8AJ8

Structure of p110 gamma bound to the p84 regulatory subunit

Present annotations:

Domain Annotation: SCOP2 Classification
Gene Product Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8040714	3000965	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8040714	3000965	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8040714	3000965	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain calb)	8040714	3000965	SCOP2B (2022-06-29)

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity catalytic activity, acting on a protein protein kinase activity protein serine kinase activity binding phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity catalytic activity, acting on a protein protein kinase activity protein serine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity	cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process glycerolipid metabolic process lipid metabolic process developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development localization import into cell transport endocytosis establishment of localization vesicle-mediated transport chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion immune system process phosphorylation defense response response to stress inflammatory response	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class IB cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class IB extrinsic component of membrane phosphatidylinositol 3-kinase complex, class IA
B, D, F, H	Phosphoinositide 3-kinase regulatory subunit 6	enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity	regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus response to stress regulation of response to stress innate immune response leukocyte mediated immunity regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus response to stress regulation of response to stress innate immune response leukocyte mediated immunity regulation of immune system process response to external biotic stimulus natural killer cell mediated immunity regulation of biological process regulation of natural killer cell mediated immunity response to other organism defense response immune response regulation of innate immune response regulation of leukocyte mediated cytotoxicity biological regulation response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus immune system process defense response to other organism natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing cellular process cell killing cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction positive regulation of phosphorylation regulation of catalytic activity regulation of signal transduction regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity intracellular signal transduction regulation of primary metabolic process cell communication regulation of nitrogen compound metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process signal transduction phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of MAPK cascade cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of response to stimulus positive regulation of molecular function positive regulation of protein modification process organic substance metabolic process regulation of intracellular signal transduction nitrogen compound metabolic process protein metabolic process positive regulation of protein kinase activity positive regulation of cellular process regulation of signaling organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process positive regulation of nitrogen compound metabolic process MAPK cascade regulation of cell communication regulation of phosphorylation positive regulation of signaling developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development regulation of developmental process regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance biosynthetic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process lipid metabolic process G protein-coupled receptor signaling pathway regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation T cell activation cell differentiation positive regulation of leukocyte activation T cell differentiation positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation cellular developmental process cell development positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation regulation of cell-cell adhesion regulation of lymphocyte differentiation hemopoiesis positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation	protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex cellular anatomical entity transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class IB extrinsic component of membrane cell periphery plasma membrane phosphatidylinositol 3-kinase complex, class IA protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex cellular anatomical entity transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class IB extrinsic component of membrane cell periphery plasma membrane phosphatidylinositol 3-kinase complex, class IA intracellular anatomical structure cytoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.