6R5Q

Structure of XBP1u-paused ribosome nascent chain complex (post-state)


Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 3.00 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 1.1 of the entry. See complete history


Literature

Structural and mutational analysis of the ribosome-arresting human XBP1u.

Shanmuganathan, V.Schiller, N.Magoulopoulou, A.Cheng, J.Braunger, K.Cymer, F.Berninghausen, O.Beatrix, B.Kohno, K.Heijne, G.V.Beckmann, R.

(2019) Elife 8

  • DOI: 10.7554/eLife.46267
  • Primary Citation of Related Structures:  
    6R5Q, 6R6P, 6R6G, 6R7Q

  • PubMed Abstract: 
  • XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the ribosomal exit tunnel proximal to the peptidyl transferase center where it causes a subtle distortion, thereby explaining the temporary translational arrest induced by XBP1u ...

    XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the ribosomal exit tunnel proximal to the peptidyl transferase center where it causes a subtle distortion, thereby explaining the temporary translational arrest induced by XBP1u. During ribosomal pausing the hydrophobic region 2 (HR2) of XBP1u is recognized by SRP, but fails to efficiently gate the Sec61 translocon. An exhaustive mutagenesis scan of the XBP1u AP revealed that only 8 out of 20 mutagenized positions are optimal; in the remaining 12 positions, we identify 55 different mutations increase the level of translational arrest. Thus, the wildtype XBP1u AP induces only an intermediate level of translational arrest, allowing efficient targeting by SRP without activating the Sec61 channel.


    Organizational Affiliation

    Gene Center, Department of Biochemistry, Center for integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Munich, Germany.



