Chemical Component Summary

Nameresiniferatoxin
SynonymsRTX
Identifiersn/a
FormulaC37 H40 O9
Molecular Weight628.71
TypeNON-POLYMER
Isomeric SMILESC[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)Cc6ccc(c(c6)OC)O)O)C)O[C@](O3)(O2)Cc7ccccc7)C(=C)C
InChIInChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1
InChIKeyDSDNAKHZNJAGHN-MXTYGGKSSA-N

Chemical Details

Formal Charge0
Atom Count86
Chiral Atom Count8
Bond Count92
Aromatic Bond Count12

Drug Info: DrugBank

DrugBank IDDB06515 
NameResiniferatoxin
Groupsinvestigational
DescriptionResiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).
Synonyms
  • RTX
  • Resiniferatoxin
IndicationInvestigated for use/treatment in interstitial cystitis and urinary incontinence.
Categories
  • Neurotoxins
  • Terpenes
  • TRPV Cation Channels
CAS number57444-62-9

Drug Targets

NameTarget SequencePharmacological ActionActions
Transient receptor potential cation channel subfamily V member 1MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem5702546
ChEMBLCHEMBL17976