8E74

Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor

Present annotations:

Gene Product Annotation

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth Z]	Transcription termination/antitermination protein NusG		negative regulation of termination of DNA-templated transcription regulation of cellular process negative regulation of biological process negative regulation of nitrogen compound metabolic process protein-containing complex disassembly positive regulation of macromolecule biosynthetic process regulation of protein-containing complex disassembly cellular nitrogen compound biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process regulation of nitrogen compound metabolic process positive regulation of metabolic process DNA-templated transcription negative regulation of termination of DNA-templated transcription regulation of cellular process negative regulation of biological process negative regulation of nitrogen compound metabolic process protein-containing complex disassembly positive regulation of macromolecule biosynthetic process regulation of protein-containing complex disassembly cellular nitrogen compound biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process regulation of nitrogen compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process heterocycle metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process cellular component disassembly negative regulation of DNA-templated transcription regulation of biological process negative regulation of cellular component organization cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process negative regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process aromatic compound biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of termination of DNA-templated transcription regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of cellular component organization transcription antitermination cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process DNA-templated transcription termination RNA biosynthetic process cellular component organization organic substance metabolic process positive regulation of biosynthetic process negative regulation of protein-containing complex disassembly negative regulation of cellular process nitrogen compound metabolic process cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process protein-containing complex organization biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process heterocycle biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression negative regulation of biosynthetic process cellular process positive regulation of cellular biosynthetic process cellular aromatic compound metabolic process regulation of DNA-templated transcription elongation DNA-templated transcription elongation transcription elongation by RNA polymerase II protein-DNA complex organization transcription by RNA polymerase II chromatin organization chromatin remodeling transcription elongation-coupled chromatin remodeling
B [auth A], C [auth B]	DNA-directed RNA polymerase subunit alpha	DNA binding binding organic cyclic compound binding nucleic acid binding heterocyclic compound binding protein binding protein dimerization activity DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding binding organic cyclic compound binding nucleic acid binding heterocyclic compound binding protein binding protein dimerization activity DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process heterocycle biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process aromatic compound biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process cellular aromatic compound metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
D [auth C]	DNA-directed RNA polymerase subunit beta	DNA binding binding organic cyclic compound binding nucleic acid binding heterocyclic compound binding DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding heterocyclic compound binding DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups ribonucleoside binding nucleoside binding carbohydrate derivative binding small molecule binding	cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process heterocycle biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process aromatic compound biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process cellular aromatic compound metabolic process	transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
E [auth D]	DNA-directed RNA polymerase subunit beta'	cation binding magnesium ion binding ion binding binding metal ion binding DNA binding organic cyclic compound binding nucleic acid binding heterocyclic compound binding DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity cation binding magnesium ion binding ion binding binding metal ion binding DNA binding organic cyclic compound binding nucleic acid binding heterocyclic compound binding DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups transition metal ion binding zinc ion binding	cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process heterocycle biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process aromatic compound biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process cellular aromatic compound metabolic process	transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
F [auth E]	DNA-directed RNA polymerase subunit omega	DNA binding binding organic cyclic compound binding nucleic acid binding heterocyclic compound binding DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process cellular biosynthetic process RNA metabolic process cellular nitrogen compound biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic substance metabolic process heterocycle metabolic process organic substance biosynthetic process nitrogen compound metabolic process cellular metabolic process cellular nitrogen compound metabolic process primary metabolic process nucleobase-containing compound biosynthetic process heterocycle biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process aromatic compound biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process cellular aromatic compound metabolic process	transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
G [auth O]	DNA (54-MER)	none	none	none
H [auth P]	DNA (54-MER)	none	none	none
I [auth R]	RNA (42-MER)	none	none	none

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.