Macromolecules

Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 2
MoleculeChainsSequence LengthOrganismDetailsImage
X-box-binding protein 1B [auth 1]24Homo sapiensMutation(s): 0 
Gene Names: XBP1TREB5XBP2
Find proteins for P17861 (Homo sapiens)
Explore P17861 
Go to UniProtKB:  P17861
NIH Common Fund Data Resources
PHAROS:  P17861
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 7
MoleculeChainsSequence LengthOrganismDetailsImage
uL2G [auth A]248Oryctolagus cuniculusMutation(s): 0 
Gene Names: ZNF34
Find proteins for G1TT27 (Oryctolagus cuniculus)
Explore G1TT27 
Go to UniProtKB:  G1TT27
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 8
MoleculeChainsSequence LengthOrganismDetailsImage
uL3H [auth B]394Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPL3
Find proteins for G1TL06 (Oryctolagus cuniculus)
Explore G1TL06 
Go to UniProtKB:  G1TL06
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 9
MoleculeChainsSequence LengthOrganismDetailsImage
uL4I [auth C]362Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SVW5 (Oryctolagus cuniculus)
Explore G1SVW5 
Go to UniProtKB:  G1SVW5
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 10
MoleculeChainsSequence LengthOrganismDetailsImage
60S ribosomal protein L5J [auth D]293Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SYJ6 (Oryctolagus cuniculus)
Explore G1SYJ6 
Go to UniProtKB:  G1SYJ6
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 11
MoleculeChainsSequence LengthOrganismDetailsImage
60S ribosomal protein L6K [auth E]251Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SKF7 (Oryctolagus cuniculus)
Explore G1SKF7 
Go to UniProtKB:  G1SKF7
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 12
MoleculeChainsSequence LengthOrganismDetailsImage
uL30L [auth F]225Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SV32 (Oryctolagus cuniculus)
Explore G1SV32 
Go to UniProtKB:  G1SV32
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 13
MoleculeChainsSequence LengthOrganismDetailsImage
eL8M [auth G]233Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1STW0 (Oryctolagus cuniculus)
Explore G1STW0 
Go to UniProtKB:  G1STW0
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 14
MoleculeChainsSequence LengthOrganismDetailsImage
uL6N [auth H]190Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SWI6 (Oryctolagus cuniculus)
Explore G1SWI6 
Go to UniProtKB:  G1SWI6
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 15
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein L10 (Predicted)O [auth I]205Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPL10
Find proteins for B7NZQ2 (Oryctolagus cuniculus)
Explore B7NZQ2 
Go to UniProtKB:  B7NZQ2
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 16
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein L11P [auth J]170Oryctolagus cuniculusMutation(s): 0 
Gene Names: ELOA
Find proteins for G1TUB8 (Oryctolagus cuniculus)
Explore G1TUB8 
Go to UniProtKB:  G1TUB8
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 17
MoleculeChainsSequence LengthOrganismDetailsImage
60S ribosomal protein L13Q [auth L]210Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TPV0 (Oryctolagus cuniculus)
Explore G1TPV0 
Go to UniProtKB:  G1TPV0
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 18
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein L14R [auth M]138Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPL14
Find proteins for U3KNW6 (Oryctolagus cuniculus)
Explore U3KNW6 
Go to UniProtKB:  U3KNW6
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 19
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein L15S [auth N]203Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1T0C1 (Oryctolagus cuniculus)
Explore G1T0C1 
Go to UniProtKB:  G1T0C1
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 20
MoleculeChainsSequence LengthOrganismDetailsImage
uL13T [auth O]199Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 21
MoleculeChainsSequence LengthOrganismDetailsImage
uL22U [auth P]153Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SCJ6 (Oryctolagus cuniculus)
Explore G1SCJ6 
Go to UniProtKB:  G1SCJ6
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 22
MoleculeChainsSequence LengthOrganismDetailsImage
eL18V [auth Q]187Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TX70 (Oryctolagus cuniculus)
Explore G1TX70 
Go to UniProtKB:  G1TX70
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 23
MoleculeChainsSequence LengthOrganismDetailsImage
eL19W [auth R]180Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 24
MoleculeChainsSequence LengthOrganismDetailsImage
eL20X [auth S]176Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 25
MoleculeChainsSequence LengthOrganismDetailsImage
eL21Y [auth T]159Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPL21
Find proteins for G1SHQ2 (Oryctolagus cuniculus)
Explore G1SHQ2 
Go to UniProtKB:  G1SHQ2
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 26
MoleculeChainsSequence LengthOrganismDetailsImage
