8FE1 | pdb_00008fe1

Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e8fe1A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e8fe1A1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth D]	F_UNCLASSIFIED	e8fe1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth D]	F_UNCLASSIFIED	e8fe1D2	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8fe1C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e8fe1C2	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e8fe1B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e8fe1B2	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e8fe1E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e8fe1E1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C, D [auth B]	PF02932	Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb)	Neurotransmitter-gated ion-channel transmembrane region	-	Family
A, B [auth D], C, D [auth B]	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family
E	PF02932	Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb)	Neurotransmitter-gated ion-channel transmembrane region	-	Family
E	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C, D [auth B]	Glycine receptor subunit alphaZ1	transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity transmitter-gated channel activity monoatomic ion transmembrane transporter activity transporter activity transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity transmitter-gated channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity inhibitory extracellular ligand-gated monoatomic ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic anion channel activity extracellularly glycine-gated ion channel activity inorganic molecular entity transmembrane transporter activity monoatomic anion channel activity extracellularly glycine-gated chloride channel activity inorganic anion transmembrane transporter activity chloride channel activity cation binding organic acid binding binding ion binding anion binding glycine binding amino acid binding carboxylic acid binding small molecule binding transition metal ion binding zinc ion binding metal ion binding transmembrane signaling receptor activity	response to acid chemical response to stimulus response to chemical response to amino acid developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development transport monoatomic ion transmembrane transport inorganic ion transmembrane transport response to acid chemical response to stimulus response to chemical response to amino acid developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation regulation of cell differentiation generation of neurons neurogenesis neuron differentiation cell differentiation regulation of neuron differentiation cellular response to acid chemical cellular response to stimulus cellular response to amino acid stimulus cellular response to chemical stimulus response to alcohol response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to alcohol cellular response to ethanol response to ethanol cellular response to metal ion response to metal ion response to zinc ion cellular response to zinc ion	protein-containing complex cellular anatomical structure transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex cell periphery postsynapse postsynaptic membrane synapse cell junction plasma membrane protein-containing complex cellular anatomical structure transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex cell periphery postsynapse postsynaptic membrane synapse cell junction plasma membrane plasma membrane region synaptic membrane somatodendritic compartment cell body perikaryon neuronal cell body cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection
E	Glycine receptor beta subunit 2	monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity extracellularly glycine-gated ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity inhibitory extracellular ligand-gated monoatomic ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity extracellularly glycine-gated ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion channel activity transporter activity extracellularly glycine-gated chloride channel activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C, D [auth B]	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B [auth D], C, D [auth B]	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, B [auth D], C, D [auth B]	IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha	Family
A, B [auth D], C, D [auth B]	IPR008127	Glycine receptor alpha	Family
A, B [auth D], C, D [auth B]	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, B [auth D], C, D [auth B]	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B [auth D], C, D [auth B]	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, B [auth D], C, D [auth B]	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, B [auth D], C, D [auth B]	IPR008128	Glycine receptor alpha1	Family
A, B [auth D], C, D [auth B]	IPR006201	Neurotransmitter-gated ion-channel	Family
E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
E	IPR008060	Glycine receptor beta	Family
E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
E	IPR047029	Glycine receptor subunit beta, transmembrane domain	Domain
E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
E	IPR006201	Neurotransmitter-gated ion-channel	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth D], C, D [auth B], E	OPM	Transmembrane	Alpha-helical polytopic	Pentameric ligand-gated ion channels	Ligand-gated ion channel of neurotransmitter receptors

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth D], C, D [auth B], E	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth D], C, D [auth B], E	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Cys-Loop Receptor Family	α1β_Bheteromeric Glycine Receptor, strychnine-bound state

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.