TYR
TYROSINE
Find entries where: TYR
is present as a standalone ligand in 77 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 23 entries
is present in a polymer sequence 216,106 entries
Chemical Component Summary | |
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Name | TYROSINE |
Identifiers | (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid |
Formula | C9 H11 N O3 |
Molecular Weight | 181.189 |
Type | L-PEPTIDE LINKING |
Isomeric SMILES | c1cc(ccc1C[C@@H](C(=O)O)N)O |
InChI | InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 |
InChIKey | OUYCCCASQSFEME-QMMMGPOBSA-N |
Chemical Details | |
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Formal Charge | 0 |
Atom Count | 24 |
Chiral Atom Count | 1 |
Bond Count | 24 |
Aromatic Bond Count | 6 |
Drug Info: DrugBank
DrugBank ID | DB00135 |
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Name | Tyrosine |
Groups |
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Description | Tyrosine is a non-essential amino acid. In animals it is synthesized from [phenylalanine]. It is also the precursor of [epinephrine], thyroid hormones, and melanin. |
Synonyms |
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Brand Names |
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Indication | Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies. |
Categories |
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CAS number | 60-18-4 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
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Tyrosine 3-monooxygenase | MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTA... | unknown | binder |
Tyrosine--tRNA ligase, mitochondrial | MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKD... | unknown | |
Tyrosine--tRNA ligase, cytoplasmic | MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHV... | unknown | |
Tyrosine aminotransferase | MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK... | unknown | |
Monocarboxylate transporter 8 | MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE... | unknown | inhibitor |
View More |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
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PubChem | 6057, 6942100 |
ChEMBL | CHEMBL925 |
ChEBI | CHEBI:58315, CHEBI:17895 |
CCDC/CSD | FAZHET01, SEDDEM, DLTYRS, GUQCEC, RODSUA, LTYRHC10, ILUSUF, FAPLIS |