Annotations: 7RPH

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02460	Patched SSD (Patched)	Patched SSD	The transmembrane protein Patched Swiss:P18502 is a receptor for the morphogenic Sonic Hedgehog. This protein associates with the smoothened protein (SMO) to transduce hedgehog signals. These proteins consist of twelve transmembrane segments and two ...	The transmembrane protein Patched Swiss:P18502 is a receptor for the morphogenic Sonic Hedgehog. This protein associates with the smoothened protein (SMO) to transduce hedgehog signals. These proteins consist of twelve transmembrane segments and two extracellular domains (ECDs) [1,2]. This entry represents the Sterol-sensing domain (SSD) formed by some of the TM segments. This domain may play a role in the transport and/or regulation of the SMO ligand [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein dispatched homolog 1	-	developmental process multicellular organism development multicellular organismal process determination of bilateral symmetry anatomical structure development pattern specification process determination of left/right symmetry left/right pattern formation regionalization specification of symmetry embryonic pattern specification embryo development peptide hormone processing regulation of hormone levels developmental process multicellular organism development multicellular organismal process determination of bilateral symmetry anatomical structure development pattern specification process determination of left/right symmetry left/right pattern formation regionalization specification of symmetry embryonic pattern specification embryo development peptide hormone processing regulation of hormone levels biological regulation signaling receptor ligand precursor processing primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process protein maturation patched ligand maturation biosynthetic process proteolysis protein processing metabolic process cellular process amide metabolic process protein metabolic process macromolecule metabolic process regulation of biological quality peptide transport localization nitrogen compound transport amide transport transport establishment of localization diaphragm development animal organ development muscle structure development skeletal muscle organ development respiratory system development muscle organ development system development dorsal/ventral pattern formation	cellular anatomical structure membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR052081	Dispatched hedgehog regulator	Family
A	IPR053958	HMGCR/SNAP/NPC1-like, sterol-sensing domain	Domain
A	IPR004869	Membrane transport protein MMPL domain	Domain
A	IPR000731	Sterol-sensing domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Resistance-nodulation-cell division	Patched family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Multi-Drug Efflux Transporters	Dispatched-1 (DISP1) homolog of the Hedgehog (Hh) signaling pathway, 'R' conformation

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.