8Q6J

Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ESCOP2B SuperfamilyGrowth factor receptor domain-like 8043692 3000398 SCOP2B (2021-05-27)
ESCOP2B SuperfamilyL domain-like 8043690 3001010 SCOP2B (2021-05-27)
ESCOP2B SuperfamilyL domain-like 8043691 3001010 SCOP2B (2021-05-27)
ESCOP2B SuperfamilyGrowth factor receptor domain-like 8043694 3000398 SCOP2B (2021-05-27)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF07654e8q6jA2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
APF07686e8q6jA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)
BPF07654e8q6jB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
BPF07686e8q6jB2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)
CPF07654e8q6jC1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
CPF07686e8q6jC2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)
DPF07654e8q6jD1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
DPF07686e8q6jD2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
Light ChainIGKV1 Kappareceptor tyrosine-protein kinase erbb-2SAbDab (2024-07-12)
Heavy ChainIGHV3 -receptor tyrosine-protein kinase erbb-2SAbDab (2024-07-12)
Light ChainIGKV1 Kappareceptor tyrosine-protein kinase erbb-2SAbDab (2024-07-12)
Heavy ChainIGHV3 -receptor tyrosine-protein kinase erbb-2SAbDab (2024-07-12)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
Coprelotamab ERBB2/CD340/HER2, CD3E, ERBB2/CD340/HER2 (Domain II), ERBB2/CD340/HER2 (Domain IV), SIRPATherapeutic SAbDab (2024-07-12)
Timigutuzumab ERBB2/CD340/HER2, SIRPA, CD3ETherapeutic SAbDab (2024-07-12)
Pertuzumab ERBB2/CD340/HER2Therapeutic SAbDab (2024-07-12)
Anbenitamab ERBB2/CD340/HER2 (Domain II), ERBB2/CD340/HER2 (Domain IV), ERBB2/CD340/HER2Therapeutic SAbDab (2024-07-12)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00757Furin-like cysteine rich region (Furin-like)Furin-like cysteine rich region- Domain
PF01030Receptor L domain (Recep_L_domain)Receptor L domain- Repeat
PF14843Growth factor receptor domain IV (GF_recep_IV)Growth factor receptor domain IVThis is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Trastuzumab fab light chain---
Trastuzumab Fab heavy chain---
Pertuzumab Fab light chain---
Pertuzumab Fab heavy chain---
Receptor tyrosine-protein kinase erbB-2