6EU

resiniferatoxin

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is present as a standalone ligand in 28 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries

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Chemical Component Summary
Name	resiniferatoxin
Synonyms	RTX
Identifiers	n/a
Formula	C₃₇ H₄₀ O₉
Molecular Weight	628.71
Type	NON-POLYMER
Isomeric SMILES	C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)Cc6ccc(c(c6)OC)O)O)C)O[C@](O3)(O2)Cc7ccccc7)C(=C)C
InChI	InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1
InChIKey	DSDNAKHZNJAGHN-MXTYGGKSSA-N

Chemical Details
Formal Charge	0
Atom Count	86
Chiral Atom Count	8
Bond Count	92
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB06515
Name	Resiniferatoxin
Groups	investigational
Description	Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).
Synonyms	Resiniferatoxin RTX
Indication	Investigated for use/treatment in interstitial cystitis and urinary incontinence.
Categories	Neurotoxins Terpenes
CAS number	57444-62-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682