Mechanism-based design of a protein kinase inhibitor.
Parang, K., Till, J.H., Ablooglu, A.J., Kohanski, R.A., Hubbard, S.R., Cole, P.A.(2001) Nat Struct Biol 8: 37-41
- PubMed: 11135668 
- DOI: 10.1038/83028
- Primary Citation of Related Structures:  
1GAG - PubMed Abstract: 
Protein kinase inhibitors have applications as anticancer therapeutic agents and biological tools in cell signaling. Based on a phosphoryl transfer mechanism involving a dissociative transition state, a potent and selective bisubstrate inhibitor for the insulin receptor tyrosine kinase was synthesized by linking ATPgammaS to a peptide substrate analog via a two-carbon spacer ...