7LXT

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib


Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 3.40 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 1.0 of the entry. See complete history


Literature

Proteasome endopeptidase complex

Xie, S.C.Tilley, L.

To be published.

Macromolecules
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Entity ID: 1
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome alpha-1 subunitA, O260Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0807500
EC: 3.4.25.1
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Find proteins for Q8IAR3 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 2
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome alpha-2 subunitB, P235Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0608500
EC: 3.4.25.1
UniProt
Find proteins for C6KST3 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 3
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome alpha-3 subunitC, Q246Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_1353800
EC: 3.4.25.1
UniProt
Find proteins for Q8IDG3 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 4
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome alpha-4 subunitD, R241Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_1353900
EC: 3.4.25.1
UniProt
Find proteins for Q8IDG2 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 5
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome alpha-5 subunitE, S256Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0727400
EC: 3.4.25.1
UniProt
Find proteins for Q8IBI3 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 6
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome alpha-6 subunitF, T254Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_1474800
EC: 3.4.25.1
UniProt
Find proteins for Q8IK90 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 7
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome alpha-7 subunitG, U252Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0317000
EC: 3.4.25.1
UniProt
Find proteins for O77396 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 8
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome beta-1 subunitH, V252Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0931800
EC: 3.4.25.1
UniProt
Find proteins for Q8I0U7 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 9
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome beta-2 subunitI, W229Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_1328100
EC: 3.4.25.1
UniProt
Find proteins for Q8I6T3 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 10
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome beta-3 subunitJ, X218Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0108000
EC: 3.4.25.1
UniProt
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Entity ID: 11
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome beta-4 subunitK, Y195Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_1470900
EC: 3.4.25.1
UniProt
Find proteins for Q8IKC9 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 12
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome beta-5 subunitL, Z211Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_1011400
EC: 3.4.25.1
UniProt
Find proteins for Q8IJT1 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 13
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome beta-6 subunitM, AA [auth a]240Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0518300
EC: 3.4.25.1
UniProt
Find proteins for A0A5K1K7U1 (Plasmodium falciparum (isolate 3D7))
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Entity ID: 14
MoleculeChainsSequence LengthOrganismDetailsImage
20S proteasome beta-7 subunitN, BA [auth b]265Plasmodium falciparum 3D7Mutation(s): 0 
Gene Names: PF3D7_0803800
EC: 3.4.25.1
UniProt
Find proteins for Q7K6A9 (Plasmodium falciparum (isolate 3D7))
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Small Molecules
Ligands 1 Unique
IDChainsName / Formula / InChI Key2D Diagram3D Interactions
BO2 (Subject of Investigation/LOI)
Query on BO2

Download Ideal Coordinates CCD File 
CA [auth H], DA [auth I], EA [auth L], FA [auth V], GA [auth W], HA [auth Z]N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
C19 H25 B N4 O4
GXJABQQUPOEUTA-RDJZCZTQSA-N
 Ligand Interaction
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 3.40 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

Structure Validation

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Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
Global Health Innovative Technology FundUnited StatesRFP-HTLP-H2019-101
Australian Research Council (ARC)AustraliaFL150100106

Revision History  (Full details and data files)

  • Version 1.0: 2021-09-22
    Type: Initial release