PRO

PROLINE



Chemical Component Summary

NamePROLINE
Identifiers(2S)-pyrrolidine-2-carboxylic acid
FormulaC5 H9 N O2
Molecular Weight115.13
TypeL-PEPTIDE LINKING
Isomeric SMILESC1C[C@H](NC1)C(=O)O
InChIInChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKeyONIBWKKTOPOVIA-BYPYZUCNSA-N

Chemical Details

Formal Charge0
Atom Count17
Chiral Atom Count1
Bond Count17
Aromatic Bond Count0

Drug Info: DrugBank

DrugBank IDDB00172 
NameProline
Groups nutraceutical
DescriptionProline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.
Synonyms
  • (−)-proline
  • L-Prolin
  • 2-Pyrrolidinecarboxylic acid
  • L-alpha-pyrrolidinecarboxylic acid
  • L-(−)-proline
Brand Names
  • 2.75% Travas. Amino Acid InJ.W.elecw.25%dex
  • Smofkabiven Extra Nitrogen
  • 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose
  • 8.5% Freamine III
  • 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix
IndicationL-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.
Categories
  • Amino Acids
  • Amino Acids, Cyclic
  • Amino Acids, Peptides, and Proteins
  • Dietary Supplements
  • Imino Acids
CAS number147-85-3

Drug Targets

NameTarget SequencePharmacological ActionActions
Pyrroline-5-carboxylate reductase 1, mitochondrialMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGV...unknown
Bifunctional glutamate/proline--tRNA ligaseMATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTD...unknown
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMI...unknown
Sodium-dependent proline transporterMKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSC...unknown
Pyrroline-5-carboxylate reductase 2MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGV...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 6971047, 145742
ChEMBL CHEMBL54922
ChEBI CHEBI:17203, CHEBI:60039
CCDC/CSD HUDRAC