eL22Z [auth U]99Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 27
MoleculeChainsSequence LengthOrganismDetailsImage
eL14AA [auth V]131Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1T6D1 (Oryctolagus cuniculus)
Explore G1T6D1 
Go to UniProtKB:  G1T6D1
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 28
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein L24BA [auth W]121Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPL24
Find proteins for G1SE28 (Oryctolagus cuniculus)
Explore G1SE28 
Go to UniProtKB:  G1SE28
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 29
MoleculeChainsSequence LengthOrganismDetailsImage
uL23CA [auth X]118Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SE76 (Oryctolagus cuniculus)
Explore G1SE76 
Go to UniProtKB:  G1SE76
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 30
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein L26DA [auth Y]134Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPL26
Find proteins for G1SQH0 (Oryctolagus cuniculus)
Explore G1SQH0 
Go to UniProtKB:  G1SQH0
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 31
MoleculeChainsSequence LengthOrganismDetailsImage
60S ribosomal protein L27EA [auth Z]135Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPL27
Find proteins for G1TXF6 (Oryctolagus cuniculus)
Explore G1TXF6 
Go to UniProtKB:  G1TXF6
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 32
MoleculeChainsSequence LengthOrganismDetailsImage
uL15FA [auth a]147Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SNY0 (Oryctolagus cuniculus)
Explore G1SNY0 
Go to UniProtKB:  G1SNY0
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 33
MoleculeChainsSequence LengthOrganismDetailsImage
eL29GA [auth b]104Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SGR6 (Oryctolagus cuniculus)
Explore G1SGR6 
Go to UniProtKB:  G1SGR6
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 34
MoleculeChainsSequence LengthOrganismDetailsImage
eL30HA [auth c]98Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TDL2 (Oryctolagus cuniculus)
Explore G1TDL2 
Go to UniProtKB:  G1TDL2
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 35
MoleculeChainsSequence LengthOrganismDetailsImage
eL31IA [auth d]107Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SHG0 (Oryctolagus cuniculus)
Explore G1SHG0 
Go to UniProtKB:  G1SHG0
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 36
MoleculeChainsSequence LengthOrganismDetailsImage
eL32JA [auth e]128Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TUN8 (Oryctolagus cuniculus)
Explore G1TUN8 
Go to UniProtKB:  G1TUN8
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 37
MoleculeChainsSequence LengthOrganismDetailsImage
eL33KA [auth f]109Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SF08 (Oryctolagus cuniculus)
Explore G1SF08 
Go to UniProtKB:  G1SF08
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 38
MoleculeChainsSequence LengthOrganismDetailsImage
eL34LA [auth g]114Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1U945 (Oryctolagus cuniculus)
Explore G1U945 
Go to UniProtKB:  G1U945
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 39
MoleculeChainsSequence LengthOrganismDetailsImage
uL29MA [auth h]122Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SIT5 (Oryctolagus cuniculus)
Explore G1SIT5 
Go to UniProtKB:  G1SIT5
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 40
MoleculeChainsSequence LengthOrganismDetailsImage
60S ribosomal protein L36NA [auth i]102Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TTQ5 (Oryctolagus cuniculus)
Explore G1TTQ5 
Go to UniProtKB:  G1TTQ5
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 41
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein L37OA [auth j]86Oryctolagus cuniculusMutation(s): 0 
Find proteins for U3KPD5 (Oryctolagus cuniculus)
Explore U3KPD5 
Go to UniProtKB:  U3KPD5
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 42
MoleculeChainsSequence LengthOrganismDetailsImage
eL38PA [auth k]69Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 43
MoleculeChainsSequence LengthOrganismDetailsImage
eL39QA [auth l]50Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TTN1 (Oryctolagus cuniculus)
Explore G1TTN1 
Go to UniProtKB:  G1TTN1
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 44
MoleculeChainsSequence LengthOrganismDetailsImage
eL40RA [auth m]52Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 45
MoleculeChainsSequence LengthOrganismDetailsImage
60s ribosomal protein l41SA [auth n]25Oryctolagus cuniculusMutation(s): 0 
Find proteins for A0A087WNH4 (Oryctolagus cuniculus)
Explore A0A087WNH4 
Go to UniProtKB:  A0A087WNH4
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 46
MoleculeChainsSequence LengthOrganismDetailsImage
eL42TA [auth o]104Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1T040 (Oryctolagus cuniculus)
Explore G1T040 
Go to UniProtKB:  G1T040
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 47
