7L8I

SARS-CoV-2 Main Protease (Mpro) in Complex with Rupintrivir (P21)

Present annotations:

Domain Annotation: ECOD Classification
Gene Product Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e7l8iA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7l8iA2	A: alpha arrays	X: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)	H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)	T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7l8iB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7l8iB2	A: alpha arrays	X: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)	H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)	T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	3C-like proteinase	RNA helicase activity catalytic activity helicase activity ATP-dependent activity, acting on RNA 5'-3' RNA helicase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid ATP-dependent activity endopeptidase activity cysteine-type endopeptidase activity peptidase activity cysteine-type peptidase activity hydrolase activity catalytic activity, acting on a protein DNA helicase activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA nuclease activity endonuclease activity hydrolase activity, acting on ester bonds binding protein binding identical protein binding ubiquitin-like protein-specific protease activity ISG15-specific protease activity mRNA (nucleoside-2'-O-)-methyltransferase activity methyltransferase activity O-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity transferase activity transferase activity, transferring one-carbon groups protein dimerization activity protein homodimerization activity RNA-directed 5'-3' RNA polymerase activity transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity 5'-3' RNA polymerase activity RNA polymerase activity nucleic acid binding RNA binding single-stranded RNA binding organic cyclic compound binding heterocyclic compound binding thiol-dependent deubiquitinase omega peptidase activity deubiquitinase activity zinc ion binding ion binding cation binding metal ion binding transition metal ion binding	viral process viral life cycle viral genome replication positive stranded viral RNA replication viral RNA genome replication response to external stimulus response to biotic stimulus cellular process modulation by virus of host process mitigation of host defenses by virus modulation by virus of host cellular process mitigation of host defenses by symbiont suppression by virus of host NF-kappaB cascade response to external biotic stimulus modulation by symbiont of host process modulation by symbiont of host cellular process biological process involved in symbiotic interaction biological process involved in interspecies interaction between organisms response to stimulus biological process involved in interaction with host response to other organism response to defenses of other organism response to host defenses response to host modulation of process of another organism modulation by virus of host molecular function suppression by virus of host molecular function modulation by virus of host catalytic activity suppression by virus of host TRAF-mediated signal transduction suppression by virus of host TRAF activity modulation of signal transduction in another organism modulation by symbiont of host signal transduction pathway suppression by symbiont of host signal transduction pathway negative regulation by symbiont of host catalytic activity modulation by symbiont of host molecular function modulation by symbiont of host catalytic activity viral gene expression viral protein processing viral transcription	host cellular component host cell cytoplasm host cell part host intracellular part host cell cytoplasm part viral factory cytoplasmic viral factory host intracellular region host cell cellular anatomical entity intracellular anatomical structure cytoplasm cytosol host cell membrane host intracellular organelle host intracellular membrane-bounded organelle double membrane vesicle viral factory host cell cytoplasmic vesicle host cell cytoplasmic vesicle membrane double membrane vesicle viral factory membrane double membrane vesicle viral factory outer membrane host cell endoplasmic reticulum host cell endoplasmic reticulum-Golgi intermediate compartment host cell endosome host cell Golgi apparatus host cell perinuclear region of cytoplasm membrane integral component of membrane intrinsic component of membrane

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.