Molecular basis for differential activation of p101 and p84 complexes of PI3K gamma by Ras and GPCRs.
Rathinaswamy, M.K., Jenkins, M.L., Duewell, B.R., Zhang, X., Harris, N.J., Evans, J.T., Stariha, J.T.B., Dalwadi, U., Fleming, K.D., Ranga-Prasad, H., Yip, C.K., Williams, R.L., Hansen, S.D., Burke, J.E.(2023) Cell Rep 42: 112172-112172
- PubMed: 36842083 
- DOI: https://doi.org/10.1016/j.celrep.2023.112172
- Primary Citation of Related Structures:  
8AJ8 - PubMed Abstract: 
Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein-coupled receptors (GPCRs) and Ras. Using a combination of X-ray crystallography, hydrogen deuterium exchange mass spectrometry (HDX-MS), electron microscopy, molecular modeling, single-molecule imaging, and activity assays, we identify molecular differences between p110γ-p84 and p110γ-p101 that explain their differential membrane recruitment and activation by Ras and GPCRs ...