6EU
resiniferatoxin
Find entries where: 6EU
is present as a standalone ligand in 28 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries
Chemical Component Summary | |
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Name | resiniferatoxin |
Synonyms | RTX |
Identifiers | n/a |
Formula | C37 H40 O9 |
Molecular Weight | 628.71 |
Type | NON-POLYMER |
Isomeric SMILES | C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)Cc6ccc(c(c6)OC)O)O)C)O[C@](O3)(O2)Cc7ccccc7)C(=C)C |
InChI | InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1 |
InChIKey | DSDNAKHZNJAGHN-MXTYGGKSSA-N |
Chemical Details | |
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Formal Charge | 0 |
Atom Count | 86 |
Chiral Atom Count | 8 |
Bond Count | 92 |
Aromatic Bond Count | 12 |
Drug Info: DrugBank
DrugBank ID | DB06515 |
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Name | Resiniferatoxin |
Groups | investigational |
Description | Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain). |
Synonyms |
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Indication | Investigated for use/treatment in interstitial cystitis and urinary incontinence. |
Categories |
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CAS number | 57444-62-9 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
---|---|---|---|
Transient receptor potential cation channel subfamily V member 1 | MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
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PubChem | 5702546 |
ChEMBL | CHEMBL17976 |