MoleculeChainsSequence LengthOrganismDetailsImage
ribosomal protein eL43UA [auth p]91Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SY53 (Oryctolagus cuniculus)
Explore G1SY53 
Go to UniProtKB:  G1SY53
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 48
MoleculeChainsSequence LengthOrganismDetailsImage
eL28VA [auth r]124Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1U7L1 (Oryctolagus cuniculus)
Explore G1U7L1 
Go to UniProtKB:  G1U7L1
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 49
MoleculeChainsSequence LengthOrganismDetailsImage
60S acidic ribosomal protein P0WA [auth s]196Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 50
MoleculeChainsSequence LengthOrganismDetailsImage
uL11XA [auth t]153Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SMR7 (Oryctolagus cuniculus)
Explore G1SMR7 
Go to UniProtKB:  G1SMR7
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 52
MoleculeChainsSequence LengthOrganismDetailsImage
uS2ZA [auth q]217Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 53
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S3aAB [auth u]213Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPS3A
Find proteins for G1SS70 (Oryctolagus cuniculus)
Explore G1SS70 
Go to UniProtKB:  G1SS70
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 54
MoleculeChainsSequence LengthOrganismDetailsImage
uS5BB [auth v]221Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 55
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S3CB [auth w]228Oryctolagus cuniculusMutation(s): 0 
EC: 4.2.99.18
Find proteins for G1TNM3 (Oryctolagus cuniculus)
Explore G1TNM3 
Go to UniProtKB:  G1TNM3
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 56
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S4DB [auth x]262Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TK17 (Oryctolagus cuniculus)
Explore G1TK17 
Go to UniProtKB:  G1TK17
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 57
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S5EB [auth y]191Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPS5
Find proteins for G1TFM5 (Oryctolagus cuniculus)
Explore G1TFM5 
Go to UniProtKB:  G1TFM5
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 58
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S6FB [auth z]237Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TM55 (Oryctolagus cuniculus)
Explore G1TM55 
Go to UniProtKB:  G1TM55
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 59
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S7GB [auth BB]189Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SVB0 (Oryctolagus cuniculus)
Explore G1SVB0 
Go to UniProtKB:  G1SVB0
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 60
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S8HB [auth CC]206Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TJW1 (Oryctolagus cuniculus)
Explore G1TJW1 
Go to UniProtKB:  G1TJW1
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 61
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S9 (Predicted)IB [auth DD]185Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPS9
Find proteins for B7NZS8 (Oryctolagus cuniculus)
Explore B7NZS8 
Go to UniProtKB:  B7NZS8
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 62
MoleculeChainsSequence LengthOrganismDetailsImage
eS10JB [auth SS]96Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TPV3 (Oryctolagus cuniculus)
Explore G1TPV3 
Go to UniProtKB:  G1TPV3
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 63
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S11KB [auth EE]151Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TRM4 (Oryctolagus cuniculus)
Explore G1TRM4 
Go to UniProtKB:  G1TRM4
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 64
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S12LB [auth RR]117Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SFR8 (Oryctolagus cuniculus)
Explore G1SFR8 
Go to UniProtKB:  G1SFR8
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 65
MoleculeChainsSequence LengthOrganismDetailsImage
ribosomal protein uS15MB [auth QQ]149Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPS13
Find proteins for G1SP51 (Oryctolagus cuniculus)
Explore G1SP51 
Go to UniProtKB:  G1SP51
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 66
MoleculeChainsSequence LengthOrganismDetailsImage
uS11NB [auth MM]135Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1T1F0 (Oryctolagus cuniculus)
Explore G1T1F0 
Go to UniProtKB:  G1T1F0
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 67
MoleculeChainsSequence LengthOrganismDetailsImage
uS17OB [auth WW]120Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPS15
Find proteins for G1U0Q2 (Oryctolagus cuniculus)
Explore G1U0Q2 
Go to UniProtKB:  G1U0Q2
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 68
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S16PB [auth UU]142Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SGX4 (Oryctolagus cuniculus)
Explore G1SGX4 
Go to UniProtKB:  G1SGX4
