8AJ8 | pdb_00008aj8

Structure of p110 gamma bound to the p84 regulatory subunit

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8040714	3000965	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8040714	3000965	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8040714	3000965	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ARM repeat-like	8038595	3000116	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ubiquitin-like	8034485	3000157	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036673	3000066	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8040714	3000965	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e8aj8A4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e8aj8A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e8aj8A3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e8aj8A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8aj8C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8aj8C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8aj8C4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8aj8C3	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e8aj8E3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e8aj8E2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e8aj8E1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e8aj8E4	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e8aj8G3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e8aj8G1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e8aj8G2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e8aj8G4	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00792	Phosphoinositide 3-kinase C2 (PI3K_C2)	Phosphoinositide 3-kinase C2	Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family.	Domain
A, C, E, G	PF00794	PI3-kinase family, ras-binding domain (PI3K_rbd)	PI3-kinase family, ras-binding domain	Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly significant similarity) to Ras-binding Pfam:PF00788 domains (unpublished observation).	Domain
A, C, E, G	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family
B, D, F, H	PF10486	Phosphoinositide 3-kinase gamma adapter protein p101 subunit (PI3K_1B_p101)	Phosphoinositide 3-kinase gamma adapter protein p101 subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity phosphatidylinositol kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity phosphatidylinositol kinase activity lipid kinase activity 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity histone H2B kinase activity histone H3S57 kinase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process cell migration cell motility chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation intracellular signal transduction cell communication phosphatidylinositol-mediated signaling signal transduction phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction localization import into cell transport endocytosis establishment of localization vesicle-mediated transport immune system process defense response response to stress inflammatory response	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane cell periphery cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane cell periphery plasma membrane phosphatidylinositol 3-kinase complex, class IB
B, D, F, H	Phosphoinositide 3-kinase regulatory subunit 6	enzyme regulator activity phosphatidylinositol kinase activity kinase activity transferase activity 1-phosphatidylinositol-3-kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups lipid kinase activity molecular function regulator activity catalytic activity kinase regulator activity 1-phosphatidylinositol-3-kinase activity	regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus response to stress regulation of response to stress innate immune response leukocyte mediated immunity regulation of immune effector process lymphocyte mediated immunity regulation of defense response regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus response to stress regulation of response to stress innate immune response leukocyte mediated immunity regulation of immune system process response to external biotic stimulus natural killer cell mediated immunity regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism defense response regulation of innate immune response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus immune system process defense response to other organism natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing cellular process cell killing cellular response to stimulus signaling G protein-coupled receptor signaling pathway signal transduction cell communication positive regulation of cell communication positive regulation of signal transduction positive regulation of phosphorylation regulation of catalytic activity regulation of signal transduction regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity intracellular signal transduction regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of MAPK cascade regulation of protein metabolic process primary metabolic process positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of response to stimulus positive regulation of molecular function positive regulation of protein modification process regulation of intracellular signal transduction protein metabolic process positive regulation of protein kinase activity positive regulation of cellular process regulation of signaling positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process MAPK cascade regulation of cell communication regulation of phosphorylation positive regulation of signaling developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development regulation of developmental process regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation T cell activation cell differentiation positive regulation of leukocyte activation T cell differentiation positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation cellular developmental process cell development positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation regulation of cell-cell adhesion regulation of lymphocyte differentiation hemopoiesis positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation	cell periphery cellular anatomical structure plasma membrane membrane protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class IB extrinsic component of membrane intracellular anatomical structure cell periphery cellular anatomical structure plasma membrane membrane protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class IB extrinsic component of membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR015433	Phosphatidylinositol kinase	Family
A, C, E, G	IPR016024	Armadillo-type fold	Homologous Superfamily
A, C, E, G	IPR002420	C2 phosphatidylinositol 3-kinase-type domain	Domain
A, C, E, G	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A, C, E, G	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A, C, E, G	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	Domain
A, C, E, G	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Homologous Superfamily
A, C, E, G	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A, C, E, G	IPR003113	Phosphatidylinositol 3-kinase, adaptor-binding domain	Domain
A, C, E, G	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, C, E, G	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Domain
A, C, E, G	IPR035892	C2 domain superfamily	Homologous Superfamily
A, C, E, G	IPR045580	PIK3 catalytic subunit gamma, adaptor-binding domain	Domain
A, C, E, G	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B, D, F, H	IPR019522	Phosphoinositide 3-kinase regulatory subunit 5/6	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.