7RLF

Cryo-EM structure of human p97-E470D mutant bound to ATPgS.

Present annotations:

Domain Annotation: ECOD Classification
Gene Product Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e7rlfA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7rlfA5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7rlfA6	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7rlfA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7rlfB3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7rlfB5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7rlfB6	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7rlfB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7rlfC3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7rlfC5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7rlfC6	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7rlfC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7rlfD3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7rlfD5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7rlfD6	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7rlfD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e7rlfE3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e7rlfE5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e7rlfE6	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e7rlfE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e7rlfF3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e7rlfF5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e7rlfF6	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e7rlfF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E, F A, B, C, D, E, F	Transitional endoplasmic reticulum ATPase	catalytic activity pyrophosphatase activity hydrolase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATP hydrolysis activity nucleoside-triphosphatase activity ATP-dependent activity binding protein-containing complex binding BAT3 complex binding enzyme activator activity peptidase activator activity enzyme regulator activity deubiquitinase activator activity peptidase regulator activity molecular function regulator activity protein binding identical protein binding polyubiquitin modification-dependent protein binding K48-linked polyubiquitin modification-dependent protein binding modification-dependent protein binding lipid binding signaling receptor binding MHC protein binding MHC class I protein binding protein domain specific binding enzyme binding phosphatase binding protein phosphatase binding nucleic acid binding RNA binding organic cyclic compound binding heterocyclic compound binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding	cellular process cellular component organization cellular component assembly cellular component biogenesis inclusion body assembly aggresome assembly cellular component organization or biogenesis metabolic process ATP metabolic process response to inorganic substance response to chemical response to arsenic-containing substance response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to arsenic-containing substance response to oxygen-containing compound cellular response to oxygen-containing compound response to arsenite ion cellular response to arsenite ion positive regulation of mitochondrial membrane potential regulation of membrane potential positive regulation of membrane potential regulation of mitochondrial membrane potential biological regulation regulation of biological quality positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex organization regulation of cellular component biogenesis positive regulation of cellular component biogenesis positive regulation of biological process positive regulation of cellular process regulation of biological process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization protein-containing complex assembly viral process viral life cycle viral genome replication	protein-containing complex catalytic complex ATPase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytoplasmic stress granule ribonucleoprotein granule cytoplasmic ribonucleoprotein granule organelle non-membrane-bounded organelle intracellular organelle intracellular non-membrane-bounded organelle supramolecular complex cytosol endoplasmic reticulum endoplasmic reticulum membrane endomembrane system membrane organelle membrane organelle subcompartment Derlin-1 retrotranslocation complex nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle intracellular membrane-bounded organelle membrane protein complex endoplasmic reticulum subcompartment endoplasmic reticulum protein-containing complex extracellular region extracellular space vesicle extracellular organelle extracellular membrane-bounded organelle extracellular exosome extracellular vesicle secretory granule cytoplasmic vesicle membrane-enclosed lumen organelle lumen intracellular organelle lumen intracellular vesicle secretory vesicle ficolin-1-rich granule ficolin-1-rich granule lumen lipid droplet nucleus nucleoplasm nuclear lumen perinuclear region of cytoplasm vesicle lumen secretory granule lumen cytoplasmic vesicle lumen chromosome site of double-strand break site of DNA damage cell junction synapse VCP-NPL4-UFD1 AAA ATPase complex VCP-NSFL1C complex

RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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190404 Biological Macromolecular Structures Enabling Breakthroughs in Research and Education

7RLF

Cryo-EM structure of human p97-E470D mutant bound to ATPgS.

Present annotations:

Domain Annotation: ECOD Classification ECOD Database Homepage

Gene Product Annotation Gene Product Annotation