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 69
MoleculeChainsSequence LengthOrganismDetailsImage
eS17QB [auth KK]132Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TU13 (Oryctolagus cuniculus)
Explore G1TU13 
Go to UniProtKB:  G1TU13
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 70
MoleculeChainsSequence LengthOrganismDetailsImage
uS13RB [auth II]144Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TPG3 (Oryctolagus cuniculus)
Explore G1TPG3 
Go to UniProtKB:  G1TPG3
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 71
MoleculeChainsSequence LengthOrganismDetailsImage
eS19SB [auth PP]141Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TN62 (Oryctolagus cuniculus)
Explore G1TN62 
Go to UniProtKB:  G1TN62
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 72
MoleculeChainsSequence LengthOrganismDetailsImage
uS10TB [auth GG]100Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 73
MoleculeChainsSequence LengthOrganismDetailsImage
eS21UB [auth HH]83Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 74
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S15aVB [auth TT]129Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TG89 (Oryctolagus cuniculus)
Explore G1TG89 
Go to UniProtKB:  G1TG89
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 75
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S23WB [auth VV]141Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SZ47 (Oryctolagus cuniculus)
Explore G1SZ47 
Go to UniProtKB:  G1SZ47
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 76
MoleculeChainsSequence LengthOrganismDetailsImage
eS24XB [auth NN]124Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 77
MoleculeChainsSequence LengthOrganismDetailsImage
ribosomal protein eS25YB [auth OO]75Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TDB3 (Oryctolagus cuniculus)
Explore G1TDB3 
Go to UniProtKB:  G1TDB3
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 78
MoleculeChainsSequence LengthOrganismDetailsImage
eS26ZB [auth LL]101Oryctolagus cuniculusMutation(s): 0 
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 79
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S27AC [auth JJ]83Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1TZ76 (Oryctolagus cuniculus)
Explore G1TZ76 
Go to UniProtKB:  G1TZ76
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 80
MoleculeChainsSequence LengthOrganismDetailsImage
Ribosomal protein S28BC [auth FF]62Oryctolagus cuniculusMutation(s): 0 
Gene Names: RPS28
Find proteins for G1TIB4 (Oryctolagus cuniculus)
Explore G1TIB4 
Go to UniProtKB:  G1TIB4
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 81
MoleculeChainsSequence LengthOrganismDetailsImage
uS14CC [auth 9]55Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1U7M4 (Oryctolagus cuniculus)
Explore G1U7M4 
Go to UniProtKB:  G1U7M4
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 83
MoleculeChainsSequence LengthOrganismDetailsImage
eS31EC [auth 0]68Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SK22 (Oryctolagus cuniculus)
Explore G1SK22 
Go to UniProtKB:  G1SK22
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 84
MoleculeChainsSequence LengthOrganismDetailsImage
ribosomal protein RACK1FC [auth 6]313Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1SJB4 (Oryctolagus cuniculus)
Explore G1SJB4 
Go to UniProtKB:  G1SJB4
Protein Feature View
Expand
  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  Structure
Entity ID: 85
MoleculeChainsSequence LengthOrganismDetailsImage
40S ribosomal protein S30GC [auth AA]55Oryctolagus cuniculusMutation(s): 0 
Find proteins for G1T8A2 (Oryctolagus cuniculus)
Explore G1T8A2 
Go to UniProtKB:  G1T8A2
Protein Feature View
Expand
  • Reference Sequence
Find similar nucleic acids by:  (by identity cutoff)  |  Structure
Entity ID: 1
MoleculeChainsLengthOrganismImage
E-tRNAA [auth 3]75Saccharomyces cerevisiae
Find similar nucleic acids by:  (by identity cutoff)  |  Structure
Entity ID: 3
MoleculeChainsLengthOrganismImage
P-tRNAC [auth 2]76Saccharomyces cerevisiae
Find similar nucleic acids by:  (by identity cutoff)  |  Structure
Entity ID: 4
MoleculeChainsLengthOrganismImage
28S ribosomal RNAD [auth 5]3543Oryctolagus cuniculus
Find similar nucleic acids by:  (by identity cutoff)  |  Structure
Entity ID: 5
MoleculeChainsLengthOrganismImage
5S rRNAE [auth 7]120Oryctolagus cuniculus
Find similar nucleic acids by:  (by identity cutoff)  |  Structure
Entity ID: 6
MoleculeChainsLengthOrganismImage
5.8S ribosomal RNAF [auth 8]151Oryctolagus cuniculus
Find similar nucleic acids by:  (by identity cutoff)  |  Structure
Entity ID: 51
MoleculeChainsLengthOrganismImage
18S ribosomal RNAYA [auth K]1698Oryctolagus cuniculus
  • Find similar nucleic acids by:  Sequence   |   Structure
  • Entity ID: 82
    MoleculeChainsLengthOrganismImage
    mRNADC [auth 4]6Homo sapiens
    Small Molecules
    Ligands 2 Unique
    IDChainsName / Formula / InChI Key2D Diagram3D Interactions
    ZN
    Query on ZN

