8FE1

Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State

Present annotations:

Gene Product Annotation
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Gene Product Annotation Gene Product Annotation

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C, D [auth B]	Glycine receptor subunit alphaZ1	ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion gated channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity salt transmembrane transporter activity inhibitory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion gated channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity salt transmembrane transporter activity inhibitory extracellular ligand-gated monoatomic ion channel activity extracellularly glycine-gated ion channel activity inorganic molecular entity transmembrane transporter activity extracellularly glycine-gated chloride channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic anion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic anion channel activity inorganic anion transmembrane transporter activity chloride channel activity cation binding ion binding binding organic acid binding anion binding glycine binding amino acid binding carboxylic acid binding small molecule binding transmitter-gated monoatomic ion channel activity molecular transducer activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential transmitter-gated channel activity transition metal ion binding zinc ion binding metal ion binding transmembrane signaling receptor activity	response to acid chemical response to organic substance response to stimulus response to chemical response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cell communication response to acid chemical response to organic substance response to stimulus response to chemical response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway trans-synaptic signaling cell-cell signaling synaptic transmission, glycinergic chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport regulation of developmental process cellular developmental process regulation of cell differentiation generation of neurons neurogenesis neuron differentiation cell differentiation regulation of neuron differentiation cellular response to nitrogen compound cellular response to acid chemical cellular response to amino acid stimulus response to endogenous stimulus cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to organic substance response to alcohol cellular response to alcohol cellular response to ethanol response to ethanol cellular response to inorganic substance cellular response to metal ion response to zinc ion response to inorganic substance response to metal ion cellular response to zinc ion	protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex cell periphery postsynapse postsynaptic membrane synapse cell junction plasma membrane protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex cellular anatomical entity transporter complex monoatomic ion channel complex cell periphery postsynapse postsynaptic membrane synapse cell junction plasma membrane plasma membrane region synaptic membrane somatodendritic compartment cell body perikaryon neuronal cell body cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection
E	Glycine receptor beta subunit 2	transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion gated channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity salt transmembrane transporter activity inhibitory extracellular ligand-gated monoatomic ion channel activity extracellularly glycine-gated ion channel activity inorganic molecular entity transmembrane transporter activity extracellularly glycine-gated chloride channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic anion channel activity monoatomic anion channel activity inorganic anion transmembrane transporter activity chloride channel activity transmembrane signaling receptor activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway trans-synaptic signaling cell-cell signaling synaptic transmission, glycinergic cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway trans-synaptic signaling cell-cell signaling synaptic transmission, glycinergic chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling protein localization localization cellular localization cellular macromolecule localization macromolecule localization transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane cell projection neuron projection plasma membrane bounded cell projection

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth D], C, D [auth B], E	OPM	Transmembrane	Alpha-helical polytopic	Pentameric ligand-gated ion channels	Ligand-gated ion channel of neurotransmitter receptors

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth D], C, D [auth B], E	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.