Annotations: 7L2K

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e7l2kA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7l2kA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth C]	F_UNCLASSIFIED	e7l2kC2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth C]	F_UNCLASSIFIED	e7l2kC1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth D]	F_UNCLASSIFIED	e7l2kD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth D]	F_UNCLASSIFIED	e7l2kD1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e7l2kB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e7l2kB1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth D], D [auth B]	Transient receptor potential cation channel subfamily V member 1	transporter activity ion channel activity cation channel activity calcium channel activity cation transmembrane transporter activity ion transmembrane transporter activity calcium ion transmembrane transporter activity channel activity inorganic molecular entity transmembrane transporter activity passive transmembrane transporter activity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity intracellular ligand-gated ion channel activity ligand-gated ion channel activity calcium-release channel activity ligand-gated channel activity gated channel activity ligand-gated cation channel activity ligand-gated calcium channel activity binding protein binding calmodulin binding channel regulator activity chloride channel regulator activity molecular function regulator activity ion channel regulator activity extracellular ligand-gated ion channel activity excitatory extracellular ligand-gated ion channel activity identical protein binding ion binding cation binding metal ion binding phospholipid binding lipid binding phosphatidylinositol binding phosphoprotein binding temperature-gated ion channel activity transmembrane signaling receptor activity signaling receptor activity molecular transducer activity	response to pH response to abiotic stimulus cellular process response to acidic pH response to stimulus cellular response to stimulus cellular response to abiotic stimulus cellular response to pH cellular response to acidic pH cellular response to environmental stimulus response to endogenous stimulus response to organic substance response to organonitrogen compound response to chemical response to alkaloid cellular response to chemical stimulus cellular response to organic substance cellular response to alkaloid cellular response to organonitrogen compound cellular response to endogenous stimulus response to nitrogen compound cellular response to nitrogen compound response to organic cyclic compound response to purine-containing compound response to ATP response to organophosphorus cellular response to ATP cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound response to cytokine cellular response to cytokine stimulus response to growth factor cellular response to growth factor stimulus response to nerve growth factor cellular response to nerve growth factor stimulus response to temperature stimulus cellular response to temperature stimulus response to tumor necrosis factor cellular response to tumor necrosis factor negative regulation of mitochondrial membrane potential regulation of membrane potential negative regulation of membrane potential regulation of mitochondrial membrane potential biological regulation regulation of biological quality cellular component organization cellular component assembly protein-containing complex organization cellular component biogenesis protein complex oligomerization protein homooligomerization protein tetramerization protein homotetramerization protein-containing complex assembly cellular component organization or biogenesis response to capsazepine response to hormone response to peptide hormone response to peptide	intracellular anatomical structure cytoplasm cytosol cellular anatomical entity dendrite somatodendritic compartment cell projection neuron projection dendritic tree plasma membrane bounded cell projection plasma membrane membrane cell junction cell leading edge cell projection membrane leading edge membrane neuron projection membrane dendrite membrane dendritic spine membrane dendritic spine neuron spine synapse cell periphery synaptic membrane plasma membrane region postsynapse external side of plasma membrane cell surface side of membrane integral component of membrane intrinsic component of membrane integral component of plasma membrane intrinsic component of plasma membrane mitochondrion organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle neuronal cell body cell body postsynaptic membrane

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth C], C [auth D], D [auth B]	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Transient receptor potential channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth C], C [auth D], D [auth B]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth C], C [auth D], D [auth B]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth C], C [auth D], D [auth B]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Transient Receptor Potential (TRP)	TRPV1 transient receptor potential channel, unliganded minimal TRPV1

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.