer activity intramembrane lipid transporter activity ATPase-coupled intramembrane lipid transporter activity floppase activity phospholipid transporter activity phosphatidylcholine transporter activity phosphatidylcholine floppase activity phospholipid binding protein binding protein heterodimerization activity protein dimerization activity identical protein binding protein homodimerization activity toxin transmembrane transporter activity	cellular process response to stimulus cellular response to stimulus cellular response to lipoprotein particle stimulus cellular response to high density lipoprotein particle stimulus homeostatic process cholesterol homeostasis chemical homeostasis lipid homeostasis sterol homeostasis biological regulation regulation of biological quality cellular component organization multicellular organismal process protein-containing complex remodeling protein-lipid complex remodeling plasma lipoprotein particle remodeling high-density lipoprotein particle remodeling protein-containing complex organization regulation of biological process protein-lipid complex subunit organization plasma lipoprotein particle organization cellular component organization or biogenesis regulation of plasma lipoprotein particle levels low-density lipoprotein particle remodeling lipid localization cholesterol storage regulation of lipid storage regulation of cholesterol storage negative regulation of cholesterol storage negative regulation of lipid storage lipid storage regulation of localization macromolecule localization negative regulation of biological process localization maintenance of location regulation of lipid localization negative regulation of lipid localization macrophage derived foam cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation cell differentiation developmental process regulation of cell differentiation negative regulation of cell differentiation negative regulation of cellular process cellular developmental process regulation of developmental process regulation of cellular process negative regulation of developmental process foam cell differentiation phospholipid homeostasis response to organic substance response to lipid response to chemical	intracellular anatomical structure cytoplasm endoplasmic reticulum endoplasmic reticulum membrane endomembrane system membrane organelle membrane organelle subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle endoplasmic reticulum subcompartment cellular anatomical entity endosome cytoplasmic vesicle vesicle intracellular vesicle plasma membrane external side of plasma membrane cell surface cell periphery side of membrane Golgi apparatus integral component of membrane intrinsic component of membrane mitochondrion recycling endosome

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	ABC transporters	ABC transporter G family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.