Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Lockbaum, G.J., Henes, M., Lee, J.M., Timm, J., Nalivaika, E.A., Thompson, P.R., Kurt Yilmaz, N., Schiffer, C.A.(2021) Biochemistry 60: 2925-2931
- PubMed: 34506130 
- DOI: 10.1021/acs.biochem.1c00414
- Primary Citation of Related Structures:  
7L8H, 7L8I, 7L8J - PubMed Abstract: 
Rupintrivir targets the 3C cysteine proteases of the picornaviridae family, which includes rhinoviruses and enteroviruses that cause a range of human diseases. Despite being a pan-3C protease inhibitor, rupintrivir activity is extremely weak against the homologous 3C-like protease of SARS-CoV-2 ...