7RPK

Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog

Present annotations:

Domain Annotation: SCOP2 Classification
Gene Product Annotation
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth H]	SCOP2B Superfamily	Hedgehog/DD-peptidase	8040401	3001458	SCOP2B (2022-02-25)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein dispatched homolog 1	transporter activity transmembrane transporter activity amide transmembrane transporter activity peptide transmembrane transporter activity
B [auth H]	Sonic hedgehog protein	binding calcium ion binding ion binding cation binding metal ion binding glycosaminoglycan binding carbohydrate derivative binding protein binding laminin binding laminin-1 binding extracellular matrix binding signaling receptor binding patched binding zinc ion binding transition metal ion binding	developmental process anatomical structure development anatomical structure morphogenesis anatomical structure formation involved in morphogenesis animal organ morphogenesis animal organ development animal organ formation cellular process cell differentiation cell development cellular developmental process cell fate commitment cell migration cell motility cell population proliferation response to inorganic substance response to metal ion response to lithium ion response to chemical response to stimulus cellular response to stimulus cellular response to chemical stimulus cellular response to inorganic substance cellular response to metal ion cellular response to lithium ion growth developmental growth epithelial cell proliferation formation of anatomical boundary metabolic process gene expression macromolecule metabolic process organic substance metabolic process mesenchymal cell proliferation myoblast differentiation muscle structure development myotube differentiation muscle cell differentiation striated muscle cell differentiation regulation of cell migration negative regulation of cell migration locomotion regulation of locomotion negative regulation of locomotion negative regulation of biological process negative regulation of cellular process regulation of biological process regulation of cellular process biological regulation regulation of cell motility negative regulation of cell motility negative regulation of metabolic process regulation of gene expression negative regulation of macromolecule metabolic process negative regulation of gene expression regulation of metabolic process regulation of macromolecule metabolic process cell death regulation of cell death negative regulation of cell death neuron death regulation of neuron death negative regulation of neuron death odontogenesis odontogenesis of dentin-containing tooth pancreas development positive regulation of biological process positive regulation of cellular process cell division regulation of cell division positive regulation of cell division positive regulation of cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of gene expression multicellular organismal process neurotrophin production regulation of neurotrophin production positive regulation of neurotrophin production regulation of multicellular organismal process positive regulation of multicellular organismal process striated muscle cell proliferation skeletal muscle cell proliferation regulation of skeletal muscle cell proliferation positive regulation of skeletal muscle cell proliferation muscle cell proliferation regulation of cell differentiation positive regulation of cell differentiation regulation of developmental process positive regulation of developmental process regulation of muscle cell differentiation positive regulation of muscle cell differentiation regulation of striated muscle cell differentiation positive regulation of striated muscle cell differentiation regulation of anatomical structure morphogenesis regulation of odontogenesis regulation of animal organ morphogenesis stem cell proliferation regulation of stem cell proliferation response to organic substance response to ethanol response to alcohol response to oxygen-containing compound roof of mouth development skin development tissue development smooth muscle tissue development muscle tissue development stem cell differentiation stem cell development striated muscle tissue development tracheoesophageal septum formation	axon cell projection neuron projection cellular anatomical entity plasma membrane bounded cell projection cell surface dendrite somatodendritic compartment dendritic tree intracellular anatomical structure cytoplasm endoplasmic reticulum endomembrane system organelle membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle endoplasmic reticulum membrane membrane organelle membrane organelle subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum subcompartment external encapsulating structure extracellular matrix cell periphery extracellular region extracellular space Golgi apparatus membrane raft membrane microdomain neuronal cell body cell body nucleus plasma membrane synaptic vesicle cell junction transport vesicle cytoplasmic vesicle vesicle synapse exocytic vesicle intracellular vesicle presynapse secretory vesicle

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth H]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth H]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth H]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Multi-Drug Efflux Transporters	Dispatched-1 (DISP1) homolog of the Hedgehog (Hh) signaling pathway, 'R' conformation

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.