    Download Ideal Coordinates CCD File 
    RK [auth g], TK [auth j], VK [auth m], WK [auth o], XK [auth p], ZN [auth LL]ZINC ION
    Zn
    PTFCDOFLOPIGGS-UHFFFAOYSA-N
     Ligand Interaction
    MG
    Query on MG

    Download Ideal Coordinates CCD File 
    AD [auth 5] , AE [auth 5] , AF [auth 5] , AG [auth 5] , AH [auth 5] , AI [auth 5] , AJ [auth 5] , AK [auth 7] , 
    AD [auth 5],  AE [auth 5],  AF [auth 5],  AG [auth 5],  AH [auth 5],  AI [auth 5],  AJ [auth 5],  AK [auth 7],  AL [auth K],  AM [auth K],  AN [auth K],  BD [auth 5],  BE [auth 5],  BF [auth 5],  BG [auth 5],  BH [auth 5],  BI [auth 5],  BJ [auth 5],  BK [auth 7],  BL [auth K],  BM [auth K],  BN [auth K],  CD [auth 5],  CE [auth 5],  CF [auth 5],  CG [auth 5],  CH [auth 5],  CI [auth 5],  CJ [auth 5],  CK [auth 7],  CL [auth K],  CM [auth K],  CN [auth K],  DD [auth 5],  DE [auth 5],  DF [auth 5],  DG [auth 5],  DH [auth 5],  DI [auth 5],  DJ [auth 5],  DK [auth 7],  DL [auth K],  DM [auth K],  DN [auth K],  ED [auth 5],  EE [auth 5],  EF [auth 5],  EG [auth 5],  EH [auth 5],  EI [auth 5],  EJ [auth 5],  EK [auth 7],  EL [auth K],  EM [auth K],  EN [auth K],  FD [auth 5],  FE [auth 5],  FF [auth 5],  FG [auth 5],  FH [auth 5],  FI [auth 5],  FJ [auth 5],  FK [auth 7],  FL [auth K],  FM [auth K],  FN [auth K],  GD [auth 5],  GE [auth 5],  GF [auth 5],  GG [auth 5],  GH [auth 5],  GI [auth 5],  GJ [auth 5],  GK [auth 8],  GL [auth K],  GM [auth K],  GN [auth K],  HC [auth 5],  HD [auth 5],  HE [auth 5],  HF [auth 5],  HG [auth 5],  HH [auth 5],  HI [auth 5],  HJ [auth 5],  HK [auth 8],  HL [auth K],  HM [auth K],  HN [auth K],  IC [auth 5],  ID [auth 5],  IE [auth 5],  IF [auth 5],  IG [auth 5],  IH [auth 5],  II [auth 5],  IJ [auth 5],  IK [auth 8],  IL [auth K],  IM [auth K],  IN [auth K],  JC [auth 5],  JD [auth 5],  JE [auth 5],  JF [auth 5],  JG [auth 5],  JH [auth 5],  JI [auth 5],  JJ [auth 5],  JK [auth 8],  JL [auth K],  JM [auth K],  JN [auth K],  KC [auth 5],  KD [auth 5],  KE [auth 5],  KF [auth 5],  KG [auth 5],  KH [auth 5],  KI [auth 5],  KJ [auth 5],  KK [auth 8],  KL [auth K],  KM [auth K],  KN [auth K],  LC [auth 5],  LD [auth 5],  LE [auth 5],  LF [auth 5],  LG [auth 5],  LH [auth 5],  LI [auth 5],  LJ [auth 5],  LK [auth I],  LL [auth K],  LM [auth K],  LN [auth K],  MC [auth 5],  MD [auth 5],  ME [auth 5],  MF [auth 5],  MG [auth 5],  MH [auth 5],  MI [auth 5],  MJ [auth 5],  MK [auth P],  ML [auth K],  MM [auth K],  MN [auth K],  NC [auth 5],  ND [auth 5],  NE [auth 5],  NF [auth 5],  NG [auth 5],  NH [auth 5],  NI [auth 5],  NJ [auth 5],  NK [auth P],  NL [auth K],  NM [auth K],  NN [auth K],  OC [auth 5],  OD [auth 5],  OE [auth 5],  OF [auth 5],  OG [auth 5],  OH [auth 5],  OI [auth 5],  OJ [auth 5],  OK [auth V],  OL [auth K],  OM [auth K],  ON [auth K],  PC [auth 5],  PD [auth 5],  PE [auth 5],  PF [auth 5],  PG [auth 5],  PH [auth 5],  PI [auth 5],  PJ [auth 5],  PK [auth a],  PL [auth K],  PM [auth K],  PN [auth K],  QC [auth 5],  QD [auth 5],  QE [auth 5],  QF [auth 5],  QG [auth 5],  QH [auth 5],  QI [auth 5],  QJ [auth 5],  QK [auth e],  QL [auth K],  QM [auth K],  QN [auth K],  RC [auth 5],  RD [auth 5],  RE [auth 5],  RF [auth 5],  RG [auth 5],  RH [auth 5],  RI [auth 5],  RJ [auth 5],  RL [auth K],  RM [auth K],  RN [auth K],  SC [auth 5],  SD [auth 5],  SE [auth 5],  SF [auth 5],  SG [auth 5],  SH [auth 5],  SI [auth 5],  SJ [auth 5],  SK [auth g],  SL [auth K],  SM [auth K],  SN [auth K],  TC [auth 5],  TD [auth 5],  TE [auth 5],  TF [auth 5],  TG [auth 5],  TH [auth 5],  TI [auth 5],  TJ [auth 5],  TL [auth K],  TM [auth K],  TN [auth K],  UC [auth 5],  UD [auth 5],  UE [auth 5],  UF [auth 5],  UG [auth 5],  UH [auth 5],  UI [auth 5],  UJ [auth 5],  UK [auth j],  UL [auth K],  UM [auth K],  UN [auth K],  VC [auth 5],  VD [auth 5],  VE [auth 5],  VF [auth 5],  VG [auth 5],  VH [auth 5],  VI [auth 5],  VJ [auth 5],  VL [auth K],  VM [auth K],  VN [auth K],  WC [auth 5],  WD [auth 5],  WE [auth 5],  WF [auth 5],  WG [auth 5],  WH [auth 5],  WI [auth 5],  WJ [auth 5],  WL [auth K],  WM [auth K],  WN [auth K],  XC [auth 5],  XD [auth 5],  XE [auth 5],  XF [auth 5],  XG [auth 5],  XH [auth 5],  XI [auth 5],  XJ [auth 5],  XL [auth K],  XM [auth K],  XN [auth K],  YC [auth 5],  YD [auth 5],  YE [auth 5],  YF [auth 5],  YG [auth 5],  YH [auth 5],  YI [auth 5],  YJ [auth 5],  YK [auth K],  YL [auth K],  YM [auth K],  YN [auth PP],  ZC [auth 5],  ZD [auth 5],  ZE [auth 5],  ZF [auth 5],  ZG [auth 5],  ZH [auth 5],  ZI [auth 5],  ZJ [auth 5],  ZK [auth K],  ZL [auth K],  ZM [auth K]
    MAGNESIUM ION
    Mg
    JLVVSXFLKOJNIY-UHFFFAOYSA-N
     Ligand Interaction
    Experimental Data & Validation

    Experimental Data

    • Method: ELECTRON MICROSCOPY
    • Resolution: 3.00 Å
    • Aggregation State: PARTICLE 
    • Reconstruction Method: SINGLE PARTICLE 

    Structure Validation

    View Full Validation Report



    Entry History & Funding Information

    Deposition Data


    Funding OrganizationLocationGrant Number
    German Research FoundationGermanyGRK1721

    Revision History  (Full details and data files)

    • Version 1.0: 2019-07-10
      Type: Initial release
    • Version 1.1: 2019-10-30
      Changes: Advisory, Data collection, Derived calculations