Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.Wolfe, S.A., Grant, R.A., Elrod-Erickson, M., Pabo, C.O.
(2001) Structure 9: 717-723
- PubMed: 11587646
- DOI: https://doi.org/10.1016/s0969-2126(01)00632-3
- Primary Citation of Related Structures:
- PubMed Abstract:
Several methods have been developed for creating Cys2His2 zinc finger proteins that recognize novel DNA sequences, and these proteins may have important applications in biological research and gene therapy. In spite of this progress with design/selection methodology, fundamental questions remain about the principles that govern DNA recognition. One hypothesis suggests that recognition can be described by a simple set of rules--essentially a "recognition code"--but careful assessment of this proposal has been difficult because there have been few structural studies of selected zinc finger proteins.
Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.