PRO
PROLINE
Find entries where: PRO
is present as a standalone ligand in 162 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 33 entries
is present in a polymer sequence 217,023 entries
Chemical Component Summary | |
---|---|
Name | PROLINE |
Identifiers | (2S)-pyrrolidine-2-carboxylic acid |
Formula | C5 H9 N O2 |
Molecular Weight | 115.13 |
Type | L-PEPTIDE LINKING |
Isomeric SMILES | C1C[C@H](NC1)C(=O)O |
InChI | InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 |
InChIKey | ONIBWKKTOPOVIA-BYPYZUCNSA-N |
Chemical Details | |
---|---|
Formal Charge | 0 |
Atom Count | 17 |
Chiral Atom Count | 1 |
Bond Count | 17 |
Aromatic Bond Count | 0 |
Drug Info: DrugBank
DrugBank ID | DB00172 |
---|---|
Name | Proline |
Groups | nutraceutical |
Description | Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. |
Synonyms |
|
Brand Names |
|
Indication | L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles. |
Categories |
|
CAS number | 147-85-3 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
---|---|---|---|
Pyrroline-5-carboxylate reductase 1, mitochondrial | MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGV... | unknown | |
Bifunctional glutamate/proline--tRNA ligase | MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTD... | unknown | |
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMI... | unknown | |
Sodium-dependent proline transporter | MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSC... | unknown | |
Pyrroline-5-carboxylate reductase 2 | MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGV... | unknown | |
View More |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
---|---|
PubChem | 6971047, 145742 |
ChEMBL | CHEMBL54922 |
ChEBI | CHEBI:17203, CHEBI:60039 |
CCDC/CSD | HUDRAC |