7RTB

Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)

Present annotations:

Domain Annotation: SCOP2 Classification
Gene Product Annotation
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth G]	SCOP2B Superfamily	Transducin (heterotrimeric G protein) gamma chain	8070798	3001771	SCOP2B (2022-02-25)
E [auth R]	SCOP2B Superfamily	FnI-like domain	8086309	3000979	SCOP2B (2022-02-25)
E [auth R]	SCOP2B Superfamily	G protein-coupled receptor-like	8091126	3000473	SCOP2B (2022-02-25)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	catalytic activity phosphoric diester hydrolase activity hydrolase activity hydrolase activity, acting on ester bonds phosphoric ester hydrolase activity alkylglycerophosphoethanolamine phosphodiesterase activity binding protein binding G-protein gamma-subunit binding GTPase activity pyrophosphatase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ribonucleoside triphosphate phosphatase activity enzyme binding GTPase binding protein-containing complex binding cytoskeletal protein binding spectrin binding	cell population proliferation cellular process response to endogenous stimulus response to organic substance response to organonitrogen compound response to organic cyclic compound response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to organic substance cellular response to organic cyclic compound cellular response to organonitrogen compound cellular response to endogenous stimulus response to monoamine cellular response to monoamine stimulus response to catecholamine cellular response to catecholamine stimulus response to nitrogen compound cellular response to nitrogen compound response to oxygen-containing compound cellular response to oxygen-containing compound response to hormone cellular response to hormone stimulus response to lipid response to prostaglandin response to prostaglandin E cellular response to prostaglandin stimulus cellular response to prostaglandin E stimulus cellular response to lipid response to alcohol cellular response to alcohol response to ketone cellular response to ketone	cell body cellular anatomical entity intracellular anatomical structure cytoplasm cytosol dendrite somatodendritic compartment cell projection neuron projection dendritic tree plasma membrane bounded cell projection extracellular region extracellular space vesicle organelle membrane-bounded organelle extracellular organelle extracellular membrane-bounded organelle extracellular exosome extracellular vesicle heterotrimeric G-protein complex plasma membrane cytoplasmic side of plasma membrane membrane extrinsic component of plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane protein-containing complex cell periphery side of membrane cytoplasmic side of membrane membrane protein complex plasma membrane protein complex catalytic complex GTPase complex cell junction synapse
A	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	enzyme activator activity cyclase regulator activity adenylate cyclase activator activity enzyme regulator activity molecular function regulator activity binding G-protein beta/gamma-subunit complex binding protein-containing complex binding catalytic activity GTPase activity pyrophosphatase activity hydrolase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ribonucleoside triphosphate phosphatase activity ion binding cation binding metal ion binding	response to endogenous stimulus cellular process response to organic substance response to organonitrogen compound response to organic cyclic compound response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to organic substance cellular response to organic cyclic compound cellular response to organonitrogen compound cellular response to endogenous stimulus response to monoamine cellular response to monoamine stimulus response to catecholamine cellular response to catecholamine stimulus response to nitrogen compound cellular response to nitrogen compound response to oxygen-containing compound cellular response to oxygen-containing compound response to hormone cellular response to hormone stimulus response to lipid response to prostaglandin response to prostaglandin E cellular response to prostaglandin stimulus cellular response to prostaglandin E stimulus cellular response to lipid response to alcohol cellular response to alcohol response to ketone cellular response to ketone developmental process growth developmental growth positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity positive regulation of molecular function regulation of catalytic activity regulation of hydrolase activity positive regulation of hydrolase activity biological regulation regulation of molecular function	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol extracellular region extracellular space vesicle organelle membrane-bounded organelle extracellular organelle extracellular membrane-bounded organelle extracellular exosome extracellular vesicle heterotrimeric G-protein complex plasma membrane cytoplasmic side of plasma membrane membrane extrinsic component of plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane protein-containing complex cell periphery side of membrane cytoplasmic side of membrane membrane protein complex plasma membrane protein complex catalytic complex GTPase complex intrinsic component of membrane Golgi apparatus trans-Golgi network endomembrane system organelle membrane organelle subcompartment trans-Golgi network membrane intracellular organelle intracellular membrane-bounded organelle Golgi apparatus subcompartment
C [auth G]	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	binding protein binding G-protein beta-subunit binding	cell population proliferation cellular process response to endogenous stimulus response to organic substance response to organonitrogen compound response to organic cyclic compound response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to organic substance cellular response to organic cyclic compound cellular response to organonitrogen compound cellular response to endogenous stimulus response to monoamine cellular response to monoamine stimulus response to catecholamine cellular response to catecholamine stimulus response to nitrogen compound cellular response to nitrogen compound response to oxygen-containing compound cellular response to oxygen-containing compound response to hormone cellular response to hormone stimulus response to lipid response to prostaglandin response to prostaglandin E cellular response to prostaglandin stimulus cellular response to prostaglandin E stimulus cellular response to lipid response to alcohol cellular response to alcohol response to ketone cellular response to ketone	extracellular region extracellular space vesicle organelle membrane-bounded organelle extracellular organelle extracellular membrane-bounded organelle extracellular exosome cellular anatomical entity extracellular vesicle intracellular anatomical structure cytoplasm G-protein beta/gamma-subunit complex protein-containing complex heterotrimeric G-protein complex plasma membrane cytoplasmic side of plasma membrane membrane extrinsic component of plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane cell periphery side of membrane cytoplasmic side of membrane membrane protein complex plasma membrane protein complex catalytic complex GTPase complex
D [auth N]	Nb35	none	none	none
E [auth R]	Glucagon-like peptide 1 receptor	binding peptide hormone binding amide binding peptide binding hormone binding transmembrane signaling receptor activity signaling receptor activity molecular transducer activity		membrane integral component of membrane intrinsic component of membrane cellular anatomical entity plasma membrane integral component of plasma membrane intrinsic component of plasma membrane cell periphery
F [auth P]	Peptide-19	none	none	none

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, C [auth G], E [auth R]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, C [auth G], E [auth R]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class B1	GLP-1 receptor (GLP-1R) - G_s complex with bound Peptide